The invention relates to the field of odor removal, in particular to a preparing method of an odor removal bead with a core-shell structure and the function of absorbing water. The core-shell structure is involved and comprises an outer layer and an inner core covered with the outer layer, and the bead is mainly prepared by steps of preparation of a clathrate compound, preparation of the inner core, preparation of the outer layer and drying granulation. The material which forms a micropore structure when swelling in the presence of water restores the original shape when losing water, the innercore is slow-release particles formed by the clathrate compound containing camphor essential oil, eucalyptus essential oil or yucca schidigera plant essential oil and other natural odor removal materials, high-molecular water-absorbing capsule walls of the outer layer swell in the presence of water, then micropores in the high-molecular capsule walls are opened, thus water enters the micropores and is in contact with the inner core, the inner core releases odor removal substances in the presence of water, and then the odor removal substances are slowly released through the micropores; when the adsorbed water molecules reach the saturation value, along with water loss, the odor removal bead is gradually shrunk day by day until the bead restores the original size, after water is re-added into the bead, the original odor removal function can be restored, the bead can be repeatedly used multiple times, and the safe, long-acting and lasting odor removal effects are achieved.