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Preparation and Application of Drug Sustained and Controlled Release System with Liquid Silicone Rubber as Carrier

A liquid silicone rubber, silicone rubber technology, used in drug combination, drug delivery, endocrine system diseases, etc.

Active Publication Date: 2019-03-05
国家卫生健康委科学技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no patent on the sustained and controlled release system of non-steroidal anti-inflammatory drugs, imidazole antifungal drugs, purine nucleoside antiviral drugs, steroidal progestins and estrogen drugs using liquid silicone rubber as a carrier. Appear

Method used

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  • Preparation and Application of Drug Sustained and Controlled Release System with Liquid Silicone Rubber as Carrier
  • Preparation and Application of Drug Sustained and Controlled Release System with Liquid Silicone Rubber as Carrier
  • Preparation and Application of Drug Sustained and Controlled Release System with Liquid Silicone Rubber as Carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 100g of liquid silicone rubber MED-6382 matrix, 0.5g of cross-linking agent, stir for 30s to mix, weigh 2g of Gestodene, add it to the silicone rubber mixture and stir for 30s to fully mix the drug and silicone rubber mixture, use 50ml Transfer the appropriate amount of the mixture to the ring mold with the syringe, avoid air bubbles as much as possible during the operation, then place the mold at 80°C for 20 minutes, and remove the formed ring silicone rubber product from the mold. The outer diameter of the silicone rubber product is is 50mm, and the cross-sectional diameter is 4mm. Mix the two components of C6-165 medical silicone rubber at a ratio of 1:1 for 10 minutes to prepare a film with a thickness of 0.75mm, and wrap the film on a ring composed of 1 / 4 drug-containing skeleton and 1 / 4 blank skeleton On the surface, vulcanize at 130°C for 10 minutes to obtain a block-type reservoir-type silicone rubber rod-shaped drug release carrier, and use the slurry meth...

Embodiment 2

[0027] Take 100g of liquid silicone rubber MED-6382 matrix, 0.5g of cross-linking agent, stir for 30s to make it evenly mixed, weigh 15g of levonorgestrel and add it to the silicone rubber mixture and stir for 30s to fully mix the drug and the silicone rubber mixture, use Transfer an appropriate amount of the mixture into a rod-shaped mold with a 50ml syringe, avoid air bubbles as much as possible during the operation, then place the mold at 80°C for 20 minutes, and remove the formed rod-shaped silicone rubber product from the mold. The length of the silicone rubber product is 6.5 cm, the cross-sectional diameter is 6.5mm. Mix the two components of C6-165 medical silicone rubber according to the ratio of 1:1 for 10 minutes to prepare a film with a thickness of 0.75mm, wrap the film on the surface of the molded silicone rubber product, and vulcanize at 130°C for 10 minutes to obtain the storage type silicone rubber For the rod-shaped drug release carrier, the sample is subjecte...

Embodiment 3

[0029] Take 100g of liquid silicone rubber MED-6382 matrix, 0.5g of cross-linking agent, stir for 30s to mix, weigh 15g of acyclovir, add it to the silicone rubber mixture and stir for 30s to fully mix the drug and silicone rubber mixture, use 50ml Transfer the appropriate amount of the mixture to the rod-shaped mold with the syringe, avoid air bubbles as much as possible during the operation, then place the mold at 80°C for 20 minutes, and remove the formed rod-shaped silicone rubber product from the mold. The length of the silicone rubber product is 6.5cm , the cross-sectional diameter is 6.5mm. Mix the two components of Q7-4765 medical silicone rubber according to the ratio of 1:1 for 10 minutes to prepare a film with a thickness of 0.75mm, wrap the film on the surface of the molded silicone rubber product, and vulcanize at 130°C for 10 minutes to obtain the storage type silicone rubber For the rod-shaped drug release carrier, the sample is subjected to an in vitro release ...

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Abstract

The invention relates to preparation and application of a drug slow-release and controlled-release system with liquid silicone rubber as a carrier. The slow-release and controlled-release system consists of a controlled-released film and one or more framework sections, wherein at least one framework section contains drugs; one or more additives are contained in the framework and the film, and are used for adjusting the release speed of the drugs; the framework is prepared through injection moulding; the controlled-released film is added through injection moulding, hot-pressing vulcanization or high-temperature vulcanization; the drug contained in the slow-release and controlled-release system can be anti-inflammatory and analgesic non-steroidal anti-inflammatory drugs, imidazoles antifungal drugs and purine nucleoside antiviral drugs which are applied to a genital tract, and also can be steroidal progesterone and estrogen drugs applied to contraception, hormone replacement therapy and gynaecological disease treatment. The slow-release and controlled-release system can be used for preparing a vaginal ring or an IUD and an assembly thereof, and can release the contained drugs at a slow or constant speed.

Description

Technical field: [0001] The invention belongs to the field of medical polymer material sustained-release system and its preparation, and particularly relates to the system having various application fields. Background technique: [0002] With the continuous expansion of the world's population, it is imminent to actively adopt safe and effective contraceptive measures to control the population, improve the quality of the population and the health level of the whole people; and the accelerated pace of life and increasingly fierce competition make people's pressure Increasingly, especially professional women, gynecological diseases follow one after another, such as uterine fibroids, endometriosis, vaginitis, etc.; in 2011, 34 million people in the world were troubled by HIV / AIDS, and 2.5 million newly infected people have already 1.7 million people died; as of the end of 2011, there were about 780,000 PLHIV survivors in China, and women accounted for 28.6%. It can be seen that...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/34A61P29/00A61P31/10A61P31/12A61P5/30A61P5/36A61P15/00A61P31/02A61P15/18
Inventor 宁美英李春晓段雪艳张莹刘颖
Owner 国家卫生健康委科学技术研究所
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