Compound, composition, and method for protecting skin from high energy visible light

A composition and compound technology, applied in the directions of skin care preparations, drug combinations, skin diseases, etc.

Inactive Publication Date: 2013-04-03
LIPO CHEM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the color of such products is not acceptable to consumers

Method used

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  • Compound, composition, and method for protecting skin from high energy visible light
  • Compound, composition, and method for protecting skin from high energy visible light
  • Compound, composition, and method for protecting skin from high energy visible light

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] a) Synthesis:

[0046] Melanin was synthesized as follows: 15g L-tyrosine was dissolved in 800mL water; 60g ammonium persulfate was dissolved in 200mL water; 26g sodium hydroxide (NaOH) was dissolved in 50mL water. The pH was adjusted to 8.5 with sodium hydroxide, and the solution was stirred for 10 hours.

[0047] b) Purification:

[0048] Under stirring, the product was acidified with hydrochloric acid (HCl) to pH 1.5 using about 1 L of water. Continue stirring for about 10 minutes, remove the stirrer, and let the product stand for 24 hours. The supernatant was separated, about 1 L of deionized water was added and the pH was adjusted to 2 with dilute hydrochloric acid, while stirring for 10 minutes; the product was allowed to stand for 24 hours without stirring.

[0049] c) Fractionation:

[0050] Raise the pH to between 3-4 with sodium hydroxide while stirring for about 1 hour, stop stirring and let the product stand for 24 hours. Separate the supernatant or collect the su...

example ）

[0079] Additional UV filters (including combinations of any two or more of the following) are selected from the following categories (with specific examples): p-aminobenzoic acid, its salts and derivatives (ethyl ester, isobutyl ester) , Glyceryl ester; p-dimethylaminobenzoic acid); anthranilic acid (anthranilic acid esters; methyl ester, menthyl ester, phenyl ester, benzyl ester, phenethyl ester, agarwood Esters, terpinenyl esters and cyclohexenyl esters); salicylate esters (octyl ester, pentyl ester, phenyl ester, benzyl ester, menthyl ester (homosalate), glyceryl ester and Dipropanol ester); cinnamic acid derivatives (menthyl ester and benzyl ester, α-phenylcinnamonitrile; butyl cinnamoyl pyruvate); dihydroxycinnamic acid derivative (umbrella Ketone, methyl umbelliferone, methyl acetyl umbelliferone); camphor derivatives (3-benzylidene, 4-methylbenzylidene, polyacrylamidomethyl benzylidene ), benzalkonium methosulfate (benzalkonium methosulfate), benzalkonium camphor sulfon...

Embodiment 2

[0127] Example 2: Emulsion preparation

[0128]

[0129] 1） The order of premixing and adding the ingredients of the composition.

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Abstract

A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.

Description

[0001] Cross reference of related applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 61 / 313,456 filed on March 12, 2010, and is incorporated herein by reference in its entirety. Technical field [0003] This application relates to the protection of the skin from the harmful effects of high energy visible (HEV) light. More particularly, the present invention relates to a melanin derivative, which reduces the risk of skin photoaging caused by HEV light, overcomes the delay in the repair of skin damage caused by sunlight and delays the photodamage and photoaging of the skin. The melanin derivatives can be formulated into various topical skin care compositions, including sunscreen compositions. Background technique [0004] The skin care industry has long recognized that sun exposure increases the risk of wrinkles, age spots, and sagging skin. Such skin damage is photochemical in nature and is related to high-energy, short-wavelength l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/542A61K31/404A61K8/49A61K8/97A61P17/00A61Q17/04
CPCA61Q19/00C08G75/00C08G73/0672A61K8/35A61K8/72A61K8/84A61Q1/02A61K8/37A61Q17/04A61K8/40A61P17/00
Inventor N.达彦J.M.加拉斯
Owner LIPO CHEM
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