Method to inhibit cell growth using oligonucleotides

a technology of oligonucleotides and oligonucleotide, which is applied in the directions of aerosol delivery, extracellular fluid disorder, peptide/protein ingredients, etc., can solve the problems of morbidity and mortality rates that have not significantly improved, and achieve the effects of reducing the occurrence of skin cancer, preventing spongiosis, blistering or dyskeratosis
US20060052323A1Inactive Publication Date: 2006-03-09TRUSTEES OF BOSTON UNIV
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
TRUSTEES OF BOSTON UNIV
Publication Date
2006-03-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation-in-part of application Ser. No. 10 / 122,630 filed Apr. 12, 2002, which is a continuation-in-part of International Application No. PCT / US01 / 10162, which designated the United States and was filed on Mar. 30, 2001, published in English, which is a continuation-in-part of application Ser. No. 09 / 540,843 filed Mar. 31, 2000, which is a continuation-in-part of application Ser. No. 09 / 048,927 filed Mar. 26, 1998, now U.S. Pat. No. 6,147,056, which is a continuation-in-part of the U.S. National stage of International Application No. PCT / US96 / 08386 filed Jun. 3, 1996, published in English, U.S. application Ser. No. 08 / 952,697, now abandoned, which is a continuation-in-part of application Ser. No. 08 / 467,012 filed Jun. 6, 1995, now U.S. Pat. No. 5,955,059. The entire teachings of the above applications and issued patents are incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] Mammalian cells have a complex response...

Claims

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