74 results about "Layers skin" patented technology

The invention belongs to the technical field of tissue engineering, and particularly discloses a preparation method of a 3D full-thickness skin model. The preparation method provided by the invention comprises the following steps: constructing a corium layer, constructing an inner epidermal layer through first epidermal inoculation, constructing an epidermal layer through second epidermal inoculation and obtaining a complete 3D full-thickness skin model through co-culture. The 3D full-thickness skin model obtained through the preparation method is distinct in gradation, uniform in thickness, free of shrinkage and stable in quality, the epidermal layer and the corium layer are uniformly fused, and the 3D full-thickness skin model is suitable for skin function research and sample evaluation. Meanwhile, the preparation method provided by the invention is simple in process and convenient to operate, does not need additional reagents or anti-shrinkage tools, can meet the requirements of large-scale industrial production, and has good production feasibility and market application prospects.

The invention relates to a double-layer dressing for promoting wound healing and inhibiting scars and a preparation method and application thereof.The double-layer dressing comprises a hydrogel layer and a piezoelectric film layer compounded on the hydrogel layer, and the piezoelectric film layer is prepared by mixing an organic piezoelectric material, a ferroelectric material and an organic solvent and then conducting an electrostatic spinning technology; the hydrogel layer is formed by curing a methacrylic anhydride acellular extracellular matrix, methacrylic anhydride catechol chitosan and conductive nanoparticles under the action of a curing agent. The lower skin contact layer of the double-layer dressing is the hydrogel layer, so that the directional growth of fibroblasts is favorably induced; the upper dressing is a piezoelectric material composite ferroelectric material, is beneficial to piezoelectric stimulation re-induction function recovery after final skin repair and guidance of directional growth of wound cells, and has good skin wound induction repair and scar inhibition effects.

The invention relates to the technical field of puncture needle training, and particularly discloses a medical simulation puncture needle training device which comprises a simulation arm, a simulation puncture part is arranged on the end face of the simulation arm, a simulation part is fixed in the simulation puncture part, and a simulation cavity is formed in the simulation part; the simulation device further comprises a simulation skin simulation assembly and a driving assembly, the simulation skin simulation assembly is arranged in the simulation cavity, the driving assembly is arranged on the side edge of the simulation skin simulation assembly, the simulation skin simulation assembly comprises a first skin layer arranged in the simulation cavity, and a second skin layer is arranged at the bottom of the first skin layer. The driving assembly works to adjust the tension of the first skin layer and the second skin layer, and the skin states of patients of various ages are simulated; adjusting operation of the elasticity degree of the second skin layer, the wrinkle degree of the first skin layer and the bending degree of the simulated blood vessel is achieved, a trainer can experience real touch of skins of different age groups on the same model, and intensified training is carried out in a targeted mode.

The invention discloses a scar-removing microneedle body and a scar-removing microneedle composite patch, and belongs to the technical field of microneedle patches, the scar-removing microneedle composite patch comprises a patch layer and a microneedle layer, the patch layer comprises a silica gel layer and a substrate layer, and the substrate layer is arranged between the microneedle layer and the silica gel layer; the microneedle layer comprises a plurality of microneedle bodies, each microneedle body comprises an epidermal segment and a dermis segment, and the epidermal segment is composed of a matrix and a first scar removing component; the dermis segment is composed of a matrix and a second scar removing component; the scar-removing microneedle body is of a two-section structural design, two scar-removing components are combined, different scar-removing components of epidermal layer targeting and corium layer targeting are accurately provided to a target skin layer, individual scar-removing components can be concentrated on the target skin layer, and the scar-removing effect is improved. Meanwhile, side effects or interference possibly generated by scar removing components on different skin layers can be avoided, and the precise and efficient compound scar removing effect is achieved.

The invention provides a skin fibrosis in-vitro model as well as a construction method and application thereof, and relates to the technical field of cell biology. According to the skin fibrosis in-vitro model construction method, a full-thickness skin model with an epidermal layer and a corium layer is constructed by utilizing a cell culture chamber or a cell culture micro-fluidic chip, and the skin fibrosis in-vitro model is obtained by performing induced culture through a chemical reagent, a growth factor or mechanical stress while the corium layer is constructed. According to the construction method, the problem that an existing in-vitro model can only reflect early-stage fibrosis skin characteristics and cannot effectively simulate fibrosis skin formed under the condition of a long disease course is solved. Besides, the corium layer and the epidermal layer in the full-thickness skin structure are not separated, isolated and differentiated through a porous membrane, corium layer fibrosis can generate more direct influence on the epidermis, richer inflammatory factor expression change of the whole model is obvious, and the simulation degree of skin fibrosis diseases is higher.

The invention discloses a fingertip-imitating multi-stage flexible sensor which can accurately measure the surface curvature, shape, hardness and multi-dimensional force of an object to be measured through a skin-imitating layer, a muscle-imitating layer and a skeleton-imitating layer from outside to inside and a simple structure.

The invention relates to the technical field of functional nutritious food, in particular to multi-layer skin nutrition powder with a whole-spectrum skin growth and repair promoting effect and a preparation method and application thereof, the core of the multi-layer skin nutrition powder is composed of a collagen peptide system (60-62%), a proteoglycan system (20-22%) and the like, collagen peptide is compounded with three sources of cattle, fish and chicken, and the multi-layer skin nutrition powder has the advantages that the multi-layer skin nutrition powder is prepared; according to the present invention, with the combination of the following components, the skin structure and activity are jointly promoted by using the synergistic effect of the functional polypeptide compound (2.5-3.5%) and the plant active component (3.5-4.5%) rich in asiaticoside and procyanidine, and the nutrition enhancers (4-5%) such as L-ascorbic acid and amino acid chelated zinc and the food-grade auxiliary materials (8-10%) such as microcrystalline cellulose are integrated in the formula, such that the various systems achieve the synergistic effect so as to achieve the effect of nourishing the skin; through the synergistic compatibility of the three-source collagen peptide, the comprehensive supplement of various types of collagen in skin tissues is realized.

The invention relates to a composition for skin care. In particular, the present invention relates to a skin care composition comprising a myrrh resin extract and a retinoid. The invention also relates to a method for treating the skin using said composition and to a method for enhancing the anti-aging effect of retinoids in the skin layer.

The utility model relates to an abdominal cavity sealing dressing capable of displaying temperature and humidity. The abdominal cavity sealing dressing comprises a polyurethane layer, a humidity sensor, a hardened layer, a pressure sensor, a temperature sensor and a hemostasis layer, the humidity sensor is arranged on the side, attached to the skin, of the polyurethane layer. The abdominal cavity sealing dressing capable of displaying the temperature and the humidity is of a multi-layer composite structure, the dressing is provided with a signal module and used for wireless transmission of temperature and pressure data and monitoring of the internal condition of the abdominal cavity, the device is structurally similar to human normal skin, and the innermost chitosan hemostasis layer is similar to a subcutaneous tissue layer; the effect of protecting internal tissues and organs is achieved; the middle layer comprises a sensor which can reflect partial key indexes of the abdominal cavity and is similar to a neuroreceptor part; the outer layer is good in mechanical performance, can resist external mechanical injuries and is similar to a skin layer, the effect similar to the skin can be achieved through the bionic structure, and treatment of the open abdominal wall trauma is more efficient and intelligent.

The utility model belongs to the technical field of multi-layer egg roll production, and particularly relates to a multi-layer egg roll production line which comprises a multi-layer wrapper forming machine, a multi-layer wrapper splitting machine is arranged on the right side of the multi-layer wrapper forming machine, and a double-layer conveyor is arranged on the right side of the multi-layer wrapper splitting machine. According to the scheme, through the arrangement of the multi-layer skin forming machine, egg skin primary pulp can be quickly processed into multi-layer skins, the multi-layer skins can be cut into lengths according to requirements under the action of the multi-layer skin cutting machine, all sections of the multi-layer skins can be pulled apart by a certain distance under the action of the double-layer conveyor, and the multi-layer skins can be cut into different lengths under the action of the plane smearing machine. Cream can be evenly smeared on each section of multi-layer skin, under the action of the tracking smearing machine, the front end of each section of multi-layer skin can be smeared with a piece of transverse cream so as to prevent hollowness during rolling, finally under the action of the multi-layer roll forming machine, the front end of each section of multi-layer skin can be rolled up by a roll head, each section of multi-layer skin is subjected to rolling forming, and a finished product is output. And the production efficiency is improved.

The present invention provides an emulsified composition, a preparation method, and an application thereof. The emulsified composition comprises a polyol, a sucrose fatty acid ester, and a polyglycerol fatty acid ester; the sucrose fatty acid ester is a combination of sucrose laurate, sucrose dilaurate, sucrose palmitate, and sucrose stearate. The emulsified composition of the present invention has a smaller emulsified particle size than conventional emulsions after use in cosmetics, and a narrower particle size distribution range, creating a better skin feel and having higher kinetic stability. The smaller particle size helps effectively deliver active ingredients into the skin, making it a potential carrier for cosmetic ingredients, achieving optimal dispersion of active ingredients in specific skin layers, resulting in better efficacy. Furthermore, the smaller particle size allows for rapid penetration into the deep layers of the skin and pores, effectively rinsing away makeup and dirt.

The present invention relates to the technical field of multi-layer skin covering, and discloses a fiber prepreg multi-layer skin covering equipment and a covering process. The covering equipment includes a first support frame and a second support frame, the first support frame and the second support frame having two, and a support frame arranged on one side of the first support frame and the second support frame, one side of the support frame arranged on the side of the first support frame is provided with a base frame, a winding roller is rotatably connected in the base frame, and a hot pressing roller is lifted and lowered on the support frame, and also includes: a cutting part, which is arranged above the winding roller; a clamping part, which is lifted and lowered on one side of the cutting part to clamp and move the cut skin; a gluing part, which is arranged on one side of the clamping part to adhere the cut skin to the new winding roller; the present invention triggers the action of clamping and arranging the cut skin and the action of arranging the adhesive by using the cutting action of the ultrasonic knife, and at the same time supports and moves the cut skin to be adhered to the replaced winding roller, thereby improving work efficiency.

The invention relates to imitation body equipment, a testing system and a testing method, and the imitation body equipment comprises an imitation skin layer; the signal simulation layer is embedded in the bionic skin layer; and the control assembly is connected with the signal simulation layer and used for driving the transmissivity of the signal simulation layer to change based on a reference physiological signal so as to simulate the reference physiological signal.

The invention relates to the technical field of microneedle transdermal drug delivery, in particular to a puncture depth self-adaptive microneedle system. The microneedle system comprises a microneedle array used for puncturing skin, providing a sampling point for detecting skin impedance at a skin layer touched by a needle tip of the microneedle array, and releasing drugs; the detection unit is connected with the microneedle array and is configured to acquire skin impedance at the sampling point in a short pulse mode and output a control signal when it is judged that the needle tip of the microneedle array penetrates through the cuticle according to the skin impedance; the execution unit is respectively connected with the microneedle array and the detection unit and is configured to receive a control signal from the detection unit to stop the microneedle array from continuously puncturing into the skin after the detection unit judges the penetration, so that the penetration depth of the microneedle can be actively limited based on the electrical characteristic change of the skin in the penetration process of the microneedle; the problem of skin individual difference is effectively solved, and the active recognition capability and the automatic adjustment capability of the real-time penetration state are achieved.

The invention provides a method for preparing a skin graft composition comprising (a) obtaining, from a subject requiring a skin layer patch or dressing, a skin sample, (b) placing the skin sample in a container with a sterile medium, (c) separating fibroblasts and keratinocytes from the skin sample to obtain a solution comprising fibroblasts and keratinocytes or reshaping and resizing the skin sample to obtain a solution comprising the reshaped and resized skin sample, and (d) combining the fibroblasts and the keratinocytes with a matrix to thereby form a skin graft composition. The invention also provides a method for providing a skin graft composition to a subject, as well as a method of providing a skin layer patch or dressing, or a skin graft, to a subject in need thereof.

The application relates to a recombinant type I collagen and application thereof, which utilizes the characteristics of Pichia pastoris capable of secreting and expressing recombinant proteins, secretes the recombinant type I collagen on the culture medium supernatant, and reduces the difficulty of protein purification. In addition, the integrin site RGD is inserted into the collagen to form a recombinant type I collagen with high stability and high expression. According to the relative proliferation of cells and the relative adhesion experiment of cells, it can be seen that the recombinant type I collagen has the effects of promoting the proliferation of skin fibroblasts, improving the skin, promoting wound healing, promoting the adhesion of fibroblasts in the skin layer and the like. Therefore, the recombinant type I collagen has great potential applications in the fields of skin care and beauty, medical treatment and the like.

A hydration level tracking system and method measures microwave energy accepted by skin in a desired target area of a user or patient in order to determine, in real time and in vivo, representative hydration levels. A measurement unit comprises a transmitter operatively connected to an antenna to deliver energy towards appropriate layer. The measurement unit determines an accepted energy power value of the skin associated with the desired target area. This measurement energy power value is compared with a calibration value, and the difference is used to determine a representative hydration level value. The determined hydration value may further be acclimatized using additional sensed values compensating for biological and ambient factors relevant to the patient. The final determined hydration level value can be displayed for reading and / or transmitted and stored for recording for further reference.

The present invention relates to the technical field of puncture needle training, and specifically discloses a medical simulation puncture needle training device, including: a simulation arm, a simulation puncture member is provided on the end face of the simulation arm, and a simulation member is fixed inside the simulation puncture member, and a simulation cavity is opened inside the simulation member; further including: a simulation skin simulation component and a driving component, the simulation skin simulation component is arranged inside the simulation cavity, the driving component is arranged on the side of the simulation skin simulation component, the simulation skin simulation component includes a skin layer one arranged inside the simulation cavity, and a skin layer two is arranged at the bottom of the skin layer one, and the driving component works to adjust the tension between the skin layer one and the skin layer two to simulate the skin states of patients of various ages; realizing the adjustment operations of the elasticity degree of the skin layer two, the wrinkling degree of the skin layer one, and the bending degree of the simulated blood vessels, so that the trainer can experience the real touch of the skin of different ages on the same model and conduct targeted intensive training.

The disclosure relates to a simulated tissue useful as a surgical training aid, the simulated tissue including at least the following: (a) a skin layer, (b) a fat layer, (c) a muscle layer, (d) a first mesh, (e) an interstitial layer, (f) a second mesh, (g) a structural layer incorporating one or more anatomical components, and (h) a base layer. Methods for constructing the simulated tissue are also disclosed. The simulated tissues described herein can be used as a soft tissue surgical task trainer for numerous surgical procedures.

The invention discloses a wearable anti-hair-loss hair growth monitoring device and system based on low-power ultrasound, and relates to the technical field of hair growth monitoring and treatment. Comprising an individual structure sensing and modeling module used for collecting ultrasonic monitoring data in real time and carrying out data preprocessing; evaluating the thickness of a fat layer and the thickness of a skin layer, and constructing a curvature estimation model; the sound field simulation and sound intensity prediction module is used for judging the local ultrasonic sound intensity of the hair follicle layer, performing graded ultrasonic regulation and control and calculating a sound intensity correction factor; the individualized self-adaptive regulation and control module is used for updating sound wave transmitting power, collecting temperature data in real time and evaluating local temperature rise safety; and the monitoring feedback and system self-learning module is used for carrying out scalp state analysis feedback and realizing algorithm and threshold optimization. The problem that safe and effective transmitting power cannot be uniformly preset due to the fact that the sound intensity of the same ultrasonic power in a hair follicle layer is too high or insufficient due to the fact that the scalp thickness, fat layer and bone surface curvature difference of different users is large is solved.

The present disclosure relates to a composition for improving or increasing skin radiance or transparency, containing compound K. Specifically, the composition for improving or increasing skin radiance or transparency, according to the present disclosure, improves barrier function by increasing KRT10 expression in the epidermal layer and at the same time, maintains stemness by recovering KLF4 expression, and suppresses collagen degradation by inhibiting MMP-1 expression in the dermal layer, and thus, by acting on both the epidermal layer and the dermal layer, can effectively reduce deterioration in skin radiance or transparency which is caused by uneven skin layers due to aging.

The ultrasonic device for skin treatment, according to this invention, comprises of the external part consisting of the body of the device (2) where the middle of the body of the device (2) is installed with a light (3) for indicating the operation status of the device, the switch (4) for turning on and turning off the device and the mechanism parts which consists of the source of energy (6) that connects to the circuit control panel (7) contained with the short circuit detection circuit (8), the Bluetooth and / or Wi-Fi receiver and transmitter (9) and the skin temperature monitoring circuit (10). The circuit control panel (7) delivers the electric current to the electromagnetic electrodes (11), the electrical muscle stimulation electrodes (12) and the ultrasonic transducer (1) consisting of the deeper focal length ultrasonic transducer (17) and the shallower focal length ultrasonic transducer (13). Both of the transducers consist of the electrodes connecting to the piezo electric material for delivering the electricity to the piezoelectric material and the solid or semi-solid material such as polymer, metal or gel, which is ultrasonic transmittable for intensifying the ultrasonic wave into the desired skin layer. There is the temperature monitoring probe (21) near the ultrasonic transducer (1) which is connecting to the temperature monitoring circuit (8).

A surgical abdomen opening and closing training model comprises a model upper body, an abdomen opening and closing simulation mechanism is arranged on the abdomen of the model upper body, foaming filler is arranged on the inner side of the front end of the model upper body, and double-branch moving mechanisms are installed on the two sides of the model upper body; the top of the model upper body is provided with a model head, the center of the top of the model upper body is provided with a head slot, and the bottom of the model head is fixedly connected with a head connecting seat. Various requirements of abdomen opening and closing training are comprehensively met, and a more real and comprehensive training environment is provided for trainees.

The invention discloses a multi-gradient step-by-step degradation micro-nanofiber artificial tendon scaffold which is of a multi-layer skin-core structure which is formed by winding and coating a plurality of layers of nanofiber membranes layer by layer and is provided with a core layer and a plurality of skin layers, the plurality of layers of nanofiber membranes are synthetic polymer / natural polymer blended micro-nanofiber membranes with different proportions, and the synthetic polymer / natural polymer blended micro-nanofiber membranes are obtained by performing an electrostatic spinning process on a blended spinning solution formed by mixing a synthetic polymer and a natural polymer according to different proportions; the winding and coating rule of the synthetic polymer / natural polymer blended micro-nano fiber membrane in the multi-layer skin-core structure is that the proportion of the synthetic polymer is gradually reduced from the core layer to each skin layer. The method not only can truly simulate an extracellular matrix and provide a favorable environment for cell repair and regeneration, but also can provide continuous mechanical support for regenerated tissues in a long period of tendon repair, and is suitable for industrial production and worthy of popularization and application.

The invention discloses a skin model and hair analyzer-based wash care product efficacy evaluation system, which comprises the steps of constructing a multi-layer skin model and calculating a matching degree coefficient, setting data acquisition point density and detecting related skin indexes according to the matching degree coefficient, meanwhile, calling an atomic force microscope and a multispectral imaging fusion technology to analyze a hair structure, and then, calculating the efficacy of a wash care product according to the analysis result of the atomic force microscope and the multispectral imaging fusion technology. Combining the data, calculating efficacy evaluation indexes according to preset weights, comparing thresholds, and finally converting into a visual chart and writing an evaluation report. According to the skin model and hair analyzer-based wash care product efficacy evaluation system, a multi-layer skin model architecture is constructed by acquiring biological material parameters of a simulated skin structure, the multi-layer skin model architecture is compared with real skin physiological indexes to calculate a matching degree coefficient, and data acquisition point density is set according to the coefficient; accurate detection and dynamic variable quantity calculation of skin model moisture penetration depth, component absorption rate and skin surface physiological index change data under the action of the washing and care product are realized.

The invention relates to a microneedle platform that enables rapid and safe immune reaction assessment by single application of allergens contained in microneedle-containing islets (2) positioned at certain intervals on a biocompatible material developed for use in allergy skin tests. Unlike the methods used in the art, the inventive microneedle platform, which enables the simultaneous application of different allergens, also enables immune cells in different layers of the skin to react against allergens with microneedles of varying sizes within the unit microneedle area.

The invention discloses a construction method and application of an animal skin injury model, and relates to the technical field of biomedicine. According to the construction method, based on the microneedle technology, through the integrated design of parameter quantification control, operation standardization, injury form customization and recovery cycle regulation and control, precision, diversification and standardization of the animal skin injury model are achieved. According to the method, unified operation specifications are formulated by relying on a quantifiable parameter system of a sterile fixed microneedle and combining animal skin characteristics, it is ensured that the damage depth / area deviation of models of the same batch and different batches is controllable, and stable construction of the animal standardized skin damage model is achieved; accurate control of'epidermis-dermis' layered gradient injury is realized through accurate matching of microneedle parameters and skin levels; according to the invention, polymorphic injury customization is also realized: diversified injury types are generated through combination of an operation mode and microneedle parameters; and key design of continuous damage and recovery period regulation and control.

The application discloses a kind of simulation dinosaur three-dimensional modeling optimization method and system, method constructs rigid body skeleton system based on Lagrange dynamics;According to the muscle layer of super-elastic material of anatomical attachment point, the displacement field is calculated using position-based dynamics method;Skin layer is constructed outside, Cauchy stress is projected to grid vertex, and wrinkle and scale texture are dynamically generated according to principal strain;The grid simplification degree and physical simulation accuracy of corresponding area are dynamically adjusted by calculating perceptual importance weight;Establish the quadratic programming problem with anatomical constraint to realize motion reorientation and angular momentum distribution;And construct deformation prediction cache model to carry out online constraint correction.The application realizes the unity of high-precision biological feature restoration and high-efficiency real-time rendering.

The invention belongs to the technical field of biological medicines and cosmetics, and particularly relates to a cationic lipid nanoparticle with repairing and permeation promoting functions as well as a preparation method, a product and application of the cationic lipid nanoparticle. The cationic lipid nanoparticles are prepared from the following components in percentage by mass: 5 percent to 40 percent of grease, 0.1 percent to 5 percent of sterol, 0.5 percent to 10 percent of lecithin, 0.05 percent to 0.5 percent of sphingosine, 0.05 percent to 0.5 percent of polyhydroxy acid, 2.5 percent to 20 percent of polyhydric alcohol and the balance of water. The zeta potential absolute value of the cationic lipid nanoparticles is larger than 40, and the cationic lipid nanoparticles are not prone to aggregation and high in stability; the lipid nanoparticles can be used for wrapping fat-soluble active matters, improving the stability of the active matters, promoting the transdermal permeation and absorption of the active matters and increasing the retention amount of the active matters in a skin layer, and have wide application value in cosmetics.

The invention relates to a skin-like chip simulation platform based on a microfluidic technology. The skin-like chip simulation platform sequentially comprises a skin-like layer, a skin-like layer, a cytoplasm matrix simulation layer and an interstitial fluid circulation layer from top to bottom, a hole array is arranged on the imitated skin layer; an interstitial fluid enrichment cavity communicated with the hole array is formed in the simulated cortex, and the interstitial fluid enrichment cavity is provided with an enrichment outlet and an enrichment inlet; an interstitial fluid micro-channel is arranged in the cytoplasm matrix simulation layer, one end of the interstitial fluid micro-channel is communicated to the enrichment inlet, and the other end of the interstitial fluid micro-channel is communicated to the interstitial fluid flowing layer; an interstitial fluid storage cavity is formed in the interstitial fluid circulation layer and is provided with a storage cavity outlet and a storage cavity inlet; the device further comprises an interstitial fluid circulation channel. The skin-like chip simulation platform designed by the invention can accurately simulate the human skin environment, provides a simulation test platform for novel extraction electrode design, parameter optimization and safety evaluation of a counter ion electroosmosis technology, and remarkably reduces the preclinical research risk and cost of new technology development.