32 results about "Layers skin" patented technology

The invention relates to the technical field of functional nutritious food, in particular to multi-layer skin nutrition powder with a whole-spectrum skin growth and repair promoting effect and a preparation method and application thereof, the core of the multi-layer skin nutrition powder is composed of a collagen peptide system (60-62%), a proteoglycan system (20-22%) and the like, collagen peptide is compounded with three sources of cattle, fish and chicken, and the multi-layer skin nutrition powder has the advantages that the multi-layer skin nutrition powder is prepared; according to the present invention, with the combination of the following components, the skin structure and activity are jointly promoted by using the synergistic effect of the functional polypeptide compound (2.5-3.5%) and the plant active component (3.5-4.5%) rich in asiaticoside and procyanidine, and the nutrition enhancers (4-5%) such as L-ascorbic acid and amino acid chelated zinc and the food-grade auxiliary materials (8-10%) such as microcrystalline cellulose are integrated in the formula, such that the various systems achieve the synergistic effect so as to achieve the effect of nourishing the skin; through the synergistic compatibility of the three-source collagen peptide, the comprehensive supplement of various types of collagen in skin tissues is realized.

The invention relates to a composition for skin care. In particular, the present invention relates to a skin care composition comprising a myrrh resin extract and a retinoid. The invention also relates to a method for treating the skin using said composition and to a method for enhancing the anti-aging effect of retinoids in the skin layer.

The utility model belongs to the technical field of multi-layer egg roll production, and particularly relates to a multi-layer egg roll production line which comprises a multi-layer wrapper forming machine, a multi-layer wrapper splitting machine is arranged on the right side of the multi-layer wrapper forming machine, and a double-layer conveyor is arranged on the right side of the multi-layer wrapper splitting machine. According to the scheme, through the arrangement of the multi-layer skin forming machine, egg skin primary pulp can be quickly processed into multi-layer skins, the multi-layer skins can be cut into lengths according to requirements under the action of the multi-layer skin cutting machine, all sections of the multi-layer skins can be pulled apart by a certain distance under the action of the double-layer conveyor, and the multi-layer skins can be cut into different lengths under the action of the plane smearing machine. Cream can be evenly smeared on each section of multi-layer skin, under the action of the tracking smearing machine, the front end of each section of multi-layer skin can be smeared with a piece of transverse cream so as to prevent hollowness during rolling, finally under the action of the multi-layer roll forming machine, the front end of each section of multi-layer skin can be rolled up by a roll head, each section of multi-layer skin is subjected to rolling forming, and a finished product is output. And the production efficiency is improved.

The invention relates to imitation body equipment, a testing system and a testing method, and the imitation body equipment comprises an imitation skin layer; the signal simulation layer is embedded in the bionic skin layer; and the control assembly is connected with the signal simulation layer and used for driving the transmissivity of the signal simulation layer to change based on a reference physiological signal so as to simulate the reference physiological signal.

The invention relates to the technical field of microneedle transdermal drug delivery, in particular to a puncture depth self-adaptive microneedle system. The microneedle system comprises a microneedle array used for puncturing skin, providing a sampling point for detecting skin impedance at a skin layer touched by a needle tip of the microneedle array, and releasing drugs; the detection unit is connected with the microneedle array and is configured to acquire skin impedance at the sampling point in a short pulse mode and output a control signal when it is judged that the needle tip of the microneedle array penetrates through the cuticle according to the skin impedance; the execution unit is respectively connected with the microneedle array and the detection unit and is configured to receive a control signal from the detection unit to stop the microneedle array from continuously puncturing into the skin after the detection unit judges the penetration, so that the penetration depth of the microneedle can be actively limited based on the electrical characteristic change of the skin in the penetration process of the microneedle; the problem of skin individual difference is effectively solved, and the active recognition capability and the automatic adjustment capability of the real-time penetration state are achieved.

The application relates to a recombinant type I collagen and application thereof, which utilizes the characteristics of Pichia pastoris capable of secreting and expressing recombinant proteins, secretes the recombinant type I collagen on the culture medium supernatant, and reduces the difficulty of protein purification. In addition, the integrin site RGD is inserted into the collagen to form a recombinant type I collagen with high stability and high expression. According to the relative proliferation of cells and the relative adhesion experiment of cells, it can be seen that the recombinant type I collagen has the effects of promoting the proliferation of skin fibroblasts, improving the skin, promoting wound healing, promoting the adhesion of fibroblasts in the skin layer and the like. Therefore, the recombinant type I collagen has great potential applications in the fields of skin care and beauty, medical treatment and the like.

A hydration level tracking system and method measures microwave energy accepted by skin in a desired target area of a user or patient in order to determine, in real time and in vivo, representative hydration levels. A measurement unit comprises a transmitter operatively connected to an antenna to deliver energy towards appropriate layer. The measurement unit determines an accepted energy power value of the skin associated with the desired target area. This measurement energy power value is compared with a calibration value, and the difference is used to determine a representative hydration level value. The determined hydration value may further be acclimatized using additional sensed values compensating for biological and ambient factors relevant to the patient. The final determined hydration level value can be displayed for reading and / or transmitted and stored for recording for further reference.

The disclosure relates to a simulated tissue useful as a surgical training aid, the simulated tissue including at least the following: (a) a skin layer, (b) a fat layer, (c) a muscle layer, (d) a first mesh, (e) an interstitial layer, (f) a second mesh, (g) a structural layer incorporating one or more anatomical components, and (h) a base layer. Methods for constructing the simulated tissue are also disclosed. The simulated tissues described herein can be used as a soft tissue surgical task trainer for numerous surgical procedures.

The invention discloses a wearable anti-hair-loss hair growth monitoring device and system based on low-power ultrasound, and relates to the technical field of hair growth monitoring and treatment. Comprising an individual structure sensing and modeling module used for collecting ultrasonic monitoring data in real time and carrying out data preprocessing; evaluating the thickness of a fat layer and the thickness of a skin layer, and constructing a curvature estimation model; the sound field simulation and sound intensity prediction module is used for judging the local ultrasonic sound intensity of the hair follicle layer, performing graded ultrasonic regulation and control and calculating a sound intensity correction factor; the individualized self-adaptive regulation and control module is used for updating sound wave transmitting power, collecting temperature data in real time and evaluating local temperature rise safety; and the monitoring feedback and system self-learning module is used for carrying out scalp state analysis feedback and realizing algorithm and threshold optimization. The problem that safe and effective transmitting power cannot be uniformly preset due to the fact that the sound intensity of the same ultrasonic power in a hair follicle layer is too high or insufficient due to the fact that the scalp thickness, fat layer and bone surface curvature difference of different users is large is solved.

The ultrasonic device for skin treatment, according to this invention, comprises of the external part consisting of the body of the device (2) where the middle of the body of the device (2) is installed with a light (3) for indicating the operation status of the device, the switch (4) for turning on and turning off the device and the mechanism parts which consists of the source of energy (6) that connects to the circuit control panel (7) contained with the short circuit detection circuit (8), the Bluetooth and / or Wi-Fi receiver and transmitter (9) and the skin temperature monitoring circuit (10). The circuit control panel (7) delivers the electric current to the electromagnetic electrodes (11), the electrical muscle stimulation electrodes (12) and the ultrasonic transducer (1) consisting of the deeper focal length ultrasonic transducer (17) and the shallower focal length ultrasonic transducer (13). Both of the transducers consist of the electrodes connecting to the piezo electric material for delivering the electricity to the piezoelectric material and the solid or semi-solid material such as polymer, metal or gel, which is ultrasonic transmittable for intensifying the ultrasonic wave into the desired skin layer. There is the temperature monitoring probe (21) near the ultrasonic transducer (1) which is connecting to the temperature monitoring circuit (8).

The invention discloses a construction method and application of an animal skin injury model, and relates to the technical field of biomedicine. According to the construction method, based on the microneedle technology, through the integrated design of parameter quantification control, operation standardization, injury form customization and recovery cycle regulation and control, precision, diversification and standardization of the animal skin injury model are achieved. According to the method, unified operation specifications are formulated by relying on a quantifiable parameter system of a sterile fixed microneedle and combining animal skin characteristics, it is ensured that the damage depth / area deviation of models of the same batch and different batches is controllable, and stable construction of the animal standardized skin damage model is achieved; accurate control of'epidermis-dermis' layered gradient injury is realized through accurate matching of microneedle parameters and skin levels; according to the invention, polymorphic injury customization is also realized: diversified injury types are generated through combination of an operation mode and microneedle parameters; and key design of continuous damage and recovery period regulation and control.

The application discloses a kind of simulation dinosaur three-dimensional modeling optimization method and system, method constructs rigid body skeleton system based on Lagrange dynamics;According to the muscle layer of super-elastic material of anatomical attachment point, the displacement field is calculated using position-based dynamics method;Skin layer is constructed outside, Cauchy stress is projected to grid vertex, and wrinkle and scale texture are dynamically generated according to principal strain;The grid simplification degree and physical simulation accuracy of corresponding area are dynamically adjusted by calculating perceptual importance weight;Establish the quadratic programming problem with anatomical constraint to realize motion reorientation and angular momentum distribution;And construct deformation prediction cache model to carry out online constraint correction.The application realizes the unity of high-precision biological feature restoration and high-efficiency real-time rendering.

The invention relates to a composition for skin care. In particular, the present invention relates to a skin care composition comprising a myrrh resin extract and a processed oat component. The invention also relates to a method for treating the skin using said composition, and to a method for activating lipid production in the skin layer.

The invention relates to the technical field of skin care products, and particularly discloses a high-activity collagen skin care product based on a pharmaceutical-grade process and a preparation method thereof.The preparation method of the skin care product comprises the steps that collagen is dispersed in deionized water and then subjected to low-temperature directional enzyme digestion and medium-temperature deep enzymolysis, and a collagen peptide solution is obtained; and adding a polyhydroxy polymer and an auxiliary gelling agent, carrying out ultrasonic treatment to obtain composite nano sol, adding a cross-linking agent, carrying out a reaction, quenching, carrying out ultrafiltration purification, and adjusting the pH value to obtain the high-activity collagen skin care product based on the pharmaceutical-grade process. According to the preparation method disclosed by the invention, the problems that the collagen is easy to inactivate and difficult in transdermal penetration are effectively solved through the cooperation of an ultrasonic cavitation effect and a nano coating technology, meanwhile, the pharmaceutical-grade purity (greater than or equal to 96%) and the biological safety of the product are ensured by utilizing a precise enzymolysis and safe crosslinking process, and effective penetration and long-acting active release of the collagen in a DEJ layer of the skin are realized.

The application discloses a scar-removing microneedle body and a scar-removing microneedle composite patch, and belongs to the technical field of microneedle patches. The scar-removing microneedle composite patch comprises a patch layer and a microneedle layer. The patch layer comprises a silica gel layer and a substrate layer, and the substrate layer is arranged between the microneedle layer and the silica gel layer. The microneedle layer comprises a plurality of microneedle bodies. The microneedle body comprises an epidermis section and a dermis section. The epidermis section is composed of a matrix and a first scar-removing component. The dermis section is composed of a matrix and a second scar-removing component. The scar-removing microneedle body in the application is designed in a two-section structure, two scar-removing components are combined, and different scar-removing components targeted to the epidermis layer and the dermis layer are accurately provided to the target skin layer. The individual scar-removing components can be concentrated in the target skin layer, and the side effects or interference of the scar-removing components in different skin layers can be avoided, so that the accurate and efficient composite scar-removing effect is achieved.

The invention relates to the field of magnetic control micro-robots, in particular to a magnetic control drug-loaded robot for thrombus removal and treatment and a preparation method of the magnetic control drug-loaded robot. The magnetic control medicine carrying robot comprises a magnetic control robot body and a medicine carrying layer. The magnetic control robot body comprises a magnetic composite layer and a spiny skin layer. The medicine carrying layer is adhered to the surface of a magnetic composite layer of the magnetic control robot. The magnetic control medicine carrying robot carries the medicine carrying layer to be navigated to a target thrombus position in a blood vessel in a rolling or spiral movement mode, then a high-frequency rotating magnetic field is applied, the rolling movement or spiral movement speed of the magnetic control medicine carrying robot is increased accordingly, the spinous skin layer of the robot continuously rubs and collides with the thrombus, and medicine of the medicine carrying layer is released; the thrombus is broken, broken fresh platelets are taken away along with blood, fibrous protein is firmly attached to a spinous skin layer, thrombus fragments can be prevented from blocking other blood vessels, and the thrombus removing effect of the robot physical effect and drug therapy is achieved.

The application discloses a painless rib taking system and method based on a multi-layer separation and precise analgesic path, and belongs to the technical field of computer-aided path planning. A skin layering collection module acquires skin multi-layer structure data of a target region, and a pain sensitivity analysis module extracts pain response parameters of each skin layer; a multi-layer separation trajectory generation module generates a separation trajectory passing through each skin layer according to the skin layering data, and a precise analgesic path planning module generates an analgesic path with layer-specific release depth intervals according to the pain response parameters; a path adjustment decision module detects spatial conflicts between the separation trajectory and the analgesic path, and selects to adjust the interlayer transition point coordinates of the separation trajectory or the depth intervals of the analgesic release sites, so that the adjusted separation trajectory maintains a safe distance from all analgesic release sites. Through the layering perception and collaborative adjustment mechanism, the spatial coordination of the separation trajectory and the analgesic path is realized, and a reliable path control basis is provided for painless operation.

A computer-implemented method for segmenting a cross-sectional skin image, comprising: obtaining (12, 50) the cross-sectional skin image; processing (20, 54) the cross-sectional skin image, said processing including edge detection on the image and / or image contrast enhancement; segmenting (22, 60) the processed image by an unsupervised classifier to identify one or more skin layers. Figure for the abstract: Fig. 1

The invention discloses dynamic noninvasive blood glucose monitoring equipment based on fusion of multi-wavelength PPG and body temperature sensing, and relates to the technical field of noninvasive blood glucose monitoring, the equipment comprises an equipment shell, and a multi-wavelength PPG signal acquisition module, a body temperature sensing module, a signal processing module and a power management module which are arranged on the equipment shell, the multi-wavelength PPG signal acquisition module adopts at least three light sources with specific wavelengths which respectively correspond to characteristic absorption wavebands of an epidermal layer, a dermal papilla layer and a dermal reticular layer, and the layered blood volume contribution factor calculation unit quantifies contribution degrees of capillary networks of different skin layers to the total blood volume; a dynamic adaptive weight distribution unit dynamically distributes fusion weights for PPG signals of all wavelengths; the blood glucose calculation unit calculates the blood glucose concentration based on the fusion signal through a multi-branch CNN-BiLSTM mixed neural network, the equipment can overcome physiological interference such as body temperature fluctuation and movement, the precision and continuity of noninvasive blood glucose monitoring are improved, and the equipment is suitable for dynamic blood glucose monitoring of diabetic patients.

An extraction device, including a motor, a driveshaft operatively coupled to the motor and driven to rotate thereby, a punch tool directly coupled to a distal end of the driveshaft to rotate therewith, and arranged to be in physical contact with a skin layer during operation of the extraction device, a force sensor operatively coupled to the driveshaft to measure a force exerted thereupon by the skin layer, and a controller communicatively coupled to the motor and to the force sensor. The controller is configured to define multiple rotary modes and multiple multiphasic modes, each multiphasic mode including at least two rotary modes, receive a selection of a multiphasic mode, and provide, based on the selection, a control signal to the motor instructing the motor to operate in the multiphasic mode.

The invention relates to the technical field of polymer composite materials, and discloses a preparation method of a bionic body with a layered structure, which adopts a two-step injection molding process: injecting a blood-meat layer raw material containing an inhibitor catalyst compound into a mold, and heating to a semi-cured gel state at a lower temperature; then, injecting a skin layer raw material containing a disulfide bond bridging cross-linking agent and up-conversion nanoparticles, and heating the mold to a relatively high temperature for overall co-curing; by regulating and controlling the material formula, the finally cured skin layer has the shore hardness of 20A-40A, the blood meat layer has the shore hardness of 0A-20A, and the bionic gradient structure with hard outside and soft inside endows the product with excellent wear resistance and impact resistance, so that the product is not easy to be injured; besides, a disulfide bond bridged dynamic cross-linking agent is introduced into the skin layer raw material, so that the skin material has the potential of self-repairing under the excitation of external energy, and the service life of the product is further prolonged.

The invention provides virtual and real combined teaching equipment for invasive arterial puncture, and relates to the technical field of virtual simulation teaching, and the equipment comprises a puncture simulation module which comprises a skin layer, a muscle layer and a blood vessel layer which are made of a 3D printing silica gel material; the skin disinfection module comprises a capacitive disinfection array and a force sensing array; the VR scene simulation module is used for updating a VR scene, synchronously establishing a module feedback signal and executing real-time training data updating; and the training recording module is used for outputting a training data set. The technical problems that in traditional invasive arterial puncture teaching, virtual simulation and actual operation links are separated, training feedback is not real-time, and teaching data are difficult to quantify can be solved, and the purposes of integrating the VR technology, the 3D printing silica gel material, wireless transmission, data collection and feedback and the like are achieved. And the technical effects of sense of reality, interactivity and accuracy of teaching are improved.

The utility model discloses a drilling positioning device, and particularly relates to the technical field of drilling positioning, the drilling positioning device comprises a mounting rack, a positioning assembly I and a positioning assembly II, the positioning assembly I comprises a support, a cylinder is rotatably arranged in the support, mounting holes which are opposite in pairs are formed in the outer wall of the cylinder, and the positioning assembly II comprises a positioning assembly I and a positioning assembly II; wherein a detachable motor and an infrared positioner are fixedly arranged in the two mounting holes respectively, a detachable drill bit is fixedly arranged on an output shaft of the motor, and the support is connected with the mounting frame through an adjusting assembly. A doctor is helped to quickly determine the drilling position through the infrared positioner, meanwhile, the positioning barrel is attached to a skeleton, the secondary positioning effect can be achieved, the skeleton can be separated from a skin layer, the skin layer is prevented from being accidentally injured during drilling, and the skin layer is prevented from being inflamed and swollen due to the fact that bone scraps generated during drilling are burst into the skin layer; and the drill bit is driven by the adjusting assembly and the motor to rotate and move downwards to drill holes in the bone, and inaccurate positioning of manual drilling is avoided.

The present application relates to the technical field of microneedle transdermal drug delivery, and in particular to a microneedle system with self-adaptive penetration depth. The microneedle system comprises: a microneedle array for penetrating the skin, providing a sampling point for detecting the skin impedance at the skin layer touched by the needle tip, and releasing drugs; a detection unit connected with the microneedle array, configured to obtain the skin impedance at the sampling point in a short pulse mode, and output a control signal when judging that the needle tip of the microneedle array has penetrated the stratum corneum according to the skin impedance; and an execution unit connected with the microneedle array and the detection unit respectively, configured to receive the control signal from the detection unit to stop the microneedle array from continuing to penetrate the skin after the detection unit determines the penetration. In this way, the microneedle penetration depth can be actively limited based on the change in the electrical properties of the skin during the microneedle penetration process, effectively addressing the problem of individual differences in the skin, and the system has the active identification ability and automatic adjustment ability of the real-time penetration state.

This invention discloses a surgical diagnosis and training model and its preparation method, comprising a supporting framework layer, a simulated subcutaneous tissue layer, a silicone skin layer, a meridian marking module, and a lesion simulation module. The simulated subcutaneous tissue layer is wrapped around the supporting framework layer, and the silicone skin layer covers the simulated subcutaneous tissue layer. The silicone skin layer has a Shore hardness of 35-40 degrees to simulate the texture of adult skin. The meridian marking module is set on the surface of the silicone skin layer to present the surface pathways of the twelve regular meridians and the location of acupoints. The lesion simulation module is integrated into the silicone skin layer and / or the simulated subcutaneous tissue layer to simulate the lesion morphology and pathological characteristics of at least one typical surgical disease in traditional Chinese medicine. This invention integrates meridian differentiation with lesion identification, realizing integrated training of "lesion observation - meridian differentiation - practical treatment", which is suitable for teaching and skills training in traditional Chinese medicine surgery.

A wearable sensing garment for sensing ultrasound waves from a body part is provided. The sensing garment includes a mesh of fabric adapted to be worn on at least a body part of a wearer; and a plurality of ultrasound sensors disposed on the mesh fabric, wherein each of the plurality of ultrasound sensors are adapted to detect ultrasound waves returned from the at least a body part of the wearer and further adapted to transmit at least portion of the detected ultrasound waves to a controller communicatively connected thereto, and wherein only a portion of the plurality of ultrasound sensors that is larger than a predetermined number of ultrasound sensors is substantially in contact with a skin layer of the at least a body part.

The application discloses a skin temperature prediction method based on a multi-node sleep thermal regulation human body model and belongs to the field of human body thermal comfort prediction. The method comprises the following steps: inputting an environmental temperature, an environmental humidity and a local clothing thermal resistance into a sleep thermal regulation human body model, and calculating a whole body skin temperature by the sleep thermal regulation human body model based on the input data. The sleep thermal regulation human body model divides a human body into six segments, i.e., a head, a trunk, an arm, a hand, a leg and a foot, and each segment comprises four layers from inside to outside, i.e., a core layer, a muscle layer, a fat layer and a skin layer, and each layer is a node, and in addition, a central blood node is further included, so as to form a 25-node sleep human body model. The application can be used for predicting the temperature distribution of each body part of a human body under different indoor environments and clothing conditions when sleeping, the prediction result is close to the actual human body experimental measurement result, time-consuming and high-cost human body experiments are avoided, and the thermal comfort of indoor environment regulation and home textile product use can be judged.

A computer-implemented method for the segmentation of a cross-sectional skin image, comprising: - obtaining (12, 50) the cross-sectional skin image; - processing (20, 54) the cross-sectional skin image, said processing comprising edge detection on the image and / or contrast enhancement of the image; segmenting (22, 60) the processed image by an unsupervised classifier to identify one or more skin layers.

To provide a method for simply evaluating the progress state of skin aging from the skin.SOLUTION: By using, as an index, the expression level of mRNA, which is an expression product of a gene encoding a protein of a DNA damage repair enzyme, collected from the skin of a test subject by a tape strip or the like capable of noninvasively obtaining a skin sample without pain or the like at the time of obtaining a sample, it is possible to predict various progression states of skin aging such as the amount of collagen in the papillary dermis, elasticity, wrinkles / sagging, brightness, the amount of melanin, blood hemoglobin oxygen saturation, color unevenness, TEWL, the amount of moisture in the stratum corneum, and the roughness of the skin surface. If the progression state of skin aging can be predicted, it is possible to present a method of using cosmetics corresponding to the prediction, and skin aging can be prevented and improved.SELECTED DRAWING: Figure 1

This application relates to a method, apparatus, and beauty device control system. The method includes: controlling the application of an electrical signal of a target frequency to the detection electrode of the beauty device; acquiring the target frequency electrical signal applied to a target skin layer and detecting the bioimpedance data of the target skin layer; determining the skin state based on the bioimpedance data; determining the target output parameters of the excitation electrode based on the skin state; and controlling the excitation electrode of the beauty device to operate with the target output parameters. Since the output parameters of the excitation electrode are determined based on the detection results of the detection electrode, the output parameters of the excitation electrode can be adjusted in real time according to the bioimpedance detection results, thus achieving automatic adjustment of the beauty device's output parameters based on the skin state.