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Large-pore-wall cage-shaped silica hollow sphere and preparation method thereof

A technology of silica and hollow spheres, applied in the directions of silica and silica, can solve the problems of inability to deliver drugs to the target site, agglomeration of hollow spheres, harsh synthesis conditions, etc., and achieve uniform and adjustable pore size distribution. Low cost, good dispersion effect

Inactive Publication Date: 2012-03-21
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above-mentioned methods are complicated in steps, harsh in synthesis conditions, a large amount of harmful gas will be generated when the organic template is removed by calcination (such as PS spheres, etc.), and the obtained hollow spheres are seriously agglomerated, which greatly limits the development of mesoporous SiO. 2 Practical application of hollow sphere
Especially as a carrier for drug delivery, the agglomeration phenomenon is a shortcoming that must be overcome, because it is reported that the agglomerated nanoparticles are easily blocked by the physical barrier of the human body, so that the therapeutic drug cannot be delivered to the target site

Method used

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  • Large-pore-wall cage-shaped silica hollow sphere and preparation method thereof
  • Large-pore-wall cage-shaped silica hollow sphere and preparation method thereof
  • Large-pore-wall cage-shaped silica hollow sphere and preparation method thereof

Examples

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Effect test

Embodiment 1

[0038] Mix 71.4mL absolute ethanol, 10mL deionized water and 3.14mL ammonia water (mass concentration: 25-28%), stir at 30°C for 30min; quickly add 6mL tetraethyl orthosilicate, and magnetically stir for 1h; After 5mL tetraethyl orthosilicate and 2mL octadecyltrimethoxysilane were uniformly mixed, the above solution was quickly added, stirred magnetically for 1h, and the product was centrifuged to obtain highly dispersed solid core / mesoporous shell SiO 2 ball. The centrifuged product is dispersed with 0.6mol / L Na 2 CO 3 in solution. The dispersed sol was stirred at 80° C. for 4 h. After centrifugation, the product was washed 3 times with deionized water, dried at 100°C for 6h, and then calcined at 550°C for 6h to remove the surfactant, and the obtained cage-shaped SiO with large pore walls 2 particle.

[0039] The SiO obtained in this example 2 The transmission electron microscope image of the particle is shown in figure 1 As shown, it can be seen from the figure that t...

Embodiment 2

[0041] Mix 142.8mL absolute ethanol, 20mL deionized water and 3.14mL ammonia water (mass concentration: 25-28%), stir at 30°C for 30min; quickly add 6mL tetraethyl orthosilicate, and magnetically stir for 1h; After 5mL tetraethyl orthosilicate and 3mL octadecyltrimethoxysilane were evenly mixed, the above solution was quickly added, stirred magnetically for 1h, and the product was centrifuged to obtain highly dispersed solid core / mesoporous shell SiO 2 ball. The centrifuged product is dispersed in 0.6mol / L Na 2 CO 3 in solution. The dispersed sol was stirred at 80° C. for 4 h. After centrifugation, the product was washed three times with deionized water, dried at 100°C for 6h, and then calcined at 550°C for 6h to remove the surfactant.

[0042] The SiO obtained in this example 2 The transmission electron microscope image of the particle is shown in image 3 As shown, it can be seen from the figure that the cage SiO 2 The particle size of the particles is 200nm, indicati...

Embodiment 3

[0046] According to the synthesis process of Example 1, the solid core / mesoporous shell SiO is first obtained 2 ball. After centrifugation, the product is dispersed in 0.6mol / L Na 2 CO 3 solution and treated at 80°C for 0.5h. Subsequent processing is the same as in Example 1.

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Abstract

The invention relates to a large-pore-wall cage-shaped silica hollow sphere and a preparation method thereof. A spherical wall of the silica hollow sphere is of a mesoporous structure, and the aperture of mesopores is 2.5-11nm. The preparation method comprises the steps of: firstly, synthesizing solid core / mesoporous shell SiO2 spheres with high dispersity and uniform particle sizes by using a sol-gel method and a surfactant orienting method; and then, skillfully removing solid cores in the SiO2 spheres while maintaining the completeness of the mesoporous layers of shells by performing a simple postprocessing method in an alkaline / acid solution to obtain the large-pore-wall cage-shaped SiO2 hollow spheres. The preparation method disclosed by the invention is simple and feasible, has no pollution, and is high in yield, low in cost, high in efficiency and extremely easy for industrialized production; and the prepared large-pore-wall cage-shaped SiO2 structure has wide application prospects in the fields of macromolecular medicament transportation, deoxyribonucleic acid (DNA) and small interfering ribonucleic acid (siRNA) loading and transporation, catalysis, microreactors, adsorption, separation, color spectrum and the like.

Description

technical field [0001] The invention belongs to the technical field of microporous / mesoporous / macroporous molecular sieve nanomaterials, and relates to a cage-shaped mesoporous silica hollow sphere with a macropore wall and a preparation method thereof. Background technique [0002] According to the International Union of Pure and Applied Chemistry (IUPAC), materials with a porous structure are divided into microporous materials (pore diameter less than 2nm), mesoporous materials (pore diameter between 2nm and 50nm) and macroporous materials (pore diameter greater than 50nm). ). Since 1992 MCM-41 mesoporous SiO 2 Since molecular sieves were synthesized by Mobil scientists (Nature 1992, 359, (6397), 710-712.), mesoporous SiO 2 Due to its high specific surface area, large pore volume, and uniform pore structure, the material shows broad application prospects in the fields of chemical catalysis, medicine, and nanobiotechnology. Mesoporous SiO in various morphologies 2 Among...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18
Inventor 陈雨陈航榕施剑林王楠
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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