The invention relates to a nanometer type natural biological protein bee products and manufacturing method thereof. It adopts the nanometer biological technology structure process, extracts and utilizes the pharmacody properties of the drug in the largest extent and optimize combines the supercritical extracted and purified biological active effective constituent. It has micro molecule effects for control releasing and targeting, and has duplex functions of healthy care and diet therapy for inhibiting the brain atrophy, high blood fat and diabetes. It provides a novel protection and treatment measures for lowering the blood sugar and blood fat, reversing the canceration. The invention comprises following constituents: propolis 5-50b, royal jelly 10-45b, bee pollen 15-40b, ganoderma lucidum 8-25b, gingko leaf 10-20b, aloe 8-25b, nervonic acid 4-15b, chitosan 4-10b, maple leaf 4-10b, honey suckle 10-15b, licorice 8-15b, hawthorn fruit 8-15b.(b is a weight unit)