The invention discloses a solvent resistant and weather-proofing glass bead for a reflective membrane and a preparation method of the solvent resistant and weather-proofing glass bead. The solvent resistant and weather-proofing glass bead is prepared from the following raw materials by weight: 34-46kg of silica sand, 27-39kg of glauconite, 18-34kg of talcum, 16-28kg of iolite, 24-38kg of metallurgy slag, 12-18kg of silicon boride, 10-15kg of molybdenum carbide, 8-16kg of zirconium sulfate, 5-10kg of potassium dihydrogen phosphate, 5-10kg of sodium nitrate, 4-8kg of dioctyl sodium sulfosuccinate, 3-6kg of sodium dodecyl sulfate, 2-4kg of coconut diethanolamide, 3-5kg of glycosaminoglycans, and 7-13kg of additives. Through the adding of glauconite, talcum, iolite, and metallurgy slag, the light aging and heat aging properties of the glass bead are significantly improved, and through the adding of the silicon boride, molybdenum carbide, and zirconium sulfate, the solvent resistant and wearing properties and the chemical stability of the glass bead can be improved while the mechanical strength of the glass bead can be improved. The prepared glass bead is good in solvent resistant property and weather-proofing property, high in refractive index, good in reflection effect, long in service life, and wide in application.