The invention discloses a contact fatigue-highly resistant cold-rolling intermediate roller and a manufacture method thereof, the roller comprises the following components by weight percentage: 0.70-0.85% of C, 0.40-1.00 of Si, 0.20-0.60% of Mn, 2.80-3.50% of Cr, 0.25-0.60% of Ni, 0.30-0.50% of Mo, 0.10-0.30% of V, less than or equal to 0.02 of P; less than or equal to 0.015 of S, and the balance of Fe and inevitable impurities. The manufacture method comprises the following steps: smelting in an electric furnace, refining outside the electric furnace, degassing under vacuum, casting an electrode bar, remelting electroslag, forging, annealing and performing heat treatment, roughly machining, tempering and performing heat treatment, semifinishing, performing heat treatment on the roller body, finely tempering, and acquiring the finished product roller. By reducing the content of an element C and increasing the content of Si, Ni and Mo elements, strength and toughness performance as well as the matrix strength of the intermediate roller can be increased, and tissue can be refined, and the cold-rolling intermediate roller has high contact fatigue resistance through heat treatment.