35 results about "Nicotinic Acid Amide" patented technology

The invention relates to a composition comprising vitamins and mineral substances. The composition comprises the vitamins and the mineral substances, wherein the vitamins include vitamin A, vitamin C, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinic acid amide and pantothenic acid, and the mineral substances include calcium, iron, zinc, and selenium. According to the composition, the amounts of the vitamins and the mineral substances are reasonably proportioned strictly according to the needing amounts of a human body; the mineral substance iron is supplied by ferrous fumarate, so that the destroy on the active substances, such as vitamins, by the addition of the inorganic iron can be effectively prevented; the mineral substance selenium is provided by selenium enriched beer yeast, the toxic and side effects of chemical selenium (such as sodium selenite) on the human body and intestines and stomach stimulation are eliminated, and therefore the selenium can be absorbed and utilized by the human body more efficiently and safely.

The invention belongs to the technical field of preparation of medicines which are applied to plant grafting and can promote concrescence of grafting openings, and in particularly relates to a preparation method of a plant grafting consolidant. Specifically, the consolidant consists of polyvinyl acetate latex, polyvinyl alcohol, carbendazol, 8-copper quinolinate, 6-BA (benzyl amino-purine), NAA (nicotinic acid amide) and distilled water. When the plant grafting consolidant is applied to plant grafting, the nutrient supply, sterilization and water supply of plant grafting openings are provided at the same time, and the consolidant has functions of disinfection, sterilization, corrosion prevention, water and nutrient lose prevention and the like, so that the concrescence of the grafting openings is promoted, and the survival rate of grafting is improved. Meanwhile, the preparation method has the characteristics of low cost, good effect, simplicity in application and the like, and the consolidant can be widely applied to grafting of all plants.

The invention discloses a tissue culture method for lilium tenuifolium, which comprises: sterilizing stripped lilium tenuifolium bulb serving as an explant from an intermediate scale part; and inoculating the stripped lilium tenuifolium bulb into a Murashige and Skoog (MS) medium, a first-generation induction medium consisting of 6-benzyladenine (BA) at a concentration of 1.0mg / L, nicotinic acid amide (NAA) at a concentration of 0.1mg / L and vitamin C (Vc) at a concentration of 5mg / L, a sub-generation propagation medium consisting of MS, 6-BA at a concentration of 0.2mg / L and NAA at a concentration of 0.01mg / L, a rooting medium consisting of 1 / 2of MS, and indole-3-butyric acid (IBA) at a concentration of 0.5 mg / L and bulbing culture medium consisting of 1 / 2of MS, IBA at a concentration of 0.5 mg / L and 2 percent of white sugar in turn for culture under the culture conditions including a culture temperature of 25+ / -1 DEG C, day light and 4 hours of night light supply per day. When the culture method is used, tissue culture lilium tenuifolium seedlings propagated indoor in large scale can be obtained in a short time period, the productivity is high and the potential ecological benefitand social benefit can be created.

The invention discloses a solid health-care beverage special for the female menstrual period, and relates to the field of health food. The product is prepared from the following materials in a certain proportion and through processing steps: Chinese date, longan pulp, Chinese angelica, root of red-rooted salvia, spina date seed, rose, concentrated whey protein powder, honey powder, maltodextrin, calcium lactate, magnesium carbonate, green copperas, potassium citrate, zinc gluconate, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, pantothenic acid and nicotinic acid amide. For solving the problem that the health food in the prior art cannot supplement all nutrients required in the female menstrual period, the invention provides the solid health beverage special for the female menstrual period, which has convenient eating, integrates the functions of supplementing the conventional natural fine medicinal food and supplementing the necessary nutrients in the female menstrual period, has overall balanced nutrition, combines regulation, nourishing and supplementation, can effectively improve even eliminate the female menstrual syndrome, makes women feel well every month in the menstrual period and has the effects of maintaining the skin soft and smooth, releasing the climacteric syndrome and the like.

An alopecia prevention composition consists of 0.1˜3 weight % of salicylic acid, 0.1˜5 weight % of tocopherol acetate, 0.1˜3 weight % of nicotinic acid amide, 0.1˜1 weight % of polyvinylpyrrolidone, 8˜12 weight % of ethanol, 0.3˜0.5 weight % of polyoxyethylene hydrogenerated castor oil, 0.2˜0.4 weight % of solid ginseng extract, 0.2˜0.4 weight % of peony root extract and a residual quantity of purified water.

The invention discloses a method for rapidly breeding tulip by using tulip scales. The method specifically comprises the steps of selecting plants, refrigerating, disinfecting, cutting the scales, carrying out bud forcing treatment on the scales, carrying out expansion treatment on the scales, transplanting seed balls, and the like, wherein the large tulip seed balls are firstly refrigerated before being cut, thereby achieving the remarkable effects on improving the breeding coefficients and cultivating strong seedlings; and by coating GA3 and NAA (Nicotinic Acid Amide) on small differentiated tulip scales to prompt the scales to differentiate, the time is greatly shortened, and compared with the conventional method, about one month is saved, so that the labor and the cost are reduced.

The invention provides a novel preparation method of 5-aminomethyl nicotinic acid. The method comprises steps of: reacting 5-(hydroxymethyl)nicotinate with a nitrogen source reagent under existence of a dehydrating agent to obtain 5-(phthalic diamide) methylnicotinate; hydrolyzing the 5-(phthalic diamide) methylnicotinate under acid or alkaline conditions to obtain 5-(phthalic diamide) methyl nicotinic acid; and reacting the 5-(phthalic diamide) methyl nicotinic acid with a deprotection reagent to obtain the 5-aminomethyl nicotinic acid. The method is simple in technology, mild in condition, safe in operation, and high in yield.

The invention relates to a preparation method of artificial seeds of submerged plants (hydrilla). The method comprises the following steps: 1. washing the taken hydrilla seedling with water to remove plankton on the surface of the hydrilla seedling; 2. cutting off the roots and leaves of all the plants, picking up the eugenic plants and washing the eugenic plants with distilled water; 3. cutting off the lateral buds and the terminal buds with internodes and putting the lateral buds and the terminal buds into gel liquid which is formed by mixing of sodium alginate, hoagland's nutrient solution and NAA (nicotinic acid amide); 4. dropping the gel liquid containing hydrilla buds into CaCl2 by a dropper to perform curing reaction, taking out gel liquid after the curing reaction and rinsing with sterile distilled water, and terminating the reaction to obtain the artificial hydrilla seeds. According to the method, the step of plant tissue culture is eliminated, and the method is not required to be implemented under an aseptic condition, the preparation process is greatly reduced, the cost is greatly reduced, the period is shortened, and the survival rate is high.

The invention discloses a novel synthesis process of 4-trifluoromethyl nicotinic acid. N-1-methoxy-2-methoxycarbonyl ethyl-4,4,4-trifluoro-3-one-1-butene amine is prepared from 4-amino-1,1,1-trifluoro-3-butene-2-one, and 4-trifluoromethyl nicotinic acid is obtained in a high-yield manner through one-pot ring closing hydrolysis under the action of alkali. The method can meet the industrial mass production demands due to unique novelty, higher total yield, low cost, simplicity in operation and lower equipment requirements.

The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

A preparation which can improve the dissolution property of a poorly water soluble drug even when the drug is contained in the preparation at a high content is provided.When an addition amount of nicotinic acid amide and / or urea is 0.1 to 10% by weight in a solid preparation containing a poorly water soluble drug, and a water-soluble polymer, even a poorly water soluble drug, particularly a drug having a high content can be dissolved out from the preparation by an almost all amount.

The invention discloses a method for synthesizing 6-trifluoromethyl-nicotinic acid. The method comprises the specific steps: carrying out addition-elimination reaction reactions on trifluoroacetic acid and vinyl ethyl ether under the action of phosphorus pentachloride to obtain 4-ethoxyl-1,1,1-trifluoro-3-butene-2-one; carrying out addition-elimination reaction reactions on ethidene diamine and cyanoacetic acid in a heating condition to obtain 3-(diethyl amino) acrylonitrile first; carrying out an Stork alkylation reaction on 3-(diethyl amino) acrylonitrile and 4-ethoxyl-1,1,1-trifluoro-3-butene-2-one to obtain 2-((diethyl amino) methylene)-6,6,6-trifluoro-5-oxo-3-hexenenitrile; carrying out exocondensation on 2-((diethyl amino) methylene)-6,6,6-trifluoro-5-oxo-3-hexenenitrile under the action of ammonium acetate to obtain 6-trifluoromethyl cyanopyridine; and carrying out cyano hydrolysis reaction on the 6-trifluoromethyl cyanopyridine t obtain 6-trifluoromethyl-nicotinic acid. The synthetic method is more economic, environmentally friendly, efficient and simple.

The invention discloses a tissue culture method for lilium tenuifolium, which comprises: sterilizing stripped lilium tenuifolium bulb serving as an explant from an intermediate scale part; and inoculating the stripped lilium tenuifolium bulb into a Murashige and Skoog (MS) medium, a first-generation induction medium consisting of 6-benzyladenine (BA) at a concentration of 1.0mg / L, nicotinic acid amide (NAA) at a concentration of 0.1mg / L and vitamin C (Vc) at a concentration of 5mg / L, a sub-generation propagation medium consisting of MS, 6-BA at a concentration of 0.2mg / L and NAA at a concentration of 0.01mg / L, a rooting medium consisting of 1 / 2of MS, and indole-3-butyric acid (IBA) at a concentration of 0.5 mg / L and bulbing culture medium consisting of 1 / 2of MS, IBA at a concentration of 0.5 mg / L and 2 percent of white sugar in turn for culture under the culture conditions including a culture temperature of 25+ / -1 DEG C, day light and 4 hours of night light supply per day. When the culture method is used, tissue culture lilium tenuifolium seedlings propagated indoor in large scale can be obtained in a short time period, the productivity is high and the potential ecological benefitand social benefit can be created.

The invention relates to a method for synthesizing 4-trifluoromethyl nicotinic acid, in particular to a method for synthesizing a key flonicamid intermediate 4-trifluoromethyl nicotinic acid. The method comprises the following steps: by taking 1,1,1-trifluoro-4-amino-butenone and dimethyl 2-methoxy-methylene malonate as raw materials, carrying out first-step reaction, namely carrying out reaction on 1,1,1-trifluoro-4-amino-butenone and dimethyl 2-methoxy-methylene malonate under the alkaline condition of a polar solvent, so that a first-step reaction system is obtained; carrying out second-step reaction, namely adding an alcoholic solvent into the first-step reaction system, and carrying out heating reaction, so that a second-step reaction system is obtained; and carrying out third-step reaction, namely adding acid solution into the second-step reaction system, and carrying out reaction, so that the 4-trifluoromethyl nicotinic acid is obtained. The method provided by the invention has the advantages of available raw materials, simple operation, low cost, less side reaction and high product purity and is applicable industrial production.

The invention discloses a quick-drying water-fast exterior wall coating material and a preparation method thereof. The coating material is prepared from the following raw materials in parts by weight: 50 to 80 parts of acrylic latex, 60 to 70 parts of modified alkyd resin, 20 to 50 parts of carboxymethyl cellulose, 20 to 50 parts of hydroxyethyl cellulose, 20 to 30 parts of lignocellulose, 10 to 60 parts of magnesium oxide, 10 to 20 parts of tin oxide, 50 to 60 parts of barium sulfate, 4 to 8 parts of tributyl phosphate, 10 to 15 parts of sodium dihydrogen phosphate, 20 to 30 parts of boric acid, 10 to 50 parts of polyethyoxyl, 40 to 50 parts of nicotinic acid amide and 100 to 120 parts of water. The preparation method of the quick-drying water-fast exterior wall coating material comprises the following steps of mixing all components, and then carrying out ball milling on an obtained first mixture; finally, adding the modified alkyd resin into the ball-milled first mixture, and carrying out the ball milling on an obtained second mixture for 20min to 30min, so that the quick-drying water-fast exterior wall coating material is obtained. The quick-drying water-fast exterior wall coating material is high in water resistance; the scrubbing resistance and the shock strength of the coating material are improved through the addition of the nicotinic acid amide, and the water resistance of the quick-drying water-fast exterior wall coating material is further improved to a certain extent.

The invention belongs to the technical field of plant regeneration by tissue culture techniques, and discloses a syngonium podophyllum golden regeneration system building method. An elongation mediumMS+7g / L agar+30g / L sucrose+100mg / L Vc+0.2mg / L IBA (indolebutyric acid)+0.5mg / L IAA (indoleacetic acid)+0.4mg / L PBU (phenyl butyl urea) is added into an MS medium. A rooting medium is MS+7g / L agar+30g / L sucrose+100mg / L Vc+0.5mg / L IBA, and a bud multiplication medium is MS+7g / L agar+30g / L sucrose+100mg / L Vc+1.0mg / L NAA (nicotinic acid amide)+1.0mg / L PBU. The multiplication coefficient and the rooting rate of syngonium podophyllum golden adventitious buds are increased, and elongation of the adventitious buds is promoted.

The invention relates to a yield increase element for promoting plant growth, and a production method thereof. According to the present invention, according to the yield increase element, the plant nutrition element is adopted as the main body, the yield increase element contains a plant light respiration consumption inhibitor, and the plant growth can be promoted; the yield increase element is characterized in that 4-28% by weight of sodium hydrogen sulfite, 0.5-2% by weight of sucrose, 0.2-2% by weight of citric acid, 2-15% by weight of zinc sulfate, 5-20% by weight of potassium sulfate, 20-35% by weight of magnesium sulfate, 8-50% by weight of ferrous sulfate, 5-15% by weight of boric acid and 5-10% by weight of sodium carbonate are adopted as the raw materials, wherein the nicotinic acid amide content is 0.1-1% by weight.

The invention relates to the technical field of cosmetics and particularly provides a composition capable of beautifying face and brightening skin, a skin care product capable of beautifying face andbrightening skin and a preparation method for the composition. The composition capable of beautifying face and brightening skin comprises the following effect raw materials: 0.1%-8% of lotus extract,0.5%-30% of olea europaea water and 0.05%-5% of nicotinic acid amide. The composition capable of beautifying face and brightening skin is wide in source of raw materials, all the ingredients are matched with one another and in synergism through being matched according to a proper proportion, the composition can be used for preparing local- or full-face whitening cosmetics, and the preparation method is simple and easy in operation. The skin care product containing the composition capable of beautifying face and brightening skin has the effect of clearing free radicals, provides anti-oxidationprotection for skin, meanwhile, inhibits activity of tyrosinase, has good pigment thinning and skin brightening effects on gloomy skin and pigmentation and can also be used for replenishing water, preserving moisture, improving skin texture, improving natural defense capability of skin, the skin is soft, smooth, delicate and brilliant white after using the skin care product, skin beautifying and brightening effects are achieved globally.

The invention discloses anti-pollution cream and a preparation method thereof. According to the anti-pollution cream, buckwheat seed extracts, integripetal rhodiola herb extracts, phellinus igniarius sporophore alcohol extracts, D-pantothenyl alcohol and nicotinic acid amide serve as main active components, and an excellent film-forming agent DC FA 4001 CM is added. The anti-pollution cream is uniform in color and luster, fine, smooth, easy to smear and stable in performance and has excellent oxidation resistance and inflammation resistance, PM2.5 (particulate matter) particles are effectively isolated, damage of pollutants to skins is effectively reduced, and health vitality of the skins is kept.

The invention relates to the field of daily chemicals, and discloses a whitening brightening composition. The whitening brightening composition is prepared from, by mass, 0.5-3% of nicotinic acid amide, 0.2-3% of magnesium ascorbyl phosphate, 0.1-5% of grapefruit peel oil, 0.5-2% of arbutin, 0.1-2% of undecylenoyl phenylalanine, 1-5% of a myrothamnus flabellifolia extract, 0.1-2% of hydrolyzed collagen, 0.2-5% of an adansonia diditata pulp extract, 0.1-5% of xylitol glucoside, 1-5% of a balausta extract and 5-30% of an auxiliary material. The invention also discloses a preparation method of the whitening brightening composition. The whitening brightening composition is safe and effectively, can enhance the skin barrier function, and enhance the skin compactness, delicacy, brightness and whiteness.

The invention discloses a special medicinal rhubarb organic fertilizer and a manufacturing method thereof, and belongs to the technical field of fertilizers. The organic fertilizer is prepared from, by weight, 30-40 parts of cow dung, 5-10 parts of bamboo charcoal, 2-5 parts of fulvic acid, 1-3 parts of nicotinic acid amide, 20-30 parts of chicken manure, 10-15 parts of chimney ash, 1-5 parts of attapulgite powder, 20-30 parts of bran, 20-25 parts of fish bone meal, 20-30 parts of salt, 10-15 parts of sodium carbonate, 20-25 parts of guano, 15-20 parts of sunflower straw ash, 5-7 parts of medical stone powder, 5-10 parts of carnallite, 3-7 parts of polyterpene bacillus agents, 5-8 parts of actinomycete agents, 5-7 parts of glauconite, 10-15 parts of seaweed, 5-10 parts of fatty acid, 3-10parts of dolomite, 1-3 parts of zeolite, 2-5 parts of oxalic acid and 5-8 parts of potassium salt. According to the organic fertilizer, stress resistance of medicinal rhubarb can be effectively improved, reproduction of harmful and pathogenic microorganisms in soil can be effectively restrained, the acre yield of the medicinal rhubarb can reach 742kg or more after the organic fertilizer is applied, and the incidence rate of root rot diseases of the medicinal rhubarb is lower than 27%.

The invention mainly relates to a crab meat puffing seasoning formula. The ingredients of the crab meat puffing seasoning formula comprise soybean protein isolate, starch, nicotine amide, hydrogenated castor oil, table salt, white granulated sugar, fermented soya bean powder, glucose, monosodium glutamate, sodium bicarbonate, a composite phosphate, an edible essence, a spice, and the balance water; wherein the mass amounts of the ingredients account for 2 to 3%, 0.5 to 2%, 0.01 to 0.1%, 0.1 to 1%, 1 to 2%, 0.5 to 1.5%, 0.1 to 1%, 0.1 to 3%, 0.1 to 1%, 0.1 to 0.5%, 0.1 to 0.4%, 0.02 to 0.2%, 0.05 to 3% of that of crab meat raw material.

The invention relates to a preparation method of nicotinic acid, which comprises the following steps: placing 700-900 parts of 3-cyanopyridine in a container, adding 1600-1800 parts of de-ionized water into the 3-cyanopyridine in the container, and stirring to obtain a solution; dropwisely adding 760-770 parts of 40% sodium hydroxide solution at 90-95 DEG C, and reacting for 58-62 minutes to generate a sodium nicotinate solution; diluting the solution to 15%; passing the 15% sodium nicotinate solution through an ammonium cation exchange resin layer for ion exchange at a flow rate of 300 liters per hour, collecting to obtain an ammonium nicotinate solution; and evaporating the ammonium nicotinate solution to dryness so as to obtain nicotinic acid. In the invention, 3-cyanopyridine used as the raw material reacts with the sodium hydroxide solution used as hydrolytic agent at a temperature above 90 DEG C for 58-62 minutes to obtain sodium nicotinate. Thus, compared with the prior art, the invention overcomes the defects of high equipment requirements and large equipment corrosion of the original technology, and has the advantages of simpler process, more convenient operation, less waste, lower cost and higher conversion rate.

The invention discloses a high-survival-rate cuttage method of plukenetia volubilis. The method comprises: selecting cuttings, immersing by a solution and cutting. In the step of selecting the cuttings, plukenetia volubilis tip branches are collected; the tip branches are branches growing on parts which are 1m or more away from a base part of a main stem of the plukenetia volubilis; tip branches, which are no more than 25cm far away from the base parts of the tip branches, are sheared and are used as the cuttings; the solution for immersing the cuttings is an NAA (Nicotinic Acid Amide) solution with the concentration of 50mg / L to 200mg / L; after the cuttings are immersed for 2 hours, the cutting is carried out. By adopting the method provided by the invention, the cuttage survival rate of the plukenetia volubilis can be remarkably improved and the average survival rate is stabilized to be 96 percent or more; the high-survival-rate cuttage method provides technical supports of cuttage vegetative propagation for keeping good fruitfulness, high oil content and disease resistance of female parents.

The invention relates to a boar nutrition replenisher and a preparation method thereof. The boar nutrition replenisher comprises the components based on parts by weight: 30-50 parts of vitamin A, 13-15 parts of vitamin D, 15-25 parts of vitamin E, 0.08-0.12 part of vitamin B12, 8-12 parts of nicotinic acid amide, 4-6 parts of calcium pantothenate, 55-65 parts of vitamin C, 0.08-0.12 part of biotin, 1-11.4 parts of beta-carotene, 1-2 parts of folic acid, 0.08-0.12 part of organic chromium, 8-12 parts of L-carnitine, 20-30 parts of dihydropyridine, 70-90 parts of electrolyte, 500-800 parts of oligosaccharide, 4-6 parts of lysine, 0.8-0.9 part of valine and 5-7 parts of glutamine. The invention can improve the immunity of the organism of breeding stock, conception rate, birth rate, breeding capacity and fertility rate; furthermore, solubilization and periderm are also carried out on the insoluble raw materials, so that the nutrition replenisher can be added into feed and drinking water.

The invention belongs to the field of biochemical analysis, and relates to a method for improving the ionization efficiency of oligosaccharides, especially a method for improving the ionization of oligosaccharides in matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS); the method adopts 6 ‑Hydrazine nicotinamide (HYNIC) is used as a matrix to analyze oligosaccharides, which selectively improves the ionization efficiency of oligosaccharides and inhibits the ionization of other analytes such as peptides. The 6-hydrazine nicotinamide in the present invention has the structure of formula (I); when the 6-hydrazine nicotinamide is used as a matrix to analyze oligosaccharides, it has high sensitivity, uniform crystallization, strong salt tolerance, and tandem mass spectrum fragmentation The advantages such as abundant information; The method of the present invention, adopts described 6 hydrazine nicotinamide as matrix analysis oligosaccharide, can selectively improve the ionization efficiency of oligosaccharide, and suppressed other analyte such as peptide segment Ionization has the advantages of simple operation, simple steps, economical and time-saving, and no desalination is required.

The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

The invention discloses a method for rapidly breeding tulip by using tulip scales. The method specifically comprises the steps of selecting plants, refrigerating, disinfecting, cutting the scales, carrying out bud forcing treatment on the scales, carrying out expansion treatment on the scales, transplanting seed balls, and the like, wherein the large tulip seed balls are firstly refrigerated before being cut, thereby achieving the remarkable effects on improving the breeding coefficients and cultivating strong seedlings; and by coating GA3 and NAA (Nicotinic Acid Amide) on small differentiated tulip scales to prompt the scales to differentiate, the time is greatly shortened, and compared with the conventional method, about one month is saved, so that the labor and the cost are reduced.

An accessory coating composition having a fragrance emission function is disclosed, in which a fragrance composition containing 10-hexaoxa decanolide, 11-hexaoxa decanolide or 12-hexaoxa decanolide, nicotinic acid amide and fragrance is coated on the surfaces of various accessories, so the fragrance composition-coated accessories can continuously emit fragrance for a long time.

A preparation which can improve the dissolution property of a poorly water soluble drug even when the drug is contained in the preparation at a high content is provided.When an addition amount of nicotinic acid amide and / or urea is 0.1 to 10% by weight in a solid preparation containing a poorly water soluble drug, and a water-soluble polymer, even a poorly water soluble drug, particularly a drug having a high content can be dissolved out from the preparation by an almost all amount.