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Method and system for carrying out magnetic micromanipulation on cell in physiological environment

A technique of physiological environment and micromanipulation, applied in biochemical equipment and methods, biomass post-processing, biological material pretreatment, etc., can solve unseen problems and achieve the effect of improving scanning efficiency and scanning accuracy

Active Publication Date: 2014-12-24
CHANGCHUN UNIV OF SCI & TECH
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Problems solved by technology

[0005] Since cells are basically non-magnetic, and it is difficult to manipulate biological cells in a physiological environment, there are no relevant reports on the application of micro-nano manipulation technology to the magnetic research of in vitro cells.

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  • Method and system for carrying out magnetic micromanipulation on cell in physiological environment

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Embodiment Construction

[0010] As shown in Figure 1, the magnetic micromanipulation system for cells includes a magnetic probe, a probe nano-shift detection module, a three-dimensional displacement platform, an inverted / upright optical microscope, a magnetic probe control module, a displacement control module, and environmental control System composition. The liquid pool is placed above the scanner, and a cover glass with cells is placed in the pool. The piezoelectric ceramic tube can control the independent movement of the liquid pool in the X, Y and Z directions under the action of an external voltage. The laser beam emitted by the diode laser is focused on the back of the micro cantilever through an optical system, and then reflected on the photodetector by the back of the micro cantilever. Due to the interaction force between the atoms on the sample surface and the atoms at the tip of the micro cantilever probe, when the sample is scanned, the micro cantilever will bend and undulate with the topog...

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Abstract

The invention discloses a method and a system for carrying out magnetic micromanipulation on a cell in a physiological environment. The system for carrying out the magnetic micromanipulation on the cell in the physiological environment comprises a magnetic probe, a probe nanometer offset detection module, a three-dimensional displacement platform, an inverted / upright optical microscope, a magnetic probe control module and a displacement control module and realizes the in-vitro operation and real-time tracking observation of a biological cell by being placed into a fine controlled culture environment suitable for the in-vitro growth of the cell. The method for carrying out the magnetic micromanipulation on the cell is characterized by measuring a single cell which contains magnetic nanometer particles point by point according to a selected area by utilizing the magnetic probe on the basis that the magnetic micromanipulation on the cell is combined with the magnetic nanometer particles, recording the magnitude of magnetic force, simultaneously acquiring the magnetic force and shape dot images at a nanometer scale and operating, moving, carrying, injecting and testing the single cell by using the magnetic probe by accurately positioning the magnetic cell and the magnetic nanometer particles, thereby achieving the guiding significance on a nanometer biological technology and micro-nanomanipulation technologies.

Description

Technical field [0001] The present invention relates to a cell magnetic micromanipulation method and system in a physiological environment, and its potential applications include the following scientific and technological fields: biological sciences, medicine, electronics, computer science, etc. technical background [0002] Nanoscale magnetic measurement is one of the most important nanotechnology, and its application prospects are extremely broad, especially in the field of biomedicine. [0003] In 1990, IBM's Eigler et al. used a scanning tunneling microscope to put together 35 xenon atoms on the nickel surface to form the word "IBM" under high vacuum and extremely low temperature conditions, thus realizing the relocation of atoms for the first time. In 1998, Stark et al. used atomic force microscope probes to image and cut DNA. In 2012, Kim et al. used atomic force microscopy to find that the nature of cancer cell apoptosis is related to changes in surface roughness and rigidi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N13/00C12M1/36C12M1/34
Inventor 曲英敏王作斌刘劲芸侯煜刘洋王国梁李文君翁占坤李景梅宋正勋胡贞许红梅于淼刘兰娇
Owner CHANGCHUN UNIV OF SCI & TECH
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