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Magnetic upconversion nanocomposite material with switchable magnetic components and preparation method of magnetic upconversion nanocomposite material

A nanocomposite material and magnetic technology, applied in the field of nanomaterial preparation technology and nanobiological application, can solve the problems of low luminous efficiency and inability to meet the needs of clinical biomedical applications, and achieve simple preparation methods, eliminate quenching, and improve detection The effect of sensitivity

Inactive Publication Date: 2014-07-02
NORTHEAST NORMAL UNIVERSITY
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AI Technical Summary

Problems solved by technology

Generally, magnetic materials have obvious quenching effect on up-conversion luminescence. Simply combining magnetic nanoparticles with up-conversion luminescence materials has low luminous efficiency and cannot meet the needs of clinical biomedical applications.

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0028] 1. Surface amination treatment of superparamagnetic nanoparticles

[0029] Synthesis of oil-phase Fe using known methods 3 o 4 Nanoparticles are dispersed in chloroform solution, mixed with PEI chloroform solution according to the solute mass ratio of 1:10, after stirring for 12 hours, add n-hexane, pour off the upper layer, and vacuum dry at 37°C for 10 minutes to remove residual n-hexane and chloroform, ultrasonically dispersed in 50 ml of high-purity water to obtain amino-modified superparamagnetic Fe 3 o 4 Nanoparticles.

[0030] superparamagnetic Fe 3 o 4 Nanoparticles replaced by Fe 3 o 4 or Fe 2 o 3 or CoFe 2 O or NiFeO 4 or MnFeO 4 Or Fe or FePt etc.

[0031] 2. Superparamagnetic Fe 3 o 4 Nanoparticle Surface Carboxylation Treatment

[0032] Add 10 mg superparamagnetic Fe to 80 mg PAA, 15 ml THF solution 3 o 4 Nanoparticles were stirred at 30°C for 12 hours, centrifuged and washed 3 times, and ultrasonically dispersed in 5 ml of high-purity wat...

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PUM

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Abstract

The invention belongs to the field of nanometer material preparation technologies and nanobiotechnology applications and relates to a preparation method of a magnetic upconversion nanocomposite material. According to the preparation method, a DNA molecule is used as a bridge, magnetic nanoparticles are connected with rare earth doped upconversion nanoparticles by utilizing base complementary pairing action to establish a magnetic upconversion nano-composite structure, and the structure both has superparamagnetism and upconversion luminescence characteristic. By adjusting pH value of a system, raising the temperature or adding competitive DNA to remove the magnetic nanoparticles, cancellation to upconversion luminescence by the magnetic components can be eliminated and the detection sensitivity of the upconversion luminescence characteristic can be improved. The method is simple, operation is convenient and quick, and the synthesized magnetic upconversion nanocomposite material can be applied to bio-medical fields of bioseparation, bioinstrumentation, upconversion luminescence imaging, and the like.

Description

[0001] technical field [0002] The invention belongs to the field of nanomaterial preparation technology and nanobiology application, and in particular relates to a preparation method of a magnetic up-conversion nanocomposite material with switchable magnetic components. Background technique [0003] In recent years, rare earth upconversion luminescent nanomaterials have attracted widespread attention due to their unique advantages in biomarkers, immunoassays, and in vivo imaging. The up-conversion luminescent material can be excited by near-infrared or infrared light, the energy of the excitation light is low, and it has good penetrating ability to biological tissues, which can avoid the damage to the organism caused by other fluorescent materials excited by ultraviolet light; because the labeled biomolecules Or tissues will not be excited by infrared light to generate fluorescent background noise, therefore, higher detection sensitivity can be obtained; through the select...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85C09K11/02
Inventor 洪霞刘益春丛铁
Owner NORTHEAST NORMAL UNIVERSITY
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