Hollow and hard nano capsules and their production

A technology of hollow capsules and nanometers, which is applied in the field of nanoscale hollow capsules, preparation of hollow capsules, and hollow nanocapsules. The effect of not easy to pollute

Inactive Publication Date: 2007-06-20
武兴战
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the shortcomings of gelatin hard hollow capsules that are not conducive to storage, easy to pollute, high in heavy metal content, unsuitable for hygroscopic drugs, and unable to meet the customary requirements of vegetarians and ethnic minorities.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Raw material % by weight

[0043] Refined Starch A 40%

[0044] Active Protein E 30%

[0045] Pectin 12%

[0046] Propolis 4%

[0047] Chitosan 3.5%

[0048] Potassium Chloride 3.5%

[0049] water 7%

[0050] Konjac or potato selected from plants is modified by nano-biotechnology ultra-microstructure, heavy metals are absorbed by chitosan, harmful substances are separated through synergistic copolymerization reaction, and temperature, time, process moisture and substance content are controlled.

[0051] 1. Dissolve 26 grams of active protein in 1200 mL of water for dispersion, heat treatment at 85°C for 40 minutes, adjust the pH of the solution to 10 with 0.1 N sodium hydroxide, add 40 grams of 30 nm denatured glucomannan and 3 mL of phosphorus oxychloride, and perform a copolymerization reaction 3.5 hours. Precipitate, wash, and dry to obtain the complex.

[0052] 2. Mix 32 grams of the compound with a particle size of 30nm with 575mL of water under stirring, c...

Embodiment 2

[0057] Raw material % by weight

[0058] Refined Starch B 45%

[0059] Active Protein F 25%

[0060] Pectin 10%

[0061] Propolis 5%

[0062] Chitosan 4%

[0063] Potassium chloride 3%

[0064] Process water 7%

[0065] Konjac or potato selected from plants is modified by nano-biotechnology ultra-microstructure, heavy metals are absorbed by chitosan, harmful substances are separated through synergistic copolymerization reaction, and temperature, time, process moisture and substance content are controlled.

[0066]1. Dissolve 32 grams of active protein in 1300 mL of water for dispersion, heat treatment at 100°C for 35 minutes, adjust the pH of the solution to 9 with 0.1N sodium hydroxide, add 55 grams of 30nm denatured glucomannan and 2.5 grams of sodium trimetaphosphate, and copolymerize React for 2.5 hours. Precipitate, wash, and dry to obtain the complex.

[0067] 2. Mix 36.5 grams of the compound with a particle size of 30 nm with 682.5 mL of water under stirring, c...

Embodiment 3

[0072] Raw material % by weight

[0073] Refined Starch C 35%

[0074] Active Protein J 35%

[0075] Pectin 8%

[0076] Propolis 7%

[0077] Chitosan 5.5%

[0078] Potassium Chloride 4.5%

[0079] Process water 5%

[0080] Konjac or potato selected from plants is modified by nano-biotechnology ultra-microstructure, heavy metals are absorbed by chitosan, harmful substances are separated through synergistic copolymerization reaction, and temperature, time, process moisture and substance content are controlled.

[0081] 1. Dissolve 35 grams of active protein in 1320 mL of water for dispersion, heat treatment at 100°C for 40 minutes, adjust the pH of the solution to 9 with 0.1N sodium hydroxide, add 65 grams of 30nm denatured glucomannan and 2.5 grams of sodium trimetaphosphate, and copolymerize React for 2.5 hours. Precipitate, wash, and dry to obtain the complex.

[0082] 2. Mix 36.3 grams of the compound with a particle size of 40 nm with 675 mL of water under stirring,...

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PUM

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Abstract

A nano-class hard hollow capsule is prepared from refined starch and active protein through mixing them with modifier, thermodecomposing reaction, washing, drying, superfine treating (including thermomodifying), regulating pH value, adding cross-linking agent, preparing sol, adding coagulant and coagulating aid, stirring, dipping resin by template, baking, pulling shell, cutting and finishing.

Description

technical field [0001] The present invention relates to a kind of nano-biological technology extracting active ingredients, separating harmful substances, and ultramicro-resulting capsule compound---nano-scale hollow capsule. Used in medicine, food, cosmetics or other film-like products. In particular, it relates to a hollow nano capsule, and also relates to a method for preparing the hollow capsule. The hard hollow capsule obtained by the invention is similar to the traditional gelatin hard hollow capsule, and its performance is better than that of the gelatin hollow capsule. Background technique [0002] At present, gelatin is the most preferred raw material for hard hollow capsules, because it has properties such as gelling, film-forming and surface activity. Gelatin hard hollow capsules have certain temperature and humidity requirements for capsule production, transportation and storage. Under the stress of unfavorable environmental factors, the capsule changes greatl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 武兴战
Owner 武兴战
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