Polyvinyl alcohol/sodium alginate medicine-loading hydrogel dressing having light-responsive bacteria resistance and preparation method of polyvinyl alcohol/sodium alginate medicine-loading hydrogel dressing

Abstract

The invention relates to polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing having light-responsive bacteria resistance and a preparation method of the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing, wherein a macromolecular medicine realizing fracturing under ultraviolet light is distributed inside the hydrogel dressing. The preparation method of the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing comprises the following steps: grafting micromolecule antibiotic, namely, levofloxacin to polyethylene glycol macromolecular chains with amino groups at two ends through molecules with ultraviolet light response property, thus obtaining the macromolecular medicine realizing fracturing under ultraviolet light; and carrying out repeated freezing and thawing on a mixed solution of polyvinyl alcohol solution, sodium alginate solution and the macromolecular medicine realizing fracturing under ultraviolet light, thus obtaining the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing having light-responsive bacteria resistance. The adopted raw materials have good biocompatibility, the obtained hydrogel dressing has certain mechanical property and has the ultraviolet-light-responsive antibacterial property, namely, the hydrogel dressing can realize controlled release of antibiotics under irradiation of 365nm ultraviolet light, and thus the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing is suitable for protecting and treating the wound surface.

Description

technical field

[0001] The invention relates to a hydrogel dressing and a preparation method thereof, in particular to a photoresponsive antibacterial polyvinyl alcohol / sodium alginate drug-loaded hydrogel dressing and a preparation method thereof. Background technique

[0002] As the largest organ of the human body, the skin is vulnerable to various damages due to long-term large-scale exposure. Wound repair is a complex and dynamic process involving the joint action of various cells and factors. The development of wound dressings has improved the process of wound repair. An ideal wound dressing can not only serve as a physical barrier to the wound to prevent further damage and contamination of the wound, but also provide a moist environment for the wound to accelerate wound healing. Commonly used dressings mainly include hydrogel type, foam type, film type and hydrocolloid type. Among them, hydrogel type dressings have achieved rapid development in recent years because of...

Examples

example 1

[0026] a) Synthesis of UV-cleavable macromolecular drugs

[0027] Take 0.3g (1mmol) HMNB dissolved in 4ml of methylpyrrolidone and heat it ultrasonically to make it fully dissolved, and pass through N 2 Purify for 10 minutes, add 0.41g (1.08mmol) HBTU, 0.146g (1.08mmol) HOBT, 0.25g (1.97mmol) DIEA, ultrasonically disperse, dissolve and stir for 5min, take 0.5g (0.1mmol) NH 2 -PEG5000-NH 2 Dissolve in 4ml of methylpyrrolidone, and add dropwise to the above solution, immediately vortex and heat the mixed solution until all the reagents are completely dissolved. React at room temperature overnight in the dark. After the reaction, the reaction solution was precipitated with glacial ether (the reaction solution was slowly added to 10 times the volume of glacial ether), centrifuged, and the precipitated product was washed with glacial ether again, and centrifuged twice. After vacuum drying, the obtained centrifuged product was redissolved in Centrifuge in deionized water to remov...

example 2

[0032] a) Synthesis of macromolecular drugs that can be broken by ultraviolet light Take 0.3g (1mmol) HMNB dissolved in 4ml of methylpyrrolidone and heat it so that it is fully dissolved by ultrasonic heating. 2 Purify for 10 minutes, add 0.41g (1.08mmol) HBTU, 0.146g (1.08mmol) HOBT, 0.25g (1.97mmol) DIEA, ultrasonically disperse, dissolve and stir for 5min, take 0.5g (0.1mmol) NH 2 -PEG5000-NH 2 Dissolve in 4ml of methylpyrrolidone and add dropwise to the above solution. Immediately vortex and heat the mixed solution until all reagents are completely dissolved. React at room temperature overnight in the dark. After the reaction, the reaction solution was precipitated with glacial ether (the reaction solution was slowly added to 10 times the volume of glacial ether), centrifuged, and the precipitated product was washed with glacial ether again, and centrifuged twice. After vacuum drying, the obtained centrifuged product was redissolved in Centrifuge in deionized water to re...

technical field

[0001] The invention relates to a hydrogel dressing and a preparation method thereof, in particular to a photoresponsive antibacterial polyvinyl alcohol / sodium alginate drug-loaded hydrogel dressing and a preparation method thereof. Background technique

[0002] As the largest organ of the human body, the skin is vulnerable to various damages due to long-term large-scale exposure. Wound repair is a complex and dynamic process involving the joint action of various cells and factors. The development of wound dressings has improved the process of wound repair. An ideal wound dressing can not only serve as a physical barrier to the wound to prevent further damage and contamination of the wound, but also provide a moist environment for the wound to accelerate wound healing. Commonly used dressings mainly include hydrogel type, foam type, film type and hydrocolloid type. Among them, hydrogel type dressings have achieved rapid development in recent years because of...

Examples

example 1

[0026] a) Synthesis of UV-cleavable macromolecular drugs

[0027] Take 0.3g (1mmol) HMNB dissolved in 4ml of methylpyrrolidone and heat it ultrasonically to make it fully dissolved, and pass through N 2 Purify for 10 minutes, add 0.41g (1.08mmol) HBTU, 0.146g (1.08mmol) HOBT, 0.25g (1.97mmol) DIEA, ultrasonically disperse, dissolve and stir for 5min, take 0.5g (0.1mmol) NH 2 -PEG5000-NH 2 Dissolve in 4ml of methylpyrrolidone, and add dropwise to the above solution, immediately vortex and heat the mixed solution until all the reagents are completely dissolved. React at room temperature overnight in the dark. After the reaction, the reaction solution was precipitated with glacial ether (the reaction solution was slowly added to 10 times the volume of glacial ether), centrifuged, and the precipitated product was washed with glacial ether again, and centrifuged twice. After vacuum drying, the obtained centrifuged product was redissolved in Centrifuge in deionized water to remov...

example 2

[0032] a) Synthesis of macromolecular drugs that can be broken by ultraviolet light Take 0.3g (1mmol) HMNB dissolved in 4ml of methylpyrrolidone and heat it so that it is fully dissolved by ultrasonic heating. 2 Purify for 10 minutes, add 0.41g (1.08mmol) HBTU, 0.146g (1.08mmol) HOBT, 0.25g (1.97mmol) DIEA, ultrasonically disperse, dissolve and stir for 5min, take 0.5g (0.1mmol) NH 2 -PEG5000-NH 2 Dissolve in 4ml of methylpyrrolidone and add dropwise to the above solution. Immediately vortex and heat the mixed solution until all reagents are completely dissolved. React at room temperature overnight in the dark. After the reaction, the reaction solution was precipitated with glacial ether (the reaction solution was slowly added to 10 times the volume of glacial ether), centrifuged, and the precipitated product was washed with glacial ether again, and centrifuged twice. After vacuum drying, the obtained centrifuged product was redissolved in Centrifuge in deionized water to re...

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