Preparation method of biodegradable medicine composite macromolecular scaffold material

A technology of composite polymers and scaffold materials, applied in medical science, medical containers, pharmaceutical packaging, etc., can solve the problems of inconvenient fiber pore formation, decrease in polymer molecular weight, and difficulty in obtaining it, so as to prevent restenosis of blood vessels and achieve good operation anti-thrombosis effect
CN1367023AInactive Publication Date: 2002-09-04TSINGHUA UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2002-09-04
Estimated Expiration
Not applicable · inactive patent
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Abstract

A preparation method of biodegradable medicine-compounded macromolecular scaffolding material includes the following steps: dissolving macromolecular polylactic acid, polycaprolactone and restenosis-resisting medicine in the solvent, pouring the prepared solution into a container for film-forming, making the said film into filament, dipping the said filament in the mixed solution prepared with L-lactic acid and diglycolide copolymer, solvent and restenosis-resisting medicine and drying in the air or freeze-drying, then soaking the said filament in anticoagulative solution, drying in the air, making filament wind round the mould, thermosetting and forming so as to obtain the invented product. The described solvent is chloroform, 1,4-dioxane and dimethyl sulfoxide, the restenosis-resisting medicine is taxol, taxadter, arotinoid ethylester, probucol, dectan and cilomosi, and the anticoagulative solution is prepared with carboxylated sulfurnic aid esterified chitin aqueos solution or heparin sodium aqueos solution and acetone through the process of mixing and solvation reaction.
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Description

technical field

[0001] The invention relates to a preparation method of a biodegradable drug composite polymer scaffold material, which belongs to the technical field of bioengineering. Background technique

[0002] Transcatheter interventional therapy is one of the most commonly used treatments for vascular obstructive diseases, especially percutaneous transluminal coronary angioplasty (PTCA) is a very effective treatment for coronary obstructive diseases. The metal stent currently used clinically is a kind of foreign body to the human body, which makes people have doubts about its long-term safety. Moreover, metal stents can also cause damage to the arterial wall, causing inflammation and restenosis.

[0003] Degradable polymer scaffolds have good biocompatibility, and can eventually degrade and disappear in the body, avoiding long-term effects on the human body. Polymer materials can conveniently carry sustained-release drugs through adsorption grafting and other means ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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