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Medicinal composition for treating angiocardiopathy

A composition and cardiovascular technology, applied in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as differences in the absorption rate and absorption amount of probucol

Inactive Publication Date: 2009-04-22
迈洋致达(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the rate and amount of absorption of probucol varies significantly between individual patients

Method used

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  • Medicinal composition for treating angiocardiopathy
  • Medicinal composition for treating angiocardiopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prescription (per 1000 tablets):

[0023] Fenofibrate 100g

[0024] Probucol 500g

[0025] Sodium carboxymethyl starch 50g

[0026] Corn starch 3000g

[0027] Magnesium Stearate 300g

[0028] Pass fenofibrate and probu through a 40-mesh sieve. Fully mix fenofibrate and probucol with cornstarch and carboxymethyl starch sodium according to the prescription amount, mix with magnesium stearate and compress into tablets to obtain the product.

Embodiment 2

[0030] Prescription (per 1000 tablets):

[0031] Fenofibrate 100g

[0032] Probucol 500g

[0033] Sodium carboxymethyl starch 50g

[0034] Lactose 1000g

[0035] Magnesium Stearate 200g

[0036] Pass fenofibrate and probu through a 40-mesh sieve. Thoroughly mix fenofibrate, probucol, lactose and carboxymethyl starch sodium according to the prescription amount, mix with magnesium stearate and compress into tablets to obtain the product.

Embodiment 3

[0038] Prescription (per 1000 capsules):

[0039] Fenofibrate 100g

[0040] Probucol 500g

[0041] Sodium hydroxymethyl starch 40g

[0042] Hydroxypropyl methylcellulose solution (1%) 50g

[0043] Microcrystalline Cellulose 800g

[0044] Magnesium Stearate 200g

[0045] Pass fenofibrate and probu through an 80-mesh sieve. After fully mixing fenofibrate, probucol, microcrystalline cellulose, and sodium starch glycolate according to the prescription amount, prepare soft materials with the prescription amount of hydroxypropyl methylcellulose solution, granulate, dry, and dry for 18 Mesh sieve for granulation, fully mix with the prescribed amount of magnesium stearate, and then pack into capsules.

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Abstract

The invention relates to a medicament composition for treating cardiovascular diseases. The composition contains Fenofibrate, Probucol and pharmaceutically acceptable carrier or excipient with effective dose for treating.

Description

technical field [0001] The invention relates to the field of drug therapy, and more specifically relates to a drug composition for treating cardiovascular diseases. Background technique [0002] In my country, cardiovascular and cerebrovascular diseases are the number one cause of death. With the improvement of living standards, people's diet structure changes, activity decreases, cholesterol intake and body mass index increase, all of which are risk factors for cardiovascular and cerebrovascular diseases. The incidence of cardiovascular and cerebrovascular diseases in my country has been increasing year by year in recent years. [0003] Among cardiovascular diseases hypertension, myocardial infarction and angina pectoris are among the most common causes of death in both men and women. In addition to coronary artery disease, cerebrovascular disease and stroke are the most common causes of death. In addition, cardiovascular disease causes significant disability from stroke...

Claims

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Application Information

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IPC IPC(8): A61K31/215A61K31/10A61P9/00
Inventor 颜文革漆新国阚迎昕
Owner 迈洋致达(北京)科技有限公司
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