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A composition and blood lipid-lowering technology, applied in the new field of medicine
Inactive Publication Date: 2010-07-07
BEIJING HOPE HUGE PHARM SCI
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The average plasma half-life of atorvastatin is about 14 hours, but due to the influence of
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[0038] Pass probucol, atorvastatin, xylitol, mannitol and other raw and auxiliary materials through a 50-mesh sieve respectively, mix them uniformly by using an equal-volume increasing method, add 3% PVPk-30 ethanol solution, and make a soft material with a 24-mesh sieve Granules, dried, granulated with a 20-mesh sieve, dried, added other flavoring agents, sweeteners, and glidants, mixed evenly, compressed into tablets, and obtained.
[0043] Pass probucol, atorvastatin and other raw materials through 80-mesh sieve, mix well, add 75% ethanol solution, make soft material, granulate with 16-mesh sieve, dry, granulate with 20-mesh sieve, add other flavoring agents Sweet orange essence, sweetener aspartame, and disintegrant PPVP are mixed evenly, and pressed into tablets to obtain the product.
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Abstract
The invention discloses an officinal composition for lowering blood fat. Active ingredients are atorvastatin and probucol. The invention provides a better fat regulating drug for patients clinically suffering from severe lipid metabolism disorders and especially has favorable synergistic effect on patients at high liver function damaging risk level by drug combination; two kinds of drugs complement advantages so as to obviously lower the possibility of side effect occurrence because of increased amount of atorvastatin. The officinal composition for lowering blood fat is prepared from active ingredients and pharmaceutically acceptable supplementary materials, but is not limited in preparations, such as tablets, dispersible tablets, sustained release tablets and the like.
Description
technical field [0001] The invention belongs to the field of new medicine technology and relates to a blood lipid-lowering medicinal composition. Background technique [0002] Hypertension and hyperlipidemia have become a common disease and frequently-occurring disease. [0003] Atorvastatin is a statin blood lipid regulating drug and is an HMG-CoA reductase inhibitor. It itself is inactive, and the hydrolyzate after oral absorption competitively inhibits the rate-limiting enzyme hydroxymethylglutaryl-CoA reductase in the process of cholesterol synthesis in vivo, reducing the synthesis of cholesterol and increasing the synthesis of low-density lipoprotein receptors , the main site of action is in the liver. As a result, blood cholesterol and low-density lipoprotein cholesterol levels are reduced, serum triglyceride levels are moderately reduced, and blood high-density lipoprotein levels are increased. Thus, it has an effect on the prevention and treatment of atherosclerosi...
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