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The application discloses a compound based on a PROTAC strategy and a preparation method, a pharmaceutical composition and application thereof, discloses a compound with AR / AR-V7 protein degradation activity and a preparation method, a pharmaceutical composition and application thereof. The structure of the compound is as shown in the formula I. The compound can effectively degrade AR / AR-V7 proteins in vivo and in vitro, has a significant antitumor effect, has no obvious toxic side effects, and can be used for treating castration-resistant prostate cancer. The preparation method of the compound is simple and easy to operate, and is beneficial to structural expansion.