The invention belongs to the field of
veterinary drugs and discloses a method for preparing a
florfenicol-beta-
cyclodextrin inclusion compound through ultrasonic-centrifugal
drying. The method comprises the following steps:
florfenicol and beta-
cyclodextrin are taken, water is added, the solution is heated and dissolved at the constant temperature of 90-110 DEG C, and a feed liquid A is obtained,wherein the
mass ratio of
florfenicol to beta-
cyclodextrin is 1:(2-9), and the ratio of the
mass of the water to the total
mass of florfenicol and beta-cyclodextrin is (2-4):1; the feed liquid A is ultrasonically treated with the ultrasonic frequency being 40-60 HZ, and a feed liquid B is obtained; the feed liquid B is centrifugally dried, and a dried product is the florfenicol-beta-cyclodextrin
inclusion compound; in terms of centrifugal
drying parameters, the rotating rate of a centrifugal pan is 20,000-24,000 rpm, the air intake temperature is 140-160 DEG C, and the feeding amount is 200-400 kg / h. The water
solubility of the florfenicol-beta-cyclodextrin
inclusion compound is as high as 5,000 ppm at the
water temperature of 25 DEG C, so that the water
solubility of the florfenicol is improved substantially; the yield of the florfenicol-beta-cyclodextrin inclusion compound is 98% or higher, and the inclusion rate is 95% or higher.