Preparation method for antibacterial hemostatic microspheres based on cellulose

A carboxymethyl cellulose and cellulose technology, applied in the field of functional polymer materials, can solve the problems of poor biocompatibility, hemostatic microspheres do not have antibacterial properties, etc., achieve good hemostasis performance, improve cross-linking effect and stability , the effect of promoting hydrophobic association

Active Publication Date: 2017-02-22
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that traditional cellulose-based hemostatic microspheres do not have antibacterial properties and have poor biocompatibility, and provide a preparation method for a class of cellulose-based antibacterial hemostatic microspheres

Method used

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  • Preparation method for antibacterial hemostatic microspheres based on cellulose

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Embodiment 1

[0022] Example 1: 0.5 g of carboxymethyl cellulose grafted polylactic acid was dissolved in 99.5 g of ethanol to obtain solution A. Dissolve 0.5g of sodium alginate in 49.5g of water to obtain solution B, mix the above solutions A and B, add 0.075g of emulsifier Tween-80, and 1.5g of tea tree oil, heat and stir at 50°C for 3h . After the microspheres were centrifuged, washed with DMSO, filtered and dried, the microsphere product was obtained.

Embodiment 2

[0023] Example 2: 0.4 g of carboxymethyl cellulose grafted polylactic acid was dissolved in 79.6 g of ethanol to obtain solution A. Dissolve 0.7g of potassium alginate in 69.3g of water to obtain solution B, mix the above solutions A and B, add 0.075g of emulsifier Tween-80, and 1.5g of tea tree oil, heat and stir at 50°C for 3h . After the microspheres were centrifuged, washed with DMSO, filtered and dried, the microsphere product was obtained.

Embodiment 3

[0024] Example 3: 2 g of carboxymethyl cellulose grafted poly(tert-butyl acrylate) was dissolved in 98 g of acetone to obtain solution A. Dissolve 2g of sodium alginate in 18g of water to obtain solution B, mix the above solutions A and B, add 0.12g of emulsifier AEO-9, and 1.8g of tea tree oil, heat and stir at 70°C for 1h. After the microspheres were centrifuged, washed with DMAc, filtered and dried, the microsphere product was obtained.

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Abstract

The invention relates to a preparation method for antibacterial hemostatic microspheres based on cellulose, and belongs to the field of functional polymer materials. The preparation method for the antibacterial hemostatic microspheres comprises the steps: firstly, dissolving amphiphilic cellulose derivatives in an organic solvent, dissolving alginate in water, and mixing the two solutions; then adding an oil-in-water type emulsifier and tea tree oil into the mixed solution, and then carrying out heating and stirring reaction for 1-10 h under a condition of the temperature of 30-80 DEG C; and finally, separating microspheres by centrifugation, washing with a washing auxiliary agent, and filtering and drying to obtain the microsphere product. The method avoids toxic effects generated from microsphere crosslinking with a chemical crosslinking agent, and the obtained microspheres have certain hydrophilicity and have good hemostatic and antibacterial effects.

Description

technical field [0001] The invention relates to a preparation method of a class of cellulose-based antibacterial and hemostatic microspheres, belonging to the field of functional polymer materials. Background technique [0002] In various emergencies and first aid, rapid and effective hemostasis on the bleeding wound of the wounded is of great significance for improving the first aid effect and survival rate. Therefore, the development of rapid hemostatic materials for large-area deep jet bleeding has important clinical value. [0003] Cellulose, a natural polymer material, has good biocompatibility and biodegradability, and there have been many reports on cellulose-based hemostatic microspheres. However, although the existing microsphere materials have a good hemostatic effect, they do not have antibacterial properties. After hemostasis, due to the strong hydrophilic property of the microspheres, it is easy to cause bacterial growth and infection in the wound. In addition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0005A61L24/0015A61L24/08A61L2300/30A61L2300/404A61L2400/04C08L1/286C08L87/005C08L51/02C08L5/04
Inventor 陈煜闫晓婷李鹏赵健付浩熹
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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