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Peppermint essential oil and mixed cyclodextrin inclusion compound and preparation method thereof

A technology of mixing cyclodextrin and peppermint essential oil, which is applied in the field of medicine, can solve the problems of poor water solubility, unsustainable aroma, influence on menthol processing preparations and inconvenient storage, etc., achieve high inclusion rate, improve inclusion rate, and improve production conditions easy to control effects

Inactive Publication Date: 2013-09-04
江苏丰园生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, menthol has poor water solubility and will sublimate in the air, making menthol transparent and pleasant mint characteristic aroma not lasting
These disadvantages have seriously affected the inconvenience of menthol in preparation and storage.

Method used

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  • Peppermint essential oil and mixed cyclodextrin inclusion compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Determination of the optimal ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin

[0018] Six different ratios of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin were selected. After many experiments, the mixed cyclodextrins containing different proportions were packaged at the same temperature and inclusion time. According to the level of inclusion rate, select the best ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin. The data in Table 1 are obtained through experiments:

[0019] Table 1 Determination table of optimal ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin

[0020]

[0021] Cyclodextrin cyclodextrin CD for short.

[0022] From the experimental results, it can be seen that when the mixed cyclodextrin is composed of 2-6 parts of α-cyclodextrin, 1-3 parts of β-cyclodextrin and 1-2 parts of γ-cyclodextrin by weight, the package of peppermint essential oil The inclusion rate was higher. When the mixed cyclodextrin con...

Embodiment 2

[0024] 6 parts of mixed cyclodextrin (the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 4:2:1), 80 parts of water, heated to 65°C to make mixed cyclodextrin Saturated aqueous solution, cooled to 45°C, add 1 part of peppermint essential oil drop by drop, use a shearing machine to carry out clathrate under stirring at 5000r / min, keep the temperature of the system between 35-45°C, shear the clathrate for 60 minutes After passing the microscopic examination, it was stirred for 60-80 minutes and cooled down to room temperature, and the peppermint essential oil inclusion compound solution was spray-dried to obtain the finished peppermint essential oil and mixed cyclodextrin inclusion compound, and the inclusion rate of the peppermint essential oil was 93.4%.

Embodiment 3

[0026] 7 parts of mixed cyclodextrin (the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 4:2:1), 85 parts of water, heated to 65°C to make mixed cyclodextrin Saturated aqueous solution, cooled to 45°C, add 1 part of peppermint essential oil drop by drop, and use a shearing machine to carry out clathrate under stirring at 5000r / min. After passing the microscopic examination, it was stirred for 60-80 minutes and cooled down to room temperature, and the peppermint essential oil inclusion compound solution was spray-dried to obtain the finished peppermint essential oil and mixed cyclodextrin inclusion compound, and the inclusion rate of the peppermint essential oil was 95.4%.

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Abstract

The invention belongs to the technical field of medicines and in particular relates to a peppermint essential oil and mixed cyclodextrin inclusion compound and a preparation method thereof. According to the technical scheme, the mixture of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and the peppermint essential oil are included in water, so that the inclusion rate is improved, the solubility and stability are improved, and an organic solvent is avoided in the production process.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an inclusion compound of peppermint essential oil and mixed cyclodextrin and a preparation method thereof. Background technique [0002] Peppermint essential oil is the extract of fresh peppermint, a large medicinal material of the Labiatae family. Peppermint is a traditional Chinese medicine, pungent in taste and cool in nature. It has the functions of dispelling wind, cooling, and detoxifying. In addition, peppermint essential oil is also widely used in various industries such as food processing, spices, beverages, pharmaceutical industry, daily chemical industry, cosmetics, and light chemical industry. However, menthol has poor water solubility and will sublimate in the air, making the pleasant mint characteristic aroma of menthol not lasting. These disadvantages have seriously affected the inconvenience of menthol in preparation and storage. [0003] Cyclodextrin is the p...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K47/40A23L1/221A23L2/52A61K8/97A61K8/73A61P27/02A61P11/00A61P11/04A61P17/04A23L27/10
Inventor 徐文峰
Owner 江苏丰园生物技术有限公司
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