Coenzyme Q10 inclusion compound and preparation technology thereof

Abstract

The invention relates to a coenzyme Q10 inclusion compound and a preparation technology thereof, and belongs to the fields of food, medicines and health care products. The coenzyme Q10 inclusion compound is prepared from the following components in parts by weight, 0.5-8 parts of coenzyme Q10, 1-10 parts of cyclodextrin and 50-600 parts of hydrophilic diluting agent. The coenzyme Q10 inclusion compound and the preparation technology thereof have the advantages that a reasonable dosage of the hydrophilic diluting agent is used for making non-polar coenzyme Q10 molecules be repelled by the hydrophilic diluting agent and remain in cavities of the cyclodextrin better, the proportion of the coenzyme Q10 molecules which are detached from the cyclodextrin in an inclusion compound drying process is reduced, the inclusion rate of the coenzyme Q10-cyclodextrin inclusion compound is improved, and the stability of the coenzyme Q10 in the solid state is further improved.

Description

technical field [0001] The invention relates to a coenzyme Q10 inclusion compound and a preparation process thereof, belonging to the fields of food, medicine and health care products, in particular to a water-soluble inclusion compound containing coenzyme Q10 and a preparation process thereof. Background technique [0002] Coenzyme Q10 exists in the inner membrane of mitochondria of many advanced animals and plants. It participates in energy production and activation in human cells. It is a natural antioxidant and cell metabolism starter produced by cells itself. It can protect and restore the integrity and stability of biofilm structures. The effect of membrane potential is the body's non-specific immune enhancer. As an effective antioxidant and free radical scavenger, coenzyme Q10 can inhibit the modification of free radicals on immune cell receptors and microtubule systems related to cell differentiation activity, strengthen the immune system, and delay aging. Coenzyme ...

AI Technical Summary

Problems solved by technology

[0003] The acquisition of coenzyme Q10 can come from food, but sometimes the amount obtained from food cannot meet the needs of the human body, so you can eat coenzyme Q10 dietary supplement products

Coenzyme Q10 is a fat-soluble quinone compound, insoluble in water, unstable to light, heat, and water, and has low bioavailability after oral administration. compound technology

The patent publication number is CN101053556A, and the invention patent named "A water-soluble coenzyme Q10 hydroxypropyl-β-cyclodextrin inclusion compound and its preparation method" introduces the use of hydroxypropyl-β-cyclodextrin as cyclodextrin Coenzyme Q10 is included and dried to prepare a coenzyme Q10 inclusion compound, but the weight ratio of hydroxypropyl-β-cyclodextrin to coenzyme Q10 in the above invention is large

Existing inclusion techniques for the preparation of coenzyme Q10 inclusion complexes all have the disadvantages of a large amount of cyclodextrin and a small amount of effective drugs

In addition, the existing inclusion technology is to add coenzyme Q10 to the cyclodextrin aqueous solution, the non-polar coenzyme Q10 molecules repel the polar water molecules, so the coenzyme Q10 molecules can stably exist in the cyclodextrin However, in the process of drying the clathrate solution, the water molecules are greatly reduced, and the repulsion force of coenzyme Q10 is also greatly reduced, which destroys the stable environment in which coenzyme Q10 exists in the cyclodextrin cavity, and a part of coenzyme Q10 molecules Detaching from the cyclodextrin cavity, not only coenzyme Q10 molecules combine with each other to form a precipitate, but also the inclusion rate of coenzyme Q10-cyclodextrin inclusion complex is low

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