Coenzyme Q10 inclusion compound and preparation technology thereof

A clathrate and coenzyme technology, which is applied in food science, drug combination, medical preparations of non-active ingredients, etc., can solve the problems of low bioavailability, large weight ratio, large amount of cyclodextrin, etc. Combine rate, improve stability, reduce ratio effect

Active Publication Date: 2018-11-02
北京素维生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The acquisition of coenzyme Q10 can come from food, but sometimes the amount obtained from food cannot meet the needs of the human body, so you can eat coenzyme Q10 dietary supplement products
Coenzyme Q10 is a fat-soluble quinone compound, insoluble in water, unstable to light, heat, and water, and has low bioavailability after oral administration. compound technology
The patent publication number is CN101053556A, and the invention patent named "A water-soluble coenzyme Q10 hydroxypropyl-β-cyclodextrin inclusion compound and its preparation method" introduces the use of hydroxypropyl-β-cyclodextrin as cyclodextrin Coenzyme Q10 is included and dried to prepare a coenzyme Q10 inclusion compound, but the weight ratio of hydroxypropyl-β-cyclodextrin to coenzyme Q10 in the above invention is large
Existing inclusion techniques for the preparation of coenz

Method used

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  • Coenzyme Q10 inclusion compound and preparation technology thereof
  • Coenzyme Q10 inclusion compound and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] Example 1

[0038] Formula: 0.5g coenzyme Q10; 3g hydroxypropyl-β-cyclodextrin; 50g mannitol

[0039] Process: Add coenzyme Q10 to saturated hydroxypropyl-β-cyclodextrin aqueous solution, stir with an electric stirrer at 50°C for 30 minutes to accelerate the dissolution of coenzyme Q10 to obtain the inclusion compound solution, and then add the inclusion compound Mannitol is added to the solution, washed and dried to obtain inclusion compound powder. The clathrate powder is placed in a tablet press and compressed into tablets.

Example Embodiment

[0040] Example 2

[0041] Formula: 1g coenzyme Q10; 8g β-cyclodextrin; 100g starch

[0042] Process: Add coenzyme Q10 to the β-cyclodextrin aqueous solution, stir well to prepare a solution of the inclusion compound encapsulated by coenzyme Q10, then add starch to the inclusion compound solution, and dry the solution under spray conditions. Inclusion compound powder. The inclusion compound powder is added to a granulator to obtain granules, which are made into granules.

Example Embodiment

[0043] Example 3

[0044] Formula: 8g coenzyme Q10; 5g sulfobutyl ether-β-cyclodextrin; 550g sorbitol

[0045] Process: Dissolve coenzyme Q10 and sulfobutyl ether-β-cyclodextrin in water, stir to dissolve to obtain an inclusion compound solution, then add sorbitol to the inclusion compound solution, and sublimate the water by cooling and reducing pressure. Prepare dry clathrate powder. The clathrate powder is pulverized again with a grinder to make a powder.

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Abstract

The invention relates to a coenzyme Q10 inclusion compound and a preparation technology thereof, and belongs to the fields of food, medicines and health care products. The coenzyme Q10 inclusion compound is prepared from the following components in parts by weight, 0.5-8 parts of coenzyme Q10, 1-10 parts of cyclodextrin and 50-600 parts of hydrophilic diluting agent. The coenzyme Q10 inclusion compound and the preparation technology thereof have the advantages that a reasonable dosage of the hydrophilic diluting agent is used for making non-polar coenzyme Q10 molecules be repelled by the hydrophilic diluting agent and remain in cavities of the cyclodextrin better, the proportion of the coenzyme Q10 molecules which are detached from the cyclodextrin in an inclusion compound drying process is reduced, the inclusion rate of the coenzyme Q10-cyclodextrin inclusion compound is improved, and the stability of the coenzyme Q10 in the solid state is further improved.

Description

technical field [0001] The invention relates to a coenzyme Q10 inclusion compound and a preparation process thereof, belonging to the fields of food, medicine and health care products, in particular to a water-soluble inclusion compound containing coenzyme Q10 and a preparation process thereof. Background technique [0002] Coenzyme Q10 exists in the inner membrane of mitochondria of many advanced animals and plants. It participates in energy production and activation in human cells. It is a natural antioxidant and cell metabolism starter produced by cells itself. It can protect and restore the integrity and stability of biofilm structures. The effect of membrane potential is the body's non-specific immune enhancer. As an effective antioxidant and free radical scavenger, coenzyme Q10 can inhibit the modification of free radicals on immune cell receptors and microtubule systems related to cell differentiation activity, strengthen the immune system, and delay aging. Coenzyme ...

Claims

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Application Information

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IPC IPC(8): A23L33/00A61K31/122A61K47/69A61P39/06A61P37/04A61P9/00A61P35/00A61P9/12
CPCA61K47/69A61P9/00A61P9/12A61P35/00A61P37/04A61P39/06A23L33/00A61K31/122A23V2002/00A23V2200/326
Inventor 许伯慧陈曼佘佐彦
Owner 北京素维生物科技有限公司
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