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Preparation method of aromatic decocting-free traditional Chinese medicine agent

An aromatic and decoction-free technology, which is applied in the direction of pharmaceutical formulas, non-central analgesics, and medical preparations containing active ingredients, can solve the problem of destroying heat-sensitive active ingredients of medicinal materials, inevitable organic solvent residues, and loss of volatile oil components, etc. problems, to achieve good inclusion effect, increase dissolution rate and dissolution times, and maintain physiological activity

Inactive Publication Date: 2015-12-23
HENAN XINGZHI PATENT SERVICE CO LTD
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Problems solved by technology

The traditional volatile oil extraction methods are mainly steam distillation and organic solvent extraction. These traditional extraction methods have unavoidable shortcomings, such as long extraction time, easy deterioration of unstable components due to humidity and heat, loss of low boiling point volatile oil components, and unavoidable Residue of organic solvents, thus affecting the quality of volatile oil
Traditional Chinese medicine preparations containing volatile oils are used to extract the remaining active ingredients after extracting the volatile oils. The extraction time is long, the extraction efficiency is not high, and the heat-sensitive active ingredients in the medicinal materials will be destroyed.

Method used

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preparation example Construction

[0029] A preparation method of aromatic traditional Chinese medicine decoction, comprising the following steps:

[0030] 1) Pick up the aromatic Chinese medicinal materials and remove impurities, and dry them below 60°C;

[0031] 2) Coarsely pulverize the dried aromatic Chinese medicinal materials and pass through a 20-40 mesh sieve to obtain coarse powder of Chinese medicinal materials;

[0032] 3) Put the coarse powder of Chinese medicinal materials obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, and then enters the separation tank for separation to obtain extracts and medicinal residues;

[0033] 4) Mix the extract obtained in step 3) with 5-10 times the weight of β-cyclodextrin and 5-15 times the weight of purified water, and then perform ultrasonic inclusion treatment to obtain the inclusion compound;

[0034] 5) Add 10 to 15 times the volume of water to the medicinal residue obtained in step 3), soak for 8 to 12 hours, an...

Embodiment 1

[0046] Taking peppermint as an example, the preparation method of Chinese medicine-free decoction comprises the following steps:

[0047] 1) Pick up the mint to remove impurities, and dry it in vacuum at 60°C;

[0048] 2) Coarsely pulverize the dried mint and pass through a 20-mesh sieve to obtain mint coarse powder;

[0049] 3) Put the mint coarse powder obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, the extraction temperature is 35°C, the pressure is 25MPa, CO 2 The flow rate is 5L / min, the extraction time is 2h, and then it enters the separation tank for separation to obtain the extract and medicinal residues;

[0050] 4) Mix the extract obtained in step 3) with 5 times the weight of β-cyclodextrin and 5 times the amount of pure water, and then perform ultrasonic inclusion treatment. The ultrasonic frequency is 20kHz, the power is 300W, and the time is 50min to obtain the inclusion compound;

[0051] 5) Add 10 times the vo...

Embodiment 2

[0055] Taking Huoxiang as an example, the preparation method of Chinese medicine-free decoction comprises the following steps:

[0056] 1) Pick up Huoxiang and remove impurities, then vacuum dry at 55°C;

[0057] 2) Coarsely pulverize the dried Huoxiang, and pass through a 25-mesh sieve to obtain Huoxiang coarse powder;

[0058] 3) Put the Huoxiang coarse powder obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, the extraction temperature is 40°C, the pressure is 28MPa, CO 2 The flow rate is 8L / min, the extraction time is 2.5h, and then it enters the separation tank for separation to obtain the extract and dregs;

[0059] 4) Mix the extract obtained in step 3) with 6 times its weight of β-cyclodextrin and 7 times its weight of pure water, and then perform ultrasonic inclusion treatment. The ultrasonic frequency is 22kHz, the power is 350W, and the time is 55min to obtain the inclusion compound;

[0060] 5) Add 12 times the volume...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation and particularly relates to a preparation method of an aromatic decocting-free traditional Chinese medicine agent. According to the preparation method, effective ingredients of volatile oil contained in aromatic traditional Chinese medicines are extracted with a supercritical CO2 extraction technology, extraction is performed with an ultrasonic-microwave synergic extraction technology, an extraction solution is filtered through a microfiltration technology, filtrate is concentrated and mixed with the volatile oil after inclusion, the mixture is dried and smashed, and the aromatic decocting-free traditional Chinese medicine agent is prepared from extract fine powder. The problems that the utilization rate of raw materials is low, effective ingredients of the volatile oil are not completely extracted and are severely damaged, the extraction efficiency is low and the like during extraction of traditional Chinese medicinal materials with a conventional method are solved; the whole technological process is simple to control, green and environment-friendly, the technological steps have synergistic interaction, accordingly, the extraction efficiency of the preparation method is higher, the effective ingredients are effectively protected, and the utilization rate of the aromatic traditional Chinese medicinal materials is increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a preparation method of aromatic traditional Chinese medicine free decoction. Background technique [0002] Traditional Chinese medicine is a unique medicine of traditional Chinese medicine, with a long history and rich resources. The ingredients of traditional Chinese medicine are complex and diverse. If the appropriate extraction, concentration, sterilization process and scientific and strict process operation parameters are not selected during the preparation of traditional Chinese medicine preparations, the active ingredients will be incompletely extracted or even destroyed, thereby affecting the efficacy of the medicine. Therefore, on the basis of inheriting and developing the advantages and characteristics of Chinese medicine in my country, it is imperative to reform the traditional Chinese medicine preparation process and develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K36/534A61K36/532A61K36/60A61K36/71A61K36/9064A61K36/725A61P11/00A61P29/00A61P1/14
Inventor 何敏
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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