Resveratrol-sulfobutyl ether-beta-cyclodextrin inclusion compound and preparing method thereof
A technology of cyclodextrin inclusion compound and resveratrol, which is applied in the direction of active ingredients of hydroxyl compounds, drug combinations, pharmaceutical formulations, etc., can solve the problem of resveratrol’s instability to light and heat, insignificant increase in water solubility, Problems such as low bioavailability, to achieve the effect of improving water solubility and stability, satisfactory inclusion rate, and low adverse reactions
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[0035] 1. Determination method of inclusion rate
[0036] 1.1 Chromatographic conditions
[0037] Chromatographic column: Agilent Eclipse XDB-C18 column (4.6mm×250mm, 5um); mobile phase: methanol-water (55:45); flow rate: 1.0mL / min; column temperature: 30°C; injection volume: 10μL; detection Wavelength: 307nm.
[0038] 1.2 Standard curve
[0039] Precisely weigh 10 mg of the resveratrol reference substance, dilute it to a 10 mL brown volumetric flask with methanol, and prepare a stock solution with a concentration of 1 mg / mL; draw up 20, 30, 40, 50, 60 and 70 μL of the stock solution precisely, and use Dilute methanol to 10mL and shake well. Filter with a 0.45um microporous membrane. Draw 10 μL into the liquid chromatograph respectively. Take the chromatographic peak area A as the ordinate, and the resveratrol concentration C as the abscissa to draw a standard curve to obtain the regression equation A=85086C+8933.6, R 2 =09993, n=6. It can be seen that the resveratrol c...
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