Tanshinone inclusion fluid as well as preparation method and application thereof

A technology of tanshinone and inclusion compound, which is applied in the field of tanshinone inclusion liquid and its preparation, can solve the problem of low solubility of tanshinone, and achieve the effects of good solubilization effect, stable quality and high inclusion rate

Inactive Publication Date: 2014-09-10
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to aim at the defect of low solubility of tanshinone in the above-mentioned prior art, and to provide a tanshinone package which utilizes cyclodextrin inclusion method to improve the solubility of tanshinone, increase the drug release rate, and improve its bioavailability so as to increase the curative effect. Mixture

Method used

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  • Tanshinone inclusion fluid as well as preparation method and application thereof
  • Tanshinone inclusion fluid as well as preparation method and application thereof
  • Tanshinone inclusion fluid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Preparation process of tanshinone breast injection:

[0026] 1.1 Test material:

[0027] 1.1.1 Drugs and reagents:

[0028] Tanshinone ⅡA reference substance (batch number 110766-200619) and cryptotanshinone reference substance (batch number 110852-200806) were purchased from China National Institutes for Food and Drug Control;

[0029] Tanshinone API powder (41.7% tanshinone content, 11.57% tanshinone IIA content, 3.16% cryptotanshinone content) was extracted by the laboratory of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences;

[0030] R-β-cyclodextrin, purchased from Shandong Zibo Qianhui Biotechnology Co., Ltd., content ≥ 98%;

[0031] Tanshinone perfusion solution, produced by Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences (batch numbers 20130722, 20130725, 20130728);

[0032] Ethyl acetate is analytically pure, petroleum ether (60-90°C), methanol ...

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Abstract

The invention discloses a tanshinone inclusion fluid. The host molecule of the tanshinone inclusion fluid is beta-cyclodextrin, and the guest molecule of the tanshinone inclusion fluid is tanshinone. The invention also provides a preparation method of the tanshinone inclusion fluid and an application of the tanshinone inclusion fluid in preparing a cow breast injection agent. The tanshinone inclusion fluid disclosed by the invention has the beneficial effects as follows: a tanshinone beta-cyclodextrin inclusion compound solution is prepared, and preparation process parameters of the tanshinone beta-cyclodextrin inclusion compound solution are optimized; a tanshinone cyclodextrin inclusion solution with minimum cyclodextrin dosage, highest tanshinone inclusion rate, relatively good solubilization effect and relatively stable quality can be obtained by virtue of investigation of physical and chemical properties of tanshinone and single-factor experiment and orthogonal experimental designs by focusing on the studies on each process parameter which influences the inclusion effects of the inclusion solution.

Description

[0001] Technical field [0002] The present invention involves the pharmaceutical field, which specifically involves a tannosterone packaging solution and its preparation methods and applications. Background technique [0003] Dairy breasts are infectious diseases that are very harmful to the dairy breeding industry. They can be divided into clinical acute mastitis, clinical sub -acute mastitis and hidden mastitis. Different types of breastitis are adapted to different therapeutic drugs and schemes.EssenceClinical acute and sub -acute breastitis, easy diagnosis, acute onset, obvious symptoms, and treatment effects often faster and obvious; hidden breastitis obviously visible clinical symptoms without diagnosis and long course of treatment, and poor treatment effects.The disease is prone to deterioration and cannot be cured for a long time. It is difficult to cure thoroughly. [0004] For various types of dairy breastitis, the drugs developed in China in recent decades have emerge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/58A61P15/14
Inventor 梁剑平郭文柱卢超强哲尚若锋王学红陶蕾刘宇郝宝成赵凤舞郭志廷贾忠
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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