Preparation method of rose essence beta-cyclodextrin polymer microsphere inclusion compound

A technology of cyclodextrin polymer and rose essence, which is applied in the preparation of microspheres, the formulation of perfume preparations, microcapsule preparations, etc., can solve the problem of low inclusion rate between β-CD and guest, poor stability and mechanical strength and other problems, to achieve the effects of promoting inclusion, increasing inclusion rate, and good slow-release effect

Inactive Publication Date: 2012-10-03
SHANGLUO UNIV
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Problems solved by technology

However, the inclusion rate of natural β-CD and the guest is not high, and the stability and mechanical strength are not good.

Method used

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Experimental program
Comparison scheme
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Embodiment Construction

[0016] The preparation process of the present invention is as follows:

[0017] 1) Dissolve 6g of β-CD in 10mL of 40% NaOH solution, add 7~8g of epichlorohydrin dropwise within 20min at 30~35℃ for crosslinking reaction for 1.5h;

[0018] 2) After the cross-linking reaction is completed, add 60g of 200 emulsifier containing 1.2g under high-speed stirring # After the kerosene is stirred evenly, reduce the stirring speed to 800r / min, and raise the temperature to 70°C for reaction;

[0019] Described emulsifier is the mixture that Span80 and Tween20 are made by the mass ratio of 3:1;

[0020] 3) Stand still after the reaction, separate the upper oil phase, filter the microsphere product, and fully wash to remove various impurities, dry it in a vacuum fume hood, and finally dry it in a vacuum oven at 60°C until constant Weight, that is, β-cyclodextrin polymer microspheres;

[0021] 4) Dissolve 1g of β-cyclodextrin polymer microspheres in 20mL of water to obtain a saturated solut...

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Abstract

A preparation method of a rose essence beta-cyclodextrin polymer microsphere inclusion compound comprises the following steps: preparing a beta-cyclodextrin polymer microsphere by an inverse emulsion polymerization method; dissolving rose essential oil in a small amount of anhydrous ethanol; including the solution with the beta-cyclodextrin polymer microsphere by a saturated aqueous solution method; and after completion of inclusion, eluting and performing vacuum decompressed drying to obtain an inclusion product. The preparation method of the rose essence beta-cyclodextrin polymer microsphere inclusion compound takes the beta-CD (cyclodextrin) as a matrix which is crosslinked by epichlorohydrin, and uses the beta-CD microsphere which is synthesized by the inverse emulsion polymerization method, so that not only the original cavity structure and the slow-release and controlled-release and identification capabilities of the beta-CD are kept, but also the hydrophobicity of a beta-CD cavity is improved, the inclusion is promoted and the inclusion rate is improved; and due to intermolecular synergistic inclusion after beta-cyclodextrin polymerization, so that rose essence and a substance with similar structure and solubility to the rose essence can be firmly clamped, thus playing a relatively good slow-release effect.

Description

technical field [0001] The invention relates to a preparation method of a polymer microsphere inclusion compound, in particular to a preparation method of a rose essence β-cyclodextrin polymer microsphere inclusion compound used in cosmetics and pharmaceutical industries. Background technique [0002] Rose is a plant of the genus Rosa in the family Rosaceae. It has gorgeous flowers, strong and pure aroma, and high oil content. It is an important raw material for spices, food industry and medicine. Its main components are citronellol, geraniol, nerol, eugenol and aromatic Camphor, etc. [0003] The extraction of rose essence mainly includes three methods: steam distillation, active C adsorption and organic solvent extraction, among which the organic solvent extraction method is the best. If rose essence is extracted from rose petals by steam distillation, about 4,000 kilograms of rose petals can only extract one kilogram of essence, so it is also an expensive spice. However...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/02B01J13/02A61K8/92A61K47/44A61K47/40A61Q13/00
Inventor 王书民石启英周春生任有良刘彦峰李倩王香婷杨威李凯斌李仲谨
Owner SHANGLUO UNIV
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