The invention relates to a method for producing microparticles comprising at least one organic
active compound encapsulated by a shell of an organic
wall material, the method comprising i. Providing a water-immiscible liquid containing the organic
active compound to be encapsulated and at least one first shell-forming compound (SFC1); ii. Emulsifying the water-immiscible liquid obtained in step i. In an
aqueous medium to obtain an oil-in-water (o / w)
emulsion of the water-immiscible liquid in the
aqueous medium; iii. Adding at least one second shell-forming compound (SFC2) to the
aqueous medium or to the
emulsion obtained in step ii. Prior to or during performing step ii., thereby obtaining an
aqueous suspension of the microparticles; wherein the first shell-forming compound (SFC1) or the second shell-forming compound (SFC2) has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, in particular 1, 2 or 3 first reactive groups (RG1) selected from
isocyanate groups,
isothiocyanate groups, carbonyl
halide groups and carboxylic anhydride groups, per molecule, and the other shell-forming compound has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, per molecule, in particular 1, 2 or 3 second reactive groups (RG2) selected from the group consisting of hydroxyl,
thiol and primary amino groups, the first shell-forming compound (SFC1) or the second shell-forming compound (SFC2) having only one reactive group and the other shell-forming compound having 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, in particular 1, 2 or 3 reactive groups. The invention also relates to microparticles obtainable by this process and to the use thereof.