The present application relates to a topical composition comprising a compound capable of covalently binding to
skin and an
excipient suitable for topical administration, wherein the compound capable of covalently binding to
skin is a compound of formula (I), or a
tautomer and / or a pharmaceutically acceptable salt thereof, wherein R1 represents
hydrogen or a protective group hydrolysable under physiological conditions after application of the topical composition onto
skin; wherein L1, L2 and L3 independently from each other represent a
linker group or are absent, wherein A1, A2 and A3 independently from each other represent a) a C1-C30
moiety, H, hydroxyl, amino, or a
halogen, or b) a C1-C60
moiety or polymeric
moiety; wherein at least one of A1, A2 and A3 is a C1-C60 moiety or polymeric moiety of group b); wherein the C1-C60 moiety or polymeric moiety of group b) is b1) configured to act as a skin
moisturizer, a
pesticide, a
skin whitening agent, or a pharmaceutical; and / or b2) configured to act as a skin
moisturizer, a
pesticide, a
skin whitening agent, a fragrance or a pharmaceutical after being cleaved off of the 3,4-dihydro- 2H-
pyran moiety; and wherein L1-A1 and L2-A2 do not represent a moiety comprising an unsaturated C-C or C-N bond in alpha-position to the
carbon atom marked "a" and "b", respectively.