35results about How to "Good inclusion effect" patented technology

A preparation method of a rose essence beta-cyclodextrin polymer microsphere inclusion compound comprises the following steps: preparing a beta-cyclodextrin polymer microsphere by an inverse emulsion polymerization method; dissolving rose essential oil in a small amount of anhydrous ethanol; including the solution with the beta-cyclodextrin polymer microsphere by a saturated aqueous solution method; and after completion of inclusion, eluting and performing vacuum decompressed drying to obtain an inclusion product. The preparation method of the rose essence beta-cyclodextrin polymer microsphere inclusion compound takes the beta-CD (cyclodextrin) as a matrix which is crosslinked by epichlorohydrin, and uses the beta-CD microsphere which is synthesized by the inverse emulsion polymerization method, so that not only the original cavity structure and the slow-release and controlled-release and identification capabilities of the beta-CD are kept, but also the hydrophobicity of a beta-CD cavity is improved, the inclusion is promoted and the inclusion rate is improved; and due to intermolecular synergistic inclusion after beta-cyclodextrin polymerization, so that rose essence and a substance with similar structure and solubility to the rose essence can be firmly clamped, thus playing a relatively good slow-release effect.

The invention relates to a tylvalosin tartrate soluble powder and a preparation method thereof. The method comprises the steps of mixing hydroxypropyl-beta-cyclodextrin and water and stirring until dissolved to obtain a first liquid; mixing the first liquid, a tylvalosin tartrate crude drug and a pH regulator in a low-temperature water bath and stirring until a clear liquid is obtained; and carrying out spray drying on the obtained clear liquid through a spray drying tower to obtain powder, namely a finished product of tylvalosin tartrate soluble powder. The prepared tylvalosin tartrate soluble powder is capable of masking the drug odor, and is high in solubility and high in stability. The preparation method is high in operability, high in drug loading capacity and good in inclusion effect.

The invention relates to a hydroxypropyl-beta-cyclodextrin inclusion compound of ginseng essential oil, a preparation method and application. The ginseng essential oil is a liposoluble constituent indissoluble in water, and is generally applied to ginsenoside preparations in clinics. The hydroxypropyl-beta-cyclodextrin inclusion compound of the invention is prepared from the following ingredients in percentage by weight: 1 of ginseng essential oil and 1 to 100 of hydroxypropyl-beta-cyclodextrin. The ginseng essential oil is added into a water solution containing the hydroxypropyl-beta-cyclodextrin, the ultrasonic treatment is carried out at 30 DEG C at 40 KHz, and then, water-soluble inclusion compounds are formed through being dried. The hydroxypropyl-beta-cyclodextrin inclusion compound can be used as ingredients of medicine for treating body deficiency and prostration, faint pulse and cold extremities, spleen deficiency and poor appetite, pulmonasthenia cough, body fluid deficiency and thirst, internal heat thirst, macronosia deficiency, cardiac shock and the like.

The invention belongs to the technical field of traditional Chinese medicine preparation and particularly relates to a preparation method of an aromatic decocting-free traditional Chinese medicine agent. According to the preparation method, effective ingredients of volatile oil contained in aromatic traditional Chinese medicines are extracted with a supercritical CO2 extraction technology, extraction is performed with an ultrasonic-microwave synergic extraction technology, an extraction solution is filtered through a microfiltration technology, filtrate is concentrated and mixed with the volatile oil after inclusion, the mixture is dried and smashed, and the aromatic decocting-free traditional Chinese medicine agent is prepared from extract fine powder. The problems that the utilization rate of raw materials is low, effective ingredients of the volatile oil are not completely extracted and are severely damaged, the extraction efficiency is low and the like during extraction of traditional Chinese medicinal materials with a conventional method are solved; the whole technological process is simple to control, green and environment-friendly, the technological steps have synergistic interaction, accordingly, the extraction efficiency of the preparation method is higher, the effective ingredients are effectively protected, and the utilization rate of the aromatic traditional Chinese medicinal materials is increased.

The invention provides a cyclodextrin super-molecular micro-capsule and a preparation method thereof. The method comprises the following steps: (A) uniformly mixing traditional Chinese medicine volatile oil and beta-cyclodextrin to obtain a mixture; (B) introducing water into the mixture, introducing CO2 gas, carrying out inclusion by controlling the temperature being 30-100 DEG C and pressure being 8-40MPa, and relieving the pressure after a period of inclusion to obtain a product; and drying the product to obtain the cyclodextrin super-molecular micro-capsule. The cyclodextrin super-molecular micro-capsule has an encapsulation rate of over 50 percent. The method has the beneficial effects of simple method, no organic solvent in preparation process, environmental friendliness and the like.

Disclosed herein are a method for preparation of an inclusion-complex including a physiologically active hydrophobic substance in cjclodextrin and a derivative thereof, and use of the inclusion-complex prepared by the same. More particularly, the present invention provides a method for preparing an inclusion-complex, which includes agitating cjclodextrin and a derivative thereof in an agitator at high speed, spraying a physiologically active hydrophobic substance dissolved in alcohol onto the agitator, and drying and crushing the mixture obtained from the preceding step and, in addition, use of the prepared inclusion-complex. The present inventive method has merits of reduced inclusion time and increased inclusion rate. The prepared inclusion-complex has excellent cell and collagen proliferation effects compared to physiologically active hydrophobic substances which were not inclusion processed, thereby being used in production of a cosmetic composition with improved anti-wrinkle and anti-ageing effects.

The invention discloses a low-carbon and low-silicon Al-Mn-Ti-Fe alloy for deoxidation and alloying of molten steel, which is prepared by the following raw materials by weight percent: 20-65% of Al, 1-20% of Mn, 0.5-15% of Ti, not more than 1.0% of C, not more than 1.5% of Si and the balance of Fe. The low-carbon and low-silicon Al-Mn-Ti-Fe alloy has the benefits that the iron alloy is characterized by high-efficient final deoxidation capacity, low-carbon and low-silicon, and can effectively improve the deoxidation of the molten steel, improve the inclusion capacity in steel, realize low carbon increase and silicon increase, and meet the production need of a low-carbon and low-silicon high-manganese type steel. The alloy has larger specific weight, so that the yielding rate of the alloy is high and the alloy can effectively reduce the consumption cost of the steelmaking final deoxidation alloy, simultaneously effectively solve the weakness of the conventional Al and Mn-containing alloy powdering through the reasonable micro-alloy component matching, and be stored for a long time without being powered. In addition, due to the existence of titanium in the Al-Mn-Ti-Fe alloy, the alloy can effectively improve the component organization of the high-strength and low-alloy steel and improve the corrosion resistance performance and the welding performance of the steel.

The invention provides a nitric oxide donor type non-steroidal anti-inflammatory drug beta-cyclodextrin or beta-cyclodextrin derivative inclusion compound as well as a preparation method and an application thereof. The nitric oxide donor type non-steroidal anti-inflammatory drug beta-cyclodextrin or beta-cyclodextrin derivative inclusion compound comprises a nitric oxide donor type non-steroidal anti-inflammatory drug and beta-cyclodextrin or a beta-cyclodextrin derivative, wherein the molar ratio of the nitric oxide donor type non-steroidal anti-inflammatory drug to beta-cyclodextrin or the beta-cyclodextrin derivative is 1: 1-1: 25. The inclusion compound has high bioavailability and good stability. The preparation method of the inclusion compound, provided by the invention, has the advantages that that the complete separation of the inclusion compound from medicinal raw materials which are not included is realized, the medicinal raw materials which are not included can be completely recycled, and the cost is reduced. The inclusion rate of the preferable preparation method reaches above 70%.

The invention relates to a tylvalosin tartrate soluble powder and a preparation method thereof. The method comprises the steps of mixing hydroxypropyl-beta-cyclodextrin and water and stirring until dissolved to obtain a first liquid; mixing the first liquid, a tylvalosin tartrate crude drug and a pH regulator in a low-temperature water bath and stirring until a clear liquid is obtained; and carrying out spray drying on the obtained clear liquid through a spray drying tower to obtain powder, namely a finished product of tylvalosin tartrate soluble powder. The prepared tylvalosin tartrate soluble powder is capable of masking the drug odor, and is high in solubility and high in stability. The preparation method is high in operability, high in drug loading capacity and good in inclusion effect.

The invention discloses a preparation method for steady-state soybean lecithin. The method comprises: dissolving hydroxypropyl-beta-cyclodextrin in distilled water, dissolving soybean lecithin in absolute ethanol, and then slowly dropwise adding the soybean lecithin solution into the hydroxypropyl-beta-cyclodextrin solution, wherein the mass ratio of hydroxypropyl-beta-cyclodextrin to soybean lecithin is 0.9:1-7.2:1; reacting with stirring at 30-70 DEG C for 1-7 h; cooling to room temperature, standing for 12-36 h, performing pumping filtration, performing freeze drying on the filtrate, and crushing to obtain the product. The product keeps original multiple health-care efficacy of soybean lecithin, and also overcomes the disadvantages such as moisture absorbing easiness, oxidation easiness, dissolving difficulty and bonding dispersing difficulty of soybean lecithin products, stead state of soybean lecithin is realized, and soybean lecithin can be effectively used as health food, food auxiliary agents, functional substance and the like for a relatively long time.

The invention discloses a preparation technology of a special pelteobagrus fulvidraco feed being reasonable in formula and low in case-fatality rate. The preparation technology comprises the followingsteps of mixing and stirring nanometer silicon dioxide with an ethanol water solution, adding sepiolite powder and ethanediol, performing ultrasonic vibration, performing filtering, and performing drying so as to obtain pretreated stone powder; uniformly mixing ant powder with pork scraps, squid powder, yellow mealworms, corn flour, grass meal, rapeseed meal, luffa flowers and the pretreated stone powder, and performing crushing so as to obtain a pretreatment main material; and under the state of stirring, adding lard, sesame oil, betaine, pomelo peel powder, soybean phospholipid and a premixto the pretreated main material, performing uniform stirring, adding water, performing mixing, inflating steam, performing curing, performing granulation, and performing cooling so as to obtain the special pelteobagrus fulvidraco feed being reasonable in formula and low in case-fatality rate. The special pelteobagrus fulvidraco feed disclosed by the invention is rich in nutrition and reasonable in formula, is not liable to disperse when being in contact with water, and is conveniently eaten by the pelteobagrus fulvidraco; and according to the special pelteobagrus fulvidraco feed, the immunityof the pelteobagrus fulvidraco can be effectively improved, the disease resistance of the pelteobagrus fulvidraco is strengthened, and the case-fatality rate of the pelteobagrus fulvidraco is low.

The invention relates to a Ganciclovir freeze-dry preparation for injection, comprising 50-250 parts of Ganciclovir and 100-200 parts of hydroxypropyl-beta-cyclodextrin. The invention also relates to a preparation method of the Ganciclovir freeze-dry preparation for injection. In the preparation process of the Ganciclovir freeze-dry preparation, Ganciclovir freeze-dry preparation can be dissolvedinto solvent when the pH value is almost neutral to improve the compliance for clinical application; freeze-dry time is shortened to be 22-26 hours, thus improving product quality, saving energy and lowering consumption.

Disclosed are a carboxymethyl-hydroxypropyl-β-cyclodextrin and preparation method thereof, the carboxymethyl-hydroxypropyl-β-cyclodextrin being a β-cyclodextrin derivative mixedly substituted by carboxymethyl and hydroxypropyl, the derivative being: n-(2, 3, 6-O-carboxymethyl)-m-(2, 3, 6-O-2-hydroxypropyl)-β-cyclodextrin. The substituted groups of each mole of cyclodextrin contain n carboxymethyl and m hydroxypropyl, m being the number of connections to hydroxypropyl in each mole of cyclodextrin derivative, that is, the average degree of substitution of hydroxypropyl, and n being the number of connections to carboxymethyl in each mole of cyclodextrin derivative, that is, the average degree of substitution of carboxymethyl, where m is a number selected from 1 to 6 and n is a number selected from 1 to 6. The present invention acts as a medical excipient, and has the features of low hemolytic property, low toxicity, and strong solubility.

A method for improving inclusion performance of an adjuvant is disclosed. The method includes (1) purifying and drying the adjuvant; and (2) adding the adjuvant into a mixed solvent to prepare a saturated solution, adding a medicine with the mole ratio of the medicine to the adjuvant being 1:(3-5), and performing inclusion under stirring at 50-70 DEG C. The method allows the inclusion rate of an inclusion compound prepared by beta-cyclodextrin to be greatly increased and facilitates inclusion performance of the pharmaceutical adjuvant beta-cyclodextrin. Through infrared, ultraviolet and microscopic analysis identification, the structure and performance of the inclusion compound formed by the medicine molecule and the beta-cyclodextrin are not changed. An effective technical guidance for a pharmacy enterprise is provided.

The invention discloses a special feed for broiler chicken in a brooding period. The special feed is prepared from, by weight, 5-15 parts of corns, 2-10 parts of fish meal, 2-10 parts of semen coicis, 2-8 parts of sorghum, 2-6 parts of bean pulp, 1-5 parts of peanut meal, 6-10 parts of shrimp meal, 1-5 parts of modified wheat bran, 1-2 parts of sodium carboxymethylcellulose, 1-2 parts of fermented bioprotein, 1-2 parts of grass meal, 2-6 parts of maize germ meal, 1-2 parts of shell powder, 2-5 parts of sepiolite powder, 1-2 parts of sodium bicarbonate, 0.001-0.004 part of mannose, 0.002-0.008 part of phytase, 0.004-0.008 part of amylase and 0.5-1.2 parts of xylanase. The special feed is balanced in nutrition, moderate in viscosity, great in formability, easy for the broiler chicken in the brooding period to eat and high in feed conversion rate and is capable of increasing the content of beneficial bacteria in intestinal tracts of the broiler chicken in the brooding period, effectively regulating intestinal flora balance and decreasing incidence of diseases.

The invention relates to a method for reducing irritation of paper-making tobacco sheets, and belongs to the field of paper-making tobacco sheet preparation. The method comprises the following steps:carrying out alcohol extraction and concentration on tobacco powder to obtain an alcohol-soluble concentrate; uniformly mixing the alcohol-soluble concentrate with an alcohol-soluble extract of a plant, glycerol, an Amadori compound, monoglyceride and a sweetening agent to obtain an alcohol-soluble coating solution; uniformly mixing the alcohol-soluble coating solution with a carrier solution, adding alcohol-soluble protein, and uniformly mixing to obtain a carrier alcohol-soluble coating liquid; adding the carrier alcohol-soluble coating liquid into a conventional tobacco sheet coating liquidto prepare a coating liquid; and adding the coating liquid into a tobacco sheet paper base, and drying to obtain the tobacco sheet. Although the content of harmful components such as tar is low, thecontent of carbon monoxide is high, the drying feeling is serious, irritation is large, smoke is not coordinated, and wood gas is serious in an existing tobacco sheet, so irritation of the papermakingmethod tobacco sheet is reduced.

The invention provides a method for flotation of copper from low-grade copper sulphide ore with high pyrrhotite content, which comprises the following steps: breaking raw ore into powder, adding lime and CD-2, and carrying out wet grinding to obtain primary ore pulp; rough concentrate and roughed tailings are obtained through multiple times of copper roughing on the primary ore pulp; copper scavenging is conducted on the roughing tailings for multiple times, copper pre-concentration is conducted on the rough concentrate, and pre-concentration concentrate and pre-concentration tailings are obtained; and performing copper fine scavenging on the pre-concentrated tailings, adding lime, CD-2 and sodium sulfide into the pre-concentrated concentrate, performing wet grinding to obtain secondary ore pulp, and performing four times of copper concentration and two times of copper fine scavenging on the secondary ore pulp to obtain copper concentrate and tailings. According to the method, pre-concentration operation is set, concentration is increased, small tailings are discharged, accumulation of pyrrhotite is avoided, the efficient inhibitor CD-2 is combined, the adverse effect of the efficient inhibitor CD-2 on copper flotation is reduced, and high-grade copper concentrate is obtained; the problem that the recovery index of copper in the low-grade high-pyrrhotite copper sulfide ore is not ideal is solved, and an effective method is provided for development and utilization of copper ore resources.

The invention discloses a special low-case-fatality-rate feed for variegated carps. The special low-case-fatality-rate feed comprises the following raw materials in parts by weight: 5-12 parts of soybeans, 10-20 parts of natural fish meal, 8-15 parts of peanut meal, 5-10 parts of freshwater mussel meat, 20-40 parts of corn, 30-40 parts of puffed sweet potato powder, 20-30 parts of animal source protein, 1-2 parts of a waterproof agent, 0.5-1.2 parts of soybean phospholipid, 0.15-0.3 part of betaine, 1-4 parts of distillers' grains, 1-2 parts of a premix, and 2-4 parts of a sepiolite composite.The special low-case-fatality-rate feed is rich in nutrition and reasonable in formula, is not liable to disperse when being in contact with water, and is convenient to eat by the variegated carps. According to the special low-case-fatality-rate feed, the immunity of the variegated carps can be effectively improved, the disease resistance of the variegated carps can be strengthened, and the case-fatality rate of the variegated carps is low.

Volatile oil spray grinding inclusion equipment belongs to the field of medicine and food equipment. The equipment mainly comprises a colloid mill (1), a high-efficiency atomizing nozzle (2) and a pressure-bearing liquid material tank (3) for storing and conveying volatile oil. A high-efficiency atomizing nozzle (2) is arranged above a feeding hopper (13) of the colloid mill (1), and the pressure-bearing liquid tank (3) is communicated with a liquid inlet pipe (7) of the high-efficiency atomizing nozzle (2) through a liquid pipe (8). The volatile oil spray grinding inclusion equipment device is reasonable in structure, convenient to operate and suitable for cyclodextrin grinding and inclusion of volatile oil, a volatile oil solution is continuously conveyed to the efficient atomizing nozzle (2) from the pressure-bearing liquid tank (3) by means of compressed air, and the volatile oil solution is efficiently and dispersedly sprayed into water-cyclodextrin mixed liquid in the colloid mill (1) in a mist form through the efficient atomizing nozzle (2); efficient dispersion, mixing and clathration of the volatile oil are achieved, the clathration rate of the volatile oil is increased, and the clathration effect is optimized.

The present invention discloses a nutrition enriched feed for lobsters with a strong disease resistance ability. The feed comprises the following raw materials in parts by weight: 10-20 parts of earthworms, 15-35 parts of bean worm powder, 20-28 parts of pumpkin flour, 4-14 parts of high gluten flour, 20-32 parts of corn flour, 15-24 parts of full fat rice bran, 4-18 parts of rapeseed meal, 10-20parts of grass powder, 1-2 parts of olive oil, 2-4 parts of rapeseed oil, 1-2 parts of a sepiolite compound, 0.01-0.04 part of betaine, 2-8 parts of rice wine, 1-3 parts of soybean lecithin and 2-5 parts of a premix. The feed is rich in nutrition, reasonable in formula, not easy to disperse in water and convenient for food intake of the lobsters, and can effectively improve immunity of the lobsters, enhance the disease resistance of the lobsters, and enable a mortality of the lobsters to be low.