Cyclodextrin super-molecular micro-capsule and preparation method thereof

A cyclodextrin and supramolecular technology, applied in the field of microcapsule production, can solve the problems of complicated process, organic solvent residue, low encapsulation efficiency, etc., and achieve the effects of good sustained release effect, favorable release and convenient operation

Active Publication Date: 2015-05-20
华润三九(郴州)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ubiquitous problems of these supramolecular microcapsule preparation methods are low encapsulation efficiency, complex process, and residual organic solvents in supramolecular microcapsules.

Method used

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  • Cyclodextrin super-molecular micro-capsule and preparation method thereof
  • Cyclodextrin super-molecular micro-capsule and preparation method thereof
  • Cyclodextrin super-molecular micro-capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 1.56g of menthol and 15.6g of β-cyclodextrin in a 500ml stoppered round-bottom flask for mixing, then pour it into a filter paper tube, put the filter paper tube into a 1L reaction kettle, and add 50ml of water to the reaction kettle As a co-solvent, heat the reactor so that its temperature is between 30-100°C, and feed about 1kg of CO into the reactor 2 gas, make the kettle pressure between 8-10MPa, keep it for 24h, release the pressure within 10min, take out the filter paper tube, and vacuum dry it at 20-50℃ to get cyclodextrin supramolecular microcapsules, and measure the encapsulation The rate is 56.85%. The instrumental analysis spectrum of the cyclodextrin supramolecular microcapsules formed by it is as attached Figure 1-2 shown;

[0033] The measuring method of specific encapsulation efficiency is as follows:

[0034] Encapsulation efficiency is an important index to measure the preparation process of supramolecular microcapsules. The encapsulation effici...

Embodiment 2

[0044] Weigh 0.19g of angelica oil and 15.6g of β-cyclodextrin in a 500ml stoppered round-bottomed flask for mixing, then pour it into a filter paper tube, put the filter paper tube into a 1L reaction kettle, and add 200ml of water to the reaction kettle As a co-solvent, feed about 1 kg of CO into the kettle 2 Gas, so that the temperature in the reactor is 30-80 ° C, the pressure is 30-40 MPa, after keeping for 0.5 hours, the pressure is released within 1-60 minutes, the filter paper tube is taken out, and after drying, the supramolecular microcapsules of volatile oil are obtained. The encapsulation rate was 85.37%. The encapsulation rate was measured with artebenolactone as an index component. The method for measuring the encapsulation rate was the same as in Example 1.

Embodiment 3

[0046] Weigh 1.48g of star anise oil and 15.6g of β-cyclodextrin in a 500ml stoppered round bottom flask to mix well, then pour it into a filter paper tube, put the filter paper tube into a 1L reaction kettle, and add 10ml of Water is used as a co-solvent, and about 1kg of CO is introduced into the kettle 2 gas, so that the temperature in the reactor is 60°C and the pressure is 35MPa. After keeping it for 8 hours, the pressure is released within 1-60min. The encapsulation rate was 88.25%. The encapsulation rate was measured with anethole as an index component. The method for measuring the encapsulation rate was the same as that in Example 1.

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Abstract

The invention provides a cyclodextrin super-molecular micro-capsule and a preparation method thereof. The method comprises the following steps: (A) uniformly mixing traditional Chinese medicine volatile oil and beta-cyclodextrin to obtain a mixture; (B) introducing water into the mixture, introducing CO2 gas, carrying out inclusion by controlling the temperature being 30-100 DEG C and pressure being 8-40MPa, and relieving the pressure after a period of inclusion to obtain a product; and drying the product to obtain the cyclodextrin super-molecular micro-capsule. The cyclodextrin super-molecular micro-capsule has an encapsulation rate of over 50 percent. The method has the beneficial effects of simple method, no organic solvent in preparation process, environmental friendliness and the like.

Description

technical field [0001] The invention relates to the field of microcapsule production, in particular to a cyclodextrin supramolecular microcapsule and a preparation method thereof. Background technique [0002] Volatile oil of traditional Chinese medicine is a general term for a kind of oily liquid that is volatile and can be distilled out with water vapor. It has many aromas and is widely distributed in Chinese medicinal materials. Due to the poor stability of volatile oil, the pharmaceutical preparations containing volatile oil are easy to volatilize and oxidize, which often leads to a decrease in the volatile oil content in the drug within the validity period, which affects the quality of the drug, and also makes the clinical efficacy unguaranteed. The volatile oil can be encapsulated by β-cyclodextrin. After encapsulation, the volatile oil enters the cavity of β-cyclodextrin to form supramolecular microcapsules, which can prevent the volatile oil from volatilization, oxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/48
Inventor 雷华平符国成龚小兵
Owner 华润三九(郴州)制药有限公司
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