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Hydroxypropyl-beta-cyclodextrin inclusion compound of ginseng essential oil, preparation method and application

A technology of cyclodextrin inclusion complex and hydroxypropyl group, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and drug combinations, etc. Improved bioavailability without hemolytic effect

Inactive Publication Date: 2010-10-20
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Retrieval of other documents and patents at home and abroad, no patents and documents related to the inclusion of ginseng volatile oil with hydroxypropyl-β-cyclodextrin were found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1g of ginseng volatile oil and 5g of hydroxypropyl-β-cyclodextrin, dissolve all hydroxypropyl-β-cyclodextrin in 200ml of water for injection, and ultrasonicate at 30°C and 40KHz, add ginseng volatile oil dropwise to hydroxyl Propyl-β-cyclodextrin solution, after all the addition, continue to sonicate for 0.5 to 24 hours, filter with a 0.45 μm or 0.22 μm microporous membrane, and freeze-dry the filtrate to obtain a loose white powder, which is purified by gas chromatography (GC) -MS) confirmed the formation of inclusion complexes of ginseng volatile oil and hydroxypropyl-β-cyclodextrin. It is the inclusion compound of hydroxypropyl-β-cyclodextrin of ginseng volatile oil. The clathrate obtained can also be washed with ether to remove the volatile oil of ginseng that is not clathrated.

[0022] The clathrate of the present invention can also be prepared by other methods, such as the stirring method, that is, the aqueous solution containing hydroxypropyl-β-cyclodextri...

Embodiment 2

[0026] The clathrate powder obtained in Example 1 was washed with ether, and the ether was evaporated to obtain a white clathrate powder. Example 3

Embodiment 3

[0027] Others are the same as in Example 1, and the ultrasonic oscillation is changed to strong magnetic stirring, and the clathrate solution is filtered through a 0.45 μm microporous membrane, and the filtrate is freeze-dried to obtain a white loose powder. It is confirmed by thin-layer chromatography that an clathrate is formed. The inclusion rate is 80%.

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Abstract

The invention relates to a hydroxypropyl-beta-cyclodextrin inclusion compound of ginseng essential oil, a preparation method and application. The ginseng essential oil is a liposoluble constituent indissoluble in water, and is generally applied to ginsenoside preparations in clinics. The hydroxypropyl-beta-cyclodextrin inclusion compound of the invention is prepared from the following ingredients in percentage by weight: 1 of ginseng essential oil and 1 to 100 of hydroxypropyl-beta-cyclodextrin. The ginseng essential oil is added into a water solution containing the hydroxypropyl-beta-cyclodextrin, the ultrasonic treatment is carried out at 30 DEG C at 40 KHz, and then, water-soluble inclusion compounds are formed through being dried. The hydroxypropyl-beta-cyclodextrin inclusion compound can be used as ingredients of medicine for treating body deficiency and prostration, faint pulse and cold extremities, spleen deficiency and poor appetite, pulmonasthenia cough, body fluid deficiency and thirst, internal heat thirst, macronosia deficiency, cardiac shock and the like.

Description

Technical field: [0001] The invention relates to a hydroxypropyl-beta-cyclodextrin inclusion compound of ginseng volatile oil used for injection and oral administration, which has the functions of invigorating vital energy, invigorating the spleen and benefiting the lung, promoting body fluid and calming the nerves, as well as its formulation and preparation method. Background technique: [0002] Ginseng is the dried root of Araliaceae plant Pananx ginseng C.A.Mey. The cultivated ones are called "garden ginseng" and the wild ones are called "mountain ginseng". It is mainly produced in the northeastern provinces of my country, and Fusong County in Jilin is the best. It is used for physical weakness, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, coughing, thirsty body fluid wound, internal heat and thirst, chronic illness and deficiency, cardiogenic shock, etc. [0003] The volatile oil of ginseng is a fat-soluble component, which is difficult to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K47/48A61K9/20A61K9/48A61P1/14A61P7/08A61P9/00A61P37/04A61K47/69
Inventor 王阳田亚新李殿鹏
Owner HEILONGJIANG UNIV
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