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Norfloxacin capsules and preparation method thereof

A technology for norfloxacin and capsules, which is applied in the field of norfloxacin capsules and their preparation, can solve the problems of unstable drug effect, difficulty in meeting the medication needs of patients and the like, and achieves high bioavailability and low dissolution rate. The effect of changing and stable drug performance

Inactive Publication Date: 2017-02-15
合肥美利康医药技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug effect of the common preparation of norfloxacin is unstable and requires frequent administration, making it difficult to meet the medication needs of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A norfloxacin capsule, every 1000 described norfloxacin capsules comprises the following components: norfloxacin 45g, β-cyclodextrin 65g, polyethylene glycol 400 10g, mannitol 30g, Lactose 30g, microcrystalline cellulose 16g, low-substituted hydroxypropyl cellulose 10g, sodium carboxymethyl starch 20g, talcum powder 12g.

[0022] The preparation method of norfloxacin capsule, comprises the following steps:

[0023] (1) Pass norfloxacin, β-cyclodextrin, mannitol, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, and talc through a 120-mesh sieve, and take fine powder for later use;

[0024] (2) Weigh norfloxacin fine powder, β-cyclodextrin fine powder, and polyethylene glycol 400 according to the proportion of ingredients, mix norfloxacin and polyethylene glycol evenly, grind for 1 hour, then add β-cyclodextrose fine, mix evenly, then add water and knead into a paste, continue to grind for 5 hours until the β-cyc...

Embodiment 2

[0028] A norfloxacin capsule, every 1000 described norfloxacin capsules comprises the following components: norfloxacin 45g, β-cyclodextrin 66g, polyethylene glycol 400 8g, mannitol 32g, Lactose 25g, microcrystalline cellulose 18g, low-substituted hydroxypropyl cellulose 8g, carboxymethyl starch sodium 22g, magnesium stearate 10g.

[0029] The preparation method of norfloxacin capsule, comprises the following steps:

[0030] (1) Pass norfloxacin, β-cyclodextrin, mannitol, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, and magnesium stearate through an 80-mesh sieve respectively, and take The fine powder of each component is ready for use;

[0031] (2) Weigh norfloxacin fine powder, β-cyclodextrose fine powder, and polyethylene glycol according to the proportion of ingredients, mix norfloxacin and polyethylene glycol evenly, after grinding for 0.5h, add β-cyclodextrose Finely mix evenly, then add water and knead into...

Embodiment 3

[0035] A norfloxacin capsule, every 1000 described norfloxacin capsules comprises the following components: norfloxacin 45g, β-cyclodextrin 64g, polyethylene glycol 400 12g, mannitol 28g, Lactose 25g, microcrystalline cellulose 14g, low-substituted hydroxypropyl cellulose 11g, sodium carboxymethyl starch 18g, micropowder silica gel 14g.

[0036] The preparation method of norfloxacin capsule, comprises the following steps:

[0037] (1) Pass norfloxacin, β-cyclodextrin, mannitol, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, and micropowder silica gel through an 80-mesh sieve, and take each group fine powder for later use;

[0038] (2) Weigh norfloxacin fine powder, β-cyclodextrin fine powder, and polyethylene glycol according to the ingredient ratio, mix norfloxacin and polyethylene glycol evenly, grind for 1 hour, and then add β-cyclodextrin Mix evenly, then add water and knead into a paste, continue to grind for 8...

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PUM

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and in particular to norfloxacin capsules and a preparation method thereof. Every 1000 pieces of the norfloxacin capsules consist of the following components: 45g of norfloxacin, 64-66g of beta-cyclodextrin, 8-12g of polyethylene glycol, 28-32g of mannitol, 25-35g of lactose, 14-18g of microcrystalline cellulose, 8-11g of low-substituted hydroxypropyl cellulose, 18-22g of sodium carboxymethyl starch and 10-14g of a lubricant. The norfloxacin capsules provided by the invention are high in dissolution and release speeds, high in bioavailability and stable in drug performance, and the dissolution rate of the norfloxacin capsules, which are preserved for a long time, cannot be changed.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a norfloxacin capsule and a preparation method thereof. Background technique [0002] Norfloxacin, also known as Norfloxacin, Linbuxing, etc., is a third-generation quinolone antibacterial with broad-spectrum antibacterial effects, especially high antibacterial activity against aerobic Gram-negative bacilli, and has good antibacterial effects against the following bacteria in vitro : Most bacteria of Enterobacteriaceae, including Enterobacter, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, etc. Bacteria, Vibrio, Yersinia, etc. Norfloxacin also has antibacterial activity against multidrug-resistant bacteria in vitro. It also has good antibacterial effect on penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrhalis. Norfloxacin is a fungicide that inhibits DNA synthesis and replication by acting on the A subuni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/496A61K47/10A61K47/61A61P31/04
CPCA61K9/4866A61K31/496
Inventor 赵冬生方从彬方存杰孙明哲孙延标徐奎
Owner 合肥美利康医药技术股份有限公司
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