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Dihydromyricetin cyclodextrin inclusion compound and preparation method thereof

A technology of dihydromyricetin and cyclodextrin is applied in the field of dihydromyricetin cyclodextrin inclusion complex and its preparation, and can solve the problem of low solubility and low bioavailability of β-cyclodextrin inclusion complex. problems, to achieve the effect of easy control of production conditions, improved solubility, and high content

Inactive Publication Date: 2015-06-03
江苏丰园生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are non-patent literature published (Liang Xiaolan et al., Journal of Hunan University of Traditional Chinese Medicine, 2011, Research on the preparation process of dihydromyricetin β-cyclodextrin inclusion compound in No1 vine tea), although β-cyclodextrin can be used very well Embed dihydromyricetin, but there are disadvantages such as low solubility of dihydromyricetin β-cyclodextrin inclusion complex in water and low bioavailability

Method used

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  • Dihydromyricetin cyclodextrin inclusion compound and preparation method thereof
  • Dihydromyricetin cyclodextrin inclusion compound and preparation method thereof
  • Dihydromyricetin cyclodextrin inclusion compound and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0033] An inclusion compound of dihydromyricetin and cyclodextrin, including cyclodextrin and dihydromyricetin embedded in the cavity of cyclodextrin, forming dihydromyricetin as the object with cyclodextrin as the main molecule Molecular clathrates.

[0034] The cyclodextrin is one or two of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin and cyclodextrin derivatives and any combination thereof.

[0035] The cyclodextrin derivatives include: hydroxypropyl-β-cyclodextrin, glucose cyclodextrin, maltose cyclodextrin, dihydroxypropyl-β-cyclodextrin, maltotriose cyclodextrin, methyl- β-cyclodextrin, carboxymethylcyclodextrin, sulfanylcyclodextrin.

[0036] As a preferred solution of the previous step, the cyclodextrin is γ-cyclodextrin.

[0037] As a preferred solution of the previous step, the cyclodextrin derivative is hydroxypropyl-β-cyclodextrin.

[0038] As a preferred solution in the previous step, the dihydromyricetin is dihydromyricetin extracted from plants of the genus...

Embodiment 2

[0041] A preparation method of cyclodextrin and dihydromyricetin inclusion complex, characterized in that it comprises the following steps:

[0042] (1) Dissolving 100-500 parts of dihydromyricetin in 100-39600 parts of solvent A to make a dihydromyricetin solution;

[0043] (2) Add 200-600 parts of cyclodextrin and / or cyclodextrin derivatives directly to the above dihydromyricetin solution and / or dissolve 200-600 parts of cyclodextrin and / or cyclodextrin derivatives In 100-39600 parts of solvent B, make cyclodextrin and / or cyclodextrin derivative solution and add the above dihydromyricetin solution;

[0044](3) Cut the mixed solution with a shearing machine, and when a complex is formed with a microscope, the inclusion is completed, and then spray-dried with a spray tower to obtain a powder solid dihydromyricetin and cyclodextrin and / or Cyclodextrin derivative inclusion compound

Embodiment 3

[0046] (1) Weigh 100-500 parts of dihydromyricetin and dissolve in 100-39600 parts of pure water, keep the dissolution temperature at 60-80°C to make dihydromyricetin suspension;

[0047] (2) Slowly add 200-600 parts of cyclodextrin or cyclodextrin derivatives to the above-mentioned dihydromyricetin suspension, and use a shearer at high speed to cut at 3000-8000r / min for inclusion, The temperature of the system is kept between 60-80°C, and the treatment time is 30-240min to make a dihydromyricetin inclusion compound solution;

[0048] (3) Spray-dry the above-mentioned dihydromyricetin inclusion compound solution with a spray tower at an inlet air temperature of 180-200°C and an outlet air temperature of 70-80°C to obtain dihydromyricetin cyclodextrin inclusion compound powder.

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Abstract

The invention discloses a dihydromyricetin cyclodextrin inclusion compound, which comprises cyclodextrin and dihydromyricetin, wherein the dihydromyricetin is embedded into a cyclodextrin cavity; and the inclusion compound employing the cyclodextrin as a host molecule and dihydromyricetin as a guest molecule is formed. The dihydromyricetin cyclodextrin inclusion compound has the beneficial effects that 1 the dihydromyricetin cyclodextrin inclusion compound is embedded by the cyclodextrin, and the solubility, the stability and the bioavailability of the dihydromyricetin are improved; 2 the preparation method of the dihydromyricetin cyclodextrin inclusion compound disclosed by the invention is simple in process and suitable for industrialized production; 3 a spray drying process is adopted, the process from spray drying to dust collection is finished within 20 seconds, the problem of product oxidation in the drying process is avoided, the method is simple in process, simple and convenient to operate; the production conditions are easy to control, and the inclusion rate of the dihydromyricetin is high; and 4 the dihydromyricetin used by the dihydromyricetin cyclodextrin inclusion compound is extracted from vitaceae ampelopsis, and the dihydromyricetin in the vitaceae ampelopsis is high in content, and is a natural substance and free of toxicity.

Description

technical field [0001] The invention belongs to the field of biomedical products, and specifically relates to a dihydromyricetin cyclodextrin inclusion compound and a preparation method thereof, which can be applied to the industries of food, medicine and health care products. Background technique [0002] Dihydromyricetin is the main chemical component of a wild woody vine of the genus Vitis genus in the family Vitaceae. This kind of substance has many unique effects such as scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, and anti-inflammatory. Alcoholism, preventing alcoholic liver, fatty liver, inhibiting liver cell deterioration, reducing the incidence of liver cancer, etc., is a good product for protecting the liver, hangover and sobering up, and is widely used in food, medicine, and health care products. In the field of food, dihydromyricetin is mainly added to beverages to make health drinks, and added to baked foods to play an antioxidant role;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K47/48A23L1/09A61P39/06A61P31/04A61P3/08A61P3/06A61P11/00A61P31/00A61P7/02A61P35/00A61P29/00A61P25/32A61P1/16A23L29/30A23L33/105
Inventor 徐文峰
Owner 江苏丰园生物技术有限公司
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