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Cyclodextrin inclusion compound containing antibiotic components, a compounding method thereof and feed additive

A cyclodextrin inclusion compound and feed additive technology, which is applied in animal feed, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as strong odor, poor water solubility, and easy oxidation. Achieve the effect of simple preparation method and high inclusion rate

Inactive Publication Date: 2016-06-08
HUNAN JINGTIAN TECH IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a cyclodextrin inclusion compound of an antibacterial component, which not only solves the problems of poor palatability, strong irritation, poor water solubility, and easy Volatilization, easy oxidation, instability, strong odor and other problems have opened up a new way for the wide application of antibacterial ingredients; and the controlled release effect is good

Method used

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  • Cyclodextrin inclusion compound containing antibiotic components, a compounding method thereof and feed additive
  • Cyclodextrin inclusion compound containing antibiotic components, a compounding method thereof and feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Mix 100kg of allyl compound (garlic oil) with 500kg of dichloromethane, and pump into 2M with 900kg of β-cyclodextrin 3 In the rake dryer, stir at 40±5°C for 30 minutes, distill out the dichloromethane and unincorporated garlic oil, and cool and recycle for recycling. When the dichloromethane is fully recovered, the reactants are released and cooled to obtain the product garlic Oil β-cyclodextrin inclusion compound, garlic oil smell is very light, significantly lower than the smell of garlic oil adsorbed by ordinary adsorbents.

Embodiment 2

[0045] Stir 80kg 3-phenyl-2-propenal with 500kg petroleum ether with a boiling range of 60~90℃ and pump into 2M with 900kg β-cyclodextrin 3 In the rake dryer, stir at 70±5°C for 30 minutes, distill out petroleum ether and unincorporated 3-phenyl-2-propenal, and cool and recycle for recycling. When all petroleum ether is recovered, the reactants are released and cooled , The product is 3-phenyl-2-propenaldehyde β-cyclodextrin inclusion compound, the cinnamon smell is very light, and the smell of cinnamaldehyde adsorbed by ordinary adsorbents is obviously reduced, and the content of cinnamaldehyde is measured to be 7.95%.

Embodiment 3

[0047] Mix 120kg of methyl salicylate with petroleum ether with a boiling range of 90-120℃ and pump into 2M with 900kg of β-cyclodextrin 3 In the rake dryer, stir at 120±5°C for 30 minutes, distill out petroleum ether and unincorporated methyl salicylate, and cool and recover for recycling. When all petroleum ether is recovered, the reactants are discharged and cooled to obtain the product The methyl salicylate β-cyclodextrin inclusion compound, the measured wintergreen oil content is 11.96%.

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Abstract

The invention provides a cyclodextrin inclusion compound containing antibacterial components and a compounding method of the cyclodextrin inclusion compound. The cyclodextrin inclusion compound containing the antibacterial components is prepared from an inclusion agent and the antibacterial components, wherein the inclusion agent is cyclodextrin and / or a derivative of the cyclodextrin; a weight ratio of the inclusion agent and a component antibacterial agent is (0.5 to 500) : 1. The compounding method of the cyclodextrin inclusion compound comprises the following steps of mixing and stirring the inclusion agent, the component antibacterial agent and a solvent; completing inclusion; distilling to remove the solvent, thus obtaining the cyclodextrin inclusion compound. The cyclodextrin inclusion compound provided by the invention is used in the aspects of feed, a feed additive and the like and is used for replacing the functions of health protection, growth promotion, oxidation resistance and the like of existing feed antibiotic antibacterial drugs; according to the cyclodextrin inclusion compound provided by the invention, the problems of poor palatability, strong pungency, poor water solubility, easiness in volatilization, easiness in oxidation, instability, strong smell and the like caused by the existence of a single antibacterial component are solved, and a new path is developed for wide application of the component antibacterial agent; the controlled release effect is good.

Description

Technical field [0001] The present invention relates to the field of feed, in particular to a cyclodextrin inclusion compound of antibacterial components, a synthesis method thereof, and feed additives. Background technique [0002] Switzerland banned feed antibiotics in 1986, EU banned feed antibiotics in 2006, and the US FDA issued guidance documents in 2014. It plans to gradually ban feed antibiotics in the next three years. The "post-antibiotic era" has come. [0003] my country’s feed industry has developed vigorously in the 30 years since the 1980s, and has formed the world’s largest annual output of 197 million tons. Now it has entered an era of brutal competition with large mergers, large integrations, and extremely low profits. "Upper cutting iron" creates profits and saves or grows their own enterprises. It seems that there is not much preparation for the inevitable "post-antibiotic era". At this time, the development of an antibiotic substitute is imminent. [0004] Prev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/163A23K20/10A61K47/48A61K45/00A61P31/04A61P31/12A61P37/04A61P43/00
CPCA61K45/00
Inventor 周建成
Owner HUNAN JINGTIAN TECH IND CO LTD
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