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Fresh ginger essential oil and mixed cyclodextrin inclusion compound and preparation method thereof

A technology of mixing cyclodextrin and ginger essential oil, which is applied in the field of medicine, can solve the problems of low solubility of inclusion complexes, achieve the effects of easy control of production conditions, industrialized production, and simple operation

Inactive Publication Date: 2013-08-28
江苏丰园生物技术有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It has been reported in the literature that ginger essential oil was clathrated with β-cyclodextrin to form inclusion complexes, but the solubility of the inclusion complexes was low (<9g / L)

Method used

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  • Fresh ginger essential oil and mixed cyclodextrin inclusion compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Determination of the optimal ratio of α-cyclodextrin and β-cyclodextrin

[0020] Two different ratios of α-cyclodextrin and β-cyclodextrin were selected. After many experiments, the inclusion of mixed cyclodextrins with different proportions was carried out at the same temperature and inclusion time. According to the inclusion rate Choose the best ratio of α-cyclodextrin and β-cyclodextrin. The data in Table 1 are obtained through experiments:

[0021] Table 1 Determination table for optimal ratio of α-cyclodextrin and β-cyclodextrin

[0022]

[0023] Cyclodextrin cyclodextrin CD for short.

[0024] It can be seen from the experimental results that when the mixed cyclodextrin consists of 2 parts of α-cyclodextrin and 1 part of β-cyclodextrin by weight, the inclusion rate of ginger essential oil is the highest.

Embodiment 2

[0026] Mix 10 parts of cyclodextrin (the ratio of α-cyclodextrin and β-cyclodextrin is 2:1), 75 parts of water, heat to 70°C to make a saturated aqueous solution of mixed cyclodextrin, cool to 60°C , add 1 part of ginger essential oil drop by drop, and use a shearing machine to carry out clathrate under stirring at 5000r / min. The temperature of the system is kept at about 50°C. The inclusion compound solution of ginger essential oil was spray-dried to obtain a product, and the inclusion rate of ginger essential oil was 92.3%.

Embodiment 3

[0028] Mix 9 parts of cyclodextrin (the ratio of α-cyclodextrin and β-cyclodextrin is 2:1), 70 parts of water, heat to 60°C to make a saturated aqueous solution of mixed cyclodextrin, cool to 50°C , add 1 part of ginger essential oil dropwise, and use a shearing machine to carry out clathrate under stirring at 5000r / min. The temperature of the system is kept at about 55°C. The ginger essential oil inclusion compound solution was spray-dried to obtain a product, and the inclusion rate of the ginger essential oil was 94.8%.

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Abstract

The invention belongs to the field of a medical technology and particularly relates to a fresh ginger essential oil and mixed cyclodextrin inclusion compound and a preparation method of the fresh ginger essential oil and mixed cyclodextrin inclusion compound. The invention provides a technical scheme of carrying out inclusion on a mixture of alpha-cyclodextrin and beta-cyclodextrin and fresh ginger essential oil in water, so that the inclusion rate is improved, the solubility and the stability are increased and an organic solvent used in a production process is avoided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an inclusion compound of ginger essential oil and mixed cyclodextrin and a preparation method thereof. Background technique [0002] Ginger is the rhizome of the ginger plant, often used as a seasoning and traditional Chinese medicine. Ginger essential oil is the main component of ginger. It is a light yellow to yellow clear liquid with a unique spicy taste of ginger extracted by distillation. Ginger essential oil can be used to treat fractures, rheumatism, arthritis, colds and flu, coughs, skin injuries, carbuncles, nausea, skin pains, etc. However, the shortcomings of ginger essential oil's volatile and oxidative deterioration have seriously affected the inconvenience of ginger essential oil in preparation processing, storage, transportation and other aspects. In pharmaceutical applications, cyclodextrin mainly has the functions of stabilizing, preventing volatilization and ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K47/40C11B9/00A61P19/08A61P29/00A61P19/02A61P11/00A61P11/14A61P31/16A61P17/02A61P1/08
Inventor 徐文峰
Owner 江苏丰园生物技术有限公司
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