The invention discloses a multi-effect skin care composition, essence and a preparation method of the essence. The skin care composition includes the following components, in percentages by mass: 1 to2.5% of a natural extract, 0.1 to 0.5% of a yeast extract, 0.1 to 0.5% of polypeptide, and the balance of a substrate, wherein the natural extract is one or more selected from the group consisting ofpaeonia albiflora root, rosa canina fruit, origanum majorana leaf, rubus suavissimus leaf, leontopodium alpinum, ginkgo biloba leaf, rhodiola rosea, panax ginseng root, scutellaria baicalensis root,polygonum cuspidatum root, ledebouriella divaricata root, zizyphus jujuba fruit, citrus limonum, schizandra chinensis fruit, morus alba bark, tremella fuciformis, chamomilla recutita flower, centellaasiatica, melissa officinalis and salix alba bark. The plurality of natural extracts in the multi-effect skin care composition provided by the invention have the functions of moisturizing, anti-inflammatory and repairing cells; and the composition also contains the polypeptide and the yeast extract liquid, multiple active ingredients are compounded to repair damaged cells while keeping moisture and supplementing water, removes free radicals in skin, provides nutrient substances to the skin, and can restore the skin to an elastic and delicate state.