11 results about "Anticoccidial Agents" patented technology

Developed and provided are: an anticoccidial agent, and a using method thereof, where the anticoccidial agent has an excellent anticoccidial activity and can eliminate or minimize mass outbreak of coccidioses. Thus, provided are: an anticoccidial agent containing, as an active ingredient, a benzimidazole compound represented by General Formula (1), or a salt of the compound, and a method for using the agent. General Formula (1) is expressed as follows:wherein R1 typically represents haloalkyl; X typically represents oxygen; R typically represents alkyl; Y represents halogen; m denotes 0 or 1; Z represents alkyl or halogen; and n denotes 0, 1, or 2.

This invention provides a feed additive and compound feed for preventing and treating coccidiosis in broilers, comprising the following components: *Kluyveromyces martensii*, ferulic acid esterase, aminopeptidase, and glucanase. Preferably, the mass percentage of *Kluyveromyces martensii* is 30-40%; the mass percentage of ferulic acid esterase is 15-28%; the mass percentage of aminopeptidase is 15-25%; and the mass percentage of glucanase is 18-25%. Based on extensive research, this invention has determined that this combination has a significant effect on coccidiosis control in broilers, effectively improving broiler production performance indicators, increasing economic benefits, and reducing the use of anticoccidial drugs.

The present invention is applicable to the field of biopharmaceuticals and provides the use of plerixafor in the preparation of a drug for treating chicken coccidiosis. Also provided is a drug for treating chicken coccidiosis, comprising plerixafor. This invention addresses the serious drug resistance problem currently faced by anticoccidial drugs in the poultry industry by studying and confirming the effectiveness of plerixafor against chicken coccidiosis, providing a new lead compound for the development of anticoccidial drugs.

Developed and provided are: an anticoccidial agent, and a using method thereof, where the anticoccidial agent has an excellent anticoccidial activity and can eliminate or minimize mass outbreak of coccidioses. Thus, provided are: an anticoccidial agent containing, as an active ingredient, a benzimidazole compound represented by General Formula (1), or a salt of the compound, and a method for using the agent. General Formula (1) is expressed as follows:wherein R1 typically represents haloalkyl; X typically represents oxygen; R typically represents alkyl; Y represents halogen; m denotes 0 or 1; Z represents alkyl or halogen; and n denotes 0, 1, or 2.

The invention relates to the technical field of anticoccidial drugs, in particular to an anticoccidial preparation containing nicarbazin and a preparation method of the anticoccidial preparation. The anticoccidial preparation containing nicarbazin comprises the following raw materials in parts by mass: 3-7 parts of nicarbazin, 6-14 parts of monensin, 5-10 parts of mesoporous silica, 1-3 parts of chitosan, 1-2 parts of soybean lecithin, 0.1-0.5 part of carboxyl-terminated polyamidoamine, 1-2 parts of an emulsifier, 1-2 parts of a film-forming agent, 1-3 parts of a dispersant and 20-30 parts of vegetable oil. According to the present invention, the bioavailability is effectively improved, the problem of overhigh or overlow local drug concentration is overcome, the poultry can be prevented from being easily poisoned after ingestion, the treatment effect can be improved, the coccidiosis prevention and treatment effect is significant, the poultry growth is effectively promoted, the production cost is effectively reduced, and the batch production and the large-area promotion are easily achieved.

The invention discloses a compound traditional Chinese medicine and application thereof in preparing a medicine for resisting eimeria tenella or treating coccidiosis, and relates to the technical field of livestock breeding. The compound traditional Chinese medicine comprises the following raw materials in parts by mass: 5-20 parts of hesperidin and 1-10 parts of citric acid. According to the invention, chicks are taken as experimental subjects, a chick coccidiosis model is established, and the effect of the compound traditional Chinese medicine on the chick coccidiosis is researched from the aspects of general conditions of the chicks, bloody stool conditions, coccidiocyst discharge conditions, cecum tissue lesion conditions, pathological detection, serum biochemistry, oxidation resistance detection and the like. The compound traditional Chinese medicine achieves a good anti-coccidiosis drug level, the required raw materials are low in cost, convenient to use and free of hormones and antibiotics, no toxic or side effect is caused to chickens, drug resistance cannot be caused, a new choice is provided for replacing chemical drugs for preventing and treating coccidiosis, and addition of anti-coccidiosis drugs in chicken feed is expected to be reduced or replaced.

The invention discloses a novel halofuginone derivative, a preparation method thereof and application of the halofuginone derivative in anticoccidial drugs, and belongs to the field of veterinary drugs. The compound provided by the invention is based on a halofuginone compound as a lead compound, a halofuginone derivative with a novel structure is designed and synthesized by utilizing a computer-aided drug design technology and a skeleton migration principle, a one-pot synthesis method is adopted, the synthesis process is simple, and the used raw materials are simple, easy to obtain, economical and practical. The anticoccidial index (ACI) of the anticoccidial drug prepared from the derivative provided by the invention can reach 180, and the anticoccidial drug has a good anticoccidial effect.

The invention discloses application of para aminobenzoic acid synthase and / or hydroxymethyl dihydropterin pyrophosphate kinase-dihydropterioic acid synthase in regulation and control of coccidium drug resistance, and through comparative analysis of whole transcriptome level, only in DZR strain, the para aminobenzoic acid synthase and / or hydroxymethyl dihydropterin pyrophosphate kinase-dihydropterioic acid synthase can be used for regulating and controlling coccidium drug resistance. A key rate-limiting enzyme coding gene of a folic acid biosynthetic pathway, namely para aminobenzoic acid synthase (EtpABAS), is specifically associated with the expression level of hydroxymethyl dihydropterin pyrophosphate kinase-dihydropteroic acid synthase (EtHPPK-DHPS), and the drug resistance of diclazuril is specifically associated with the expression level of the hydroxymethyl dihydropterin pyrophosphate kinase-dihydropteroic acid synthase (EtHPPK-DHPS). The invention reveals that the molecular mechanism of E.tenella for generating drug resistance to diclazuril is closely related to the folic acid synthesis pathway for the first time, and defines the core regulation effect of the key metabolic enzyme EtpABAS in the folic acid synthesis pathway in the process. Meanwhile, the invention provides a strategy for intervening generation of the drug resistance of the coccidiosis by regulating and controlling a folic acid metabolic pathway, a new theoretical basis and a new practice direction are provided for research, development and precise medication of novel anti-coccidiosis drugs, and the method has remarkable scientific value and industrial application prospect.

This invention relates to the field of biomedical technology and provides the application of pemetrexed in the preparation of anticoccidial drugs. This invention discloses a novel application of pemetrexed in the preparation of anticoccidial drugs, verifying that the compound has clear anti-parasitic activity in vitro, significantly improves chick survival rate, weight gain, reduces oocyst expulsion, and alleviates cecal lesions in vivo, with an anticoccidial index (ACI) rating of moderate efficacy. Furthermore, it exhibits low cytotoxicity and good safety, providing a new candidate and application direction for anticoccidial drugs.

The present invention relates to an N-(2-oxopropyl)acetamide derivative, its preparation method, and its use. The N-(2-oxopropyl)acetamide derivative has a structure as described in Formula (I), its stereoisomers, or pharmaceutically acceptable salts thereof. The N-(2-oxopropyl)acetamide derivative provided by the present invention has a quinazolinone and its analogue skeleton and exhibits good water solubility, low cytotoxicity, and high in vitro and in vivo anticoccidial and anti-Toxoplasma activity. This addresses the problems of strong drug resistance in existing anticoccidial drugs and the lack of anti-Toxoplasma drugs. #imgabs0#

The invention relates to the technical field of medicines, and discloses application of usnic acid derivatives in preparation of anticoccidial drugs or feed additives. The invention further discloses an anti-coccidiosis medicine containing the usnic acid derivative and a feed additive. The invention provides a novel means for treating and preventing chicken coccidiosis. By adding the usnic acid derivative (especially the usnic acid-7-(4-chlorobenzoate)) into the feed, the chicken coccidiosis resisting effect which is more efficient than that of the same dosage of usnic acid can be achieved, the medication cost is reduced, large-scale popularization is facilitated, and the problem of drug resistance of part of clinical coccidiosis resisting drugs is solved.