58 results about "Anticoccidial Agents" patented technology

The invention relates to a decoquinate nanoemulsion coccidium-resisting drug. The particle size of the decoquinate nanoemulsion coccidium-resisting drug is 1-100nm, the decoquinate nanoemulsion coccidium-resisting drug consists of, by mass percentage, decoquinate 0.1-6.0%, surface active agent 20.0-35.0%, cosurfactant 0-22.0%, cosolvent 1.0-3.0%, oil 1.5-12.0% and the balance distilled water. The drug is light yellow, is clear and transparent liquid visually, has the advantages of being good in stability, low in viscosity, strong in dispersibility, rapid in absorption and the like, and further has slow releasing and targeting effects. The bioavailability of the drug can be improved, half-life period of the drug in the body can be prolonged, and curative effect is enhanced. The decoquinate nanoemulsion coccidium-resisting drug is simple in preparation process, low in energy consumption, small in toxicity and high in safety, and can be produced in a mass mode without requiring special equipment.

The invention discloses an application of secoisolariciresinol diglucoside in preparation of a drug with resistance to eimeria tenella. Powder is prepared from the secoisolariciresinol diglucoside and acceptable auxiliary materials, is added to feed and is mixed uniformly, and chickens are fed according to the daily amount of feed; or water-soluble secoisolariciresinol diglucoside powder is prepared from the secoisolariciresinol diglucoside and dissolved in water, and the chickens are fed according to the daily drinking amount. Animal infection experiments prove that the ACI (anti-coccidial index) of the secoisolariciresinol diglucoside can be up to 165 or higher, and the secoisolariciresinol diglucoside has a better eimeria tenella resistant effect. Compared with a conventional anti-coccidial drug, namely, sulfachloropyrazin, the secoisolariciresinol diglucoside has a remarkable eimeria tenella resistant effect. According to the application of the secoisolariciresinol diglucoside, the problem of severe drug tolerance produced through adoption of the anti-coccidial drug in the current breeding industry can be effectively solved, the research and development speed of a new drug can be increased on the basis, and great benefits are provided for green and healthy development of the breeding industry.

Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidieal agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria. African typanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

The present invention discloses a fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs. The structural formula of the fluoroethyl thiamine or salts thereof is shown as Formula (I). The fluoroethyl thiamine or salts thereof of the present invention have a remarkable anticoccidial effect, particularly on some coccidia which had resistance to other anticoccidial drugs, therefore the fluoroethyl thiamine or salts thereof of the present invention can be applied to preparation of anticoccidial drugs. Thus, the present invention provides conditions for development of new anticoccidial drugs.

The invention discloses a compound solution of toltrazuril and diclazuril and a preparation method and application thereof, belonging to the field of livestock / poultry coccidiosis prevention. The compound solution of toltrazuril and diclazuril, disclosed by the invention, consists of main medicines and an accessory, wherein the main medicines include toltrazuril and diclazuril; preferably the mass ratio of the diclazuril to the toltrazuril is 1:(3-5), and the content of toltrazuril accounts for 2-10% of the solution by mass; the accessory is a compound solvent consisting of ethanol, diethanol amine and propylene glycol; the diethanol amine is a pH regulator which regulates the pH value of the compound solution to 8-10; and the propylene glycol is a diluting solvent. According to the prepared compound solution, the actual use concentration of toltrazuril is greatly reduced, and the cost is lowered; and the detection result also shows that the prepared compound solution is an efficient anticoccidial drug and has good stability.

The invention relates to use of galangin and a derivative thereof in preparing a medicine or a feed for resisting coccidiosis. Compared with the prior art, the galangin and the derivative thereof have an obvious inhibiting effect on eimeria tenella. The inhibiting effect is reflected in that the galangin and the derivative thereof can effectively inhibit reproduction of eimeria tenella on a cell culture model of the eimeria tenella. Besides, the inhibiting effect is verified by an animal body test. Aiming at the discovery of the galangin and the derivative thereof, use fields of the galangin and the derivative thereof are widened, and a new scheme is provided for development of anticoccidial drugs.

The invention belongs to the technical field of coccidium drug-resistant strain induction and acquisition, and particularly relates to a test for rapidly inducing drug-resistant strains in a simulated field and a separation and identification scheme of the drug-resistant strain, which are related to an anticoccidial drug. According to the method for simulating field rapid induction of the anti-coccidiosis drug-resistant strains, by designing two batches of rapid induction drug-resistant strain tests before and after, a plurality of stable drug-resistant strains can be rapidly screened out within 7 weeks, and then a sufficient number of drug-resistant strains can be obtained within a short time. According to the test, under the condition that the original strain background is clear, the coccidium drug-resistant strains can be rapidly screened, high timeliness is achieved, the sample number required by subsequent deep analysis is met, the reliability of the method is verified in the test for screening the drug-resistant strains of the two drugs, and the method has the advantages of being short in consumed time, easy to operate and low in cost and can be widely applied to test induction, screening and identification of chicken coccidiosis drug-resistant strains.

The invention relates to a preparation method of a stable triazinone anticoccidial drug dry suspension. The triazinone anticoccidial drug is uniformly dispersed in a drug auxiliary material and a carrier through optimization of a suspending aid, a surfactant and a dispersing agent, the dry suspension is prepared through an extrusion spheronization process, and the preparation can be uniformly suspended in water according to a certain proportion for animals to drink. All auxiliary materials involved in the invention are easy to obtain, the cost is low, the preparation process is simple, the product quality is stable, the suspension effect in water is good and the like, and compared with a premix and a solution, the clinical application advantages are more obvious.

The invention discloses an anticoccidial adprin preparation, which comprises the following components in percentage by weight: adprin 4-15%, surfactant 5-15%, solvent 55-90%, and deionized water 1-15%. The invention also discloses a preparation method of the anticoccidial adprin preparation. The anticoccidial adprin preparation disclosed by the invention can be mixed with water in any ratio without precipitation, is convenient to use, and reduces administration cost and improves bioavailability and curative effect. The anticoccidial adprin preparation has simple preparation method and good stability, is easy for storage, and has good prospect of application and generalization.