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Stable triazinone anticoccidial drug dry suspension and preparation method thereof

A technology of triazine ketones and dry suspensions, which can be applied in directions such as pharmaceutical combinations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., can solve the problems of complex preparation process and high equipment conditions, and achieve a simple preparation process and high safety. Effect

Inactive Publication Date: 2020-01-24
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The dosage form of "a soluble and stable patopazuril composition and its preparation method (CN103315986A; publication date: September 25, 2013)" is powder, which needs to be heated to 40-60°C during the preparation process. Then spray-dry or freeze-dry, the preparation process is complex and requires high equipment conditions

Method used

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  • Stable triazinone anticoccidial drug dry suspension and preparation method thereof
  • Stable triazinone anticoccidial drug dry suspension and preparation method thereof
  • Stable triazinone anticoccidial drug dry suspension and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0022] Embodiment 1: Triazinone anticoccidial drug dry suspension formulation:

[0023]

[0024]

[0025] Preparation method:

[0026] (1) Weigh Polyethylene Glycol 1200, heat to 60°C, reach a stirrable state, then add 5 kg of Toltrazuril, stir to make it evenly dispersed, and it is Suspension A;

[0027] (2) Put suspension A under high shear at 60°C for 5 minutes, then add it into microcrystalline cellulose, and stir to make a soft material;

[0028] (3) The above-mentioned soft material is granulated by an extrusion spheronizer, and the obtained granules are dried, crushed and passed through a 60-mesh sieve, and the content is measured, and the prescribed amount of anhydrous glucose and lactose is added, mixed evenly, and packaged, that is have to.

Embodiment 2

[0029] Embodiment 2: prescription of triazinone anticoccidial drug dry suspension:

[0030]

[0031] Preparation method:

[0032] (1) Weigh 1 kg of sodium lauryl sulfate, add it to 16 L of 20% ethanol aqueous solution, stir evenly, add Patopazuril 6 kg, stir to make it evenly dispersed, and it is suspension A;

[0033] (2) Suspension A was subjected to high shear for 15 minutes;

[0034] (3) Add the above solution into the maltodextrin and stir to make a soft material;

[0035] (4) The above-mentioned soft material is granulated by an extrusion spheronizer, and the obtained granules are dried, pulverized and passed through a 60-mesh sieve, and the content is measured, added to anhydrous sodium sulfate in the prescribed amount, mixed evenly, and packaged to obtain final product .

Embodiment 3

[0036] Embodiment 3: prescription of triazinone anticoccidial drug dry suspension:

[0037]

[0038] Preparation method:

[0039] (1) Take 20kg Polyethylene Glycol 600, add Patopazuril, stir to obtain mixture A;

[0040] (2) After high-shearing the above solution for 2 minutes, add microcrystalline cellulose and stir to make a soft material;

[0041] (4) The above-mentioned soft material is granulated by an extrusion spheronizer, the obtained granules are dried, crushed and passed through a 60-mesh sieve, the content is measured, added to the prescribed amount of lactose, mixed evenly, and packaged to obtain the product.

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Abstract

The invention relates to a preparation method of a stable triazinone anticoccidial drug dry suspension. The triazinone anticoccidial drug is uniformly dispersed in a drug auxiliary material and a carrier through optimization of a suspending aid, a surfactant and a dispersing agent, the dry suspension is prepared through an extrusion spheronization process, and the preparation can be uniformly suspended in water according to a certain proportion for animals to drink. All auxiliary materials involved in the invention are easy to obtain, the cost is low, the preparation process is simple, the product quality is stable, the suspension effect in water is good and the like, and compared with a premix and a solution, the clinical application advantages are more obvious.

Description

technical field [0001] The invention relates to a formulation and a preparation method of a dry suspension of triazinone anticoccidial drugs. Background technique [0002] Coccidia mostly occur in warm and humid seasons, but under large-scale feeding conditions, chickens and pigs of all ages can be infected with coccidia. Chickens of introduced breeds are more susceptible than local chickens, and yellow chickens and local pigs are more susceptible due to breeding The way and the structural characteristics of the livestock house are the animal groups with a high incidence of coccidia. Chicken coccidiosis mostly occurs in poultry at the age of 15 to 50 days, and chickens over 3 months old are less likely to get sick, and adult chickens generally do not get sick. A kind of intestinal parasitic protozoan disease, which mainly harms piglets aged 7-21 days, and is characterized by diarrhea in piglets, showing symptoms of acute or chronic enteritis. The disease is most likely to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/10A61K47/20A61K47/26A61K31/53A61P3/02
CPCA61K9/1617A61K9/1641A61K31/53A61P3/02
Inventor 刘桂兰栗栖凤夏雪林杨霁菡刘爱玲李守军
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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