Novel application of cynarin

A technology for the application of cynaric acid, which is applied in the field of new applications of cynaric acid, can solve the problems of lack of effective prevention and treatment of coccidiosis, and achieve the effect of broadening the application field

Inactive Publication Date: 2021-06-11
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Based on this, it is necessary to address the lack of effective prevention and treatment of coccidiosis clinically, and provide a new use of cynic acid, specifically the use of cynic acid in the preparation of anti-coccidiosis drugs or feed

Method used

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  • Novel application of cynarin
  • Novel application of cynarin
  • Novel application of cynarin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Experimental materials:

[0058] (1) Drugs: Artichoke acid was purchased from Bailingwei Technology Company, and sulfachlorpyrazine sodium was purchased from Merck Company.

[0059] (2) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0060] (3) Cells: MDBK cells (ie, bovine kidney cells), preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences.

[0061] 2. Experimental method:

[0062] In this embodiment, the E.tenella MDBK cell culture model is used to evaluate the anti-Eimeria tenella (E.tenella) effect, and the specific evaluation steps include:

[0063] (1) Digest the MDBK cells growing to a fusion state of more than 80% with 0.25% trypsin digestion solution, and use 4×10 5 Plate 12-well cell culture plates at the concentration of cells per well and ...

Embodiment 2

[0089] 1. Experimental materials:

[0090] (1) Preparation of cynic acid powder: 5 g of cynic acid (with a content of not less than 80%) and 95 g of starch were mixed to obtain cynic acid powder.

[0091] (2) Control drug: conventional anticoccidial drug Sanzi coccidian powder (30% sodium sulfachlorpyrazine), produced by Shanghai Novartis Animal Health Co., Ltd.

[0092] (3) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0093] (4) Chicks: Lingnan yellow broiler chickens, provided by the Institute of Animal Science, Guangdong Academy of Agricultural Sciences, were raised in a sterilized special animal room; the chicken cages and utensils were strictly sterilized, free to eat and drink pure water; observe before the test Whether the chicks have clinical symptoms and whether there are coccidioides oo...

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Abstract

The invention relates to the technical field of animal disease prevention and control, in particular to a novel application of cynarin, and particularly relates to an application of cynarin in preparation of drugs or feeds for resisting coccidiosis. Compared with the prior art, the invention has the following beneficial effects that cynarin has an obvious inhibition effect on coccidium (especially eimeria tenella), and the inhibition effect is reflected in that the cynarin can effectively inhibit the reproduction of the eimeria tenella on an MDBK cell culture model of the eimeria tenella. Besides, the inhibition effect is verified by animal body tests. With the novel application of cynarin, the application field of cynarin is widened, and a new scheme is provided for development of anticoccidial drugs.

Description

technical field [0001] The invention relates to the technical field of animal disease prevention and control, in particular to a new application of cynic acid. Background technique [0002] Cynic acid (1,3-dicaffeoylquinic acid), also known as cynarin, has a molecular weight of 516.45, a CAS number of 30964-13-7, and a molecular formula of C 25 h 24 o 12 , the chemical structure is as follows: [0003] Artichoke acid exists in the whole plant of Compositae, artichoke (Cynarascolymus L.), forest Senecio (Senecio nemorensis L.), and can also be chemically synthesized. [0004] Existing studies have shown that cynaric acid has free radical scavenging, antioxidant and antiviral effects. According to reports, the functions of cynaric acid include: it can enhance bile and reduce fat, detoxify the liver, and prevent fatty liver; it can effectively inhibit the oxidation of LDL cholesterol and lower cholesterol; it has the effect of protecting the liver and can repair damaged l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P33/10A23K20/111A23K50/75
CPCA61K31/216A23K20/111A23K50/75A61P33/10
Inventor 廖申权孙铭飞戚南山胡俊菁吕敏娜吴彩艳李娟蔡海明林栩慧肖文婉于林增张小慧张健騑谢明权
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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