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Preparation method of compound solution of toltrazuril and diclazuril and application thereof

A technology of toltrazuril and diclazuril, which is applied in the field of preparation of compound solutions, can solve the problems of high price and lack of advantages, and achieve the effects of improving solubility, good stability and reducing the concentration used

Active Publication Date: 2013-09-04
ZHONGSHAN TIANTIAN ANIMAL HEALTH CARE TECHNOLOGICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1985, chlorothiazil (toltrazuril solution) began to enter the Chinese market, and was added to poultry drinking water at a concentration of 25mg / L (calculated as toltrazuril), but because of its high price, it was often used as the last treatment for coccidiosis A line of defense, the product is only used in small numbers in emergencies on breeder farms
The raw material of Toltrazuril has been localized at present, but the price is still relatively expensive, and it lacks advantages compared with other anticoccidial drugs in terms of use and promotion

Method used

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  • Preparation method of compound solution of toltrazuril and diclazuril and application thereof
  • Preparation method of compound solution of toltrazuril and diclazuril and application thereof
  • Preparation method of compound solution of toltrazuril and diclazuril and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of a compound solution of toltrazuril and diclazuril (containing 2.0% by mass of toltrazuril and 0.6% by mass of diclazuril):

[0031] Mix 30g of diethanolamine with 100mL of ethanol, add 6g of diclazuril and 20g of toltrazuril respectively, heat in a water bath to about 55°C to dissolve completely, add propylene glycol to 1.0L, filter with 300-mesh silk cloth, and take an appropriate amount of sample for inspection (see the test method in Example 4), after passing the test, repack according to the required specifications, and obtain the compound solution of toltrazuril and diclazuril.

[0032] Raw material manufacturer: Toltrazuril is produced by Hubei Longxiang Pharmaceutical Co., Ltd., approval number: Veterinary Medicine (2006) 170112053; diclazuril is produced by Zhejiang Guobang Pharmaceutical Co., Ltd., approval number: Veterinary Medicine (2006) ) 110131139.

Embodiment 2

[0034]Preparation of a compound solution of toltrazuril and diclazuril (containing 2.5% by mass of toltrazuril and 0.5% by mass of diclazuril):

[0035] Mix 36g of diethanolamine with 100mL of ethanol, add 5g of diclazuril and 25g of toltrazuril respectively, heat in a water bath to about 55°C to dissolve completely, add propylene glycol to 1.0L, filter with 300-mesh silk cloth, and take an appropriate amount of sample for inspection (see the test method in Example 4), after passing the test, repack according to the required specifications, and obtain the compound solution of toltrazuril and diclazuril.

Embodiment 3

[0037] Preparation of a compound solution of toltrazuril and diclazuril (containing 5.0% by mass of toltrazuril and 1.0% by mass of diclazuril):

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Abstract

The invention discloses a compound solution of toltrazuril and diclazuril and a preparation method and application thereof, belonging to the field of livestock / poultry coccidiosis prevention. The compound solution of toltrazuril and diclazuril, disclosed by the invention, consists of main medicines and an accessory, wherein the main medicines include toltrazuril and diclazuril; preferably the mass ratio of the diclazuril to the toltrazuril is 1:(3-5), and the content of toltrazuril accounts for 2-10% of the solution by mass; the accessory is a compound solvent consisting of ethanol, diethanol amine and propylene glycol; the diethanol amine is a pH regulator which regulates the pH value of the compound solution to 8-10; and the propylene glycol is a diluting solvent. According to the prepared compound solution, the actual use concentration of toltrazuril is greatly reduced, and the cost is lowered; and the detection result also shows that the prepared compound solution is an efficient anticoccidial drug and has good stability.

Description

technical field [0001] The invention belongs to the field of coccidiosis prevention and treatment of livestock and poultry, and in particular relates to a preparation method and application of a compound solution of toltrazuril and diclazuril. Background technique [0002] Coccidiosis is currently a protozoan disease that seriously harms the chicken industry globally and has the highest incidence rate. At this stage, the method of preventing and controlling coccidiosis is still mainly to use anti-balloons in the feed continuously at the susceptible age of chickens. However, billions of chickens still die from coccidiosis every year. Poor feeding conditions, improper use of drugs and drug resistance are the main reasons for this disease. At present, the drugs for the prevention and treatment of chicken coccidiosis in production are roughly divided into two categories: one is polyether ionophore antibiotics, which are produced by fermentation. Generally used for the preventio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K9/08A61P33/02
Inventor 刘雅红沈祥广王慧珍
Owner ZHONGSHAN TIANTIAN ANIMAL HEALTH CARE TECHNOLOGICAL
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