5 results about "Trypanosomiasis" patented technology

The present invention provides diazo compounds having anti-trypanosomal activity, with less or no side-effects. The diazo compounds are structural analogue of quinapyramine and possess characteristics necessary for the targeted pharmacologic action of anti trypanosomosis, with reduced cytotoxicity. The compounds were found to have less cytotoxicity, and identical or better anti- parasitemia effect as compared to conventional quinapyramine sulfate.

The present invention relates to a method for the production of a (poly)hydroxylated pentacyclic triterpene composition including a 3-O-p-coumaroyl ester of tormentic acid from a plant suspension cell culture, to a pharmaceutical composition comprising at least 3-O-p-coumaroyl ester of tormentic acid for a use in the prevention and / or the treatment of trypanosomiasis, optionally in admixture with other (poly)hydroxylated pentacyclic triterpenes, and to 3-O-p-coumaroyl ester of tormentic acid for its use as an antiparasitic agent for the prevention and / or the treatment of trypanosomiasis, optionally in admixture with other (poly)hydroxylated pentacyclic triterpenes.

The invention provides an RPA (recombinase polymerase amplification) detection kit, an RPA-LFD (lateral flow dipstick) detection system and an RPA-LFD detection method. The sequences of an upstream primer and a downstream primer used in the detection are respectively shown as SEQ ID NO. 1 and SEQ ID NO. 2; the sequence of the probe is as shown in SEQ ID NO.3, and tetrahydrofuran is inserted into the probe. The invention further provides a trypanosome RPA (recombinase polymerase amplification) detection kit and a trypanosome RPA-LFD (lateral flow dipstick) detection system containing the detection kit, and also provides a corresponding detection method. The whole detection process can be completed within 23 minutes, the operation is simple and convenient, and the result is visible. Compared with an existing detection method, the method has the advantages of being rapid, sensitive, high in specificity, suitable for on-site operation and the like, and is suitable for early diagnosis and epidemiological investigation of the trypanosomiasis in the large yellow croaker culture process.

The invention discloses a metronidazole compound preparation for treating fish pyramidoniasis and application of the metronidazole compound preparation, and particularly relates to the technical field of parasitic disease prevention and control. The metronidazole compound preparation comprises metronidazole and a Chinese herbal medicine synergistic extract, wherein the Chinese herbal medicine synergistic extract is a mixture of a wormwood extract and a herba artemisiae scopariae extract. Preparing a metronidazole compound preparation: mixing the wormwood extract and the oriental wormwood extract; crushing metronidazole into micro powder; adding water into pharmaceutic adjuvants to prepare a bonding solution; uniformly mixing the extract powder, the metronidazole micro powder, the slow-release carrier and part of the medicinal carrier, spraying a bonding solution, granulating and drying; and uniformly mixing the granules with the residual medicinal carrier to obtain the pharmaceutical composition. According to the metronidazole compound preparation, through the synergistic interaction of the plant source preparation and the metronidazole, the curative effect of the metronidazole in the metronidazole compound preparation is greatly improved, the effective use dosage is reduced, and meanwhile, the metronidazole compound preparation also has the function of assisting in repairing tissue damage caused by infection of a host.

The present invention relates to antisense oligonucleotides that are capable of reducing expression of PD-L1 in a target cell. The oligonucleotides hybridize to PD-L1 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of viral liver infections such as HBV, HCV and HDV; parasite infections such as malaria, toxoplasmosis, leishmaniasis and trypanosomiasis or liver cancer or metastases in the liver using the oligonucleotide.