4 results about "Chagas disease" patented technology

Diagnostic methods, systems, test strips, test kits, and other immunoassay materials are provided for the detection of antibodies to one or more specific parasites of veterinary and human concern in biological samples, including those that are responsible for Chagas disease (Trypanosoma cruzi), Leishmaniasis (Leishmania infantum), and Heartworm (Dirofilaria immitis).

The application relates to fumaric acid cocrystals of N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazol-5-carboxamide (Compound I) and X-ray amorphous complexes of Compound (I) and fumaric acid. The application also provides methods for their preparation; pharmaceutical compositions containing them; and their use in the treatment, prevention, inhibition, improvement, or eradication of the pathology and / or symptoms of a disease caused by a kinetoplastid parasite, such as leishmaniasis, human African trypanosomiasis, and Chagas disease.

The invention provides a modified Trypanosoma cruzi Tc24 polypeptide comprising an amino acid substitution at one or more of amino acid positions: 23, 98, 141, or any combination thereof, relative to the parent Trypanosoma cruzi Tc24 polypeptide. The invention further provides a diagnostic test comprising the modified Trypanosoma cruzi Tc24 polypeptide and a method of diagnosing an individual with Chagas disease using the diagnostic test of claim.

T, cruzi antigens that are useful for detection infection are provided. Methods of detection and various assay formats are also provided.