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Decoquinate nanoemulsion coccidium-resisting drug and preparation method thereof

A technology of decoquinate and anticoccidia, which is applied in the direction of anti-infective drugs, drug combinations, emulsion delivery, etc., can solve the problem that the anti-coccidiostat effect of decoquinate cannot be fully exerted, the particle size cannot meet the requirements, and the utilization It can improve bioavailability, low surface tension and rapid absorption.

Inactive Publication Date: 2012-07-04
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because decoquinate is insoluble in water, the utilization rate is low and the use is wasteful
And studies have shown that as the particle size of decoquinate decreases, its anti-coccidial effect is stronger, but most of the particle sizes of the existing premixes in my country cannot meet the requirements, and the anti-coccidial effect of decoquinate cannot be fully utilized. Coccidian effect

Method used

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  • Decoquinate nanoemulsion coccidium-resisting drug and preparation method thereof
  • Decoquinate nanoemulsion coccidium-resisting drug and preparation method thereof
  • Decoquinate nanoemulsion coccidium-resisting drug and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Embodiment 1 A kind of decoquinate nanoemulsion anticoccidial drug, its raw material ratio is as follows:

[0025] Decoxyquinate 0.03g

[0026] RH-40 9.0g

[0027] Isopropanol 3.0g

[0028] Triethanolamine 1.0g

[0029] IPM 1.0g

[0030] Distilled water 15.0g

[0031] The drug concentration of the above-mentioned decoquinate nanoemulsion is 0.1%; it is prepared by the following method: first get each raw material composition in proportion, then surfactant RH-40, co-surfactant isopropanol and co-solvent three Mix with ethanolamine, then add decoquinate and oil IPM in turn, after mixing, add distilled water dropwise while stirring continuously until a uniform and transparent system is formed, that is, decoquinate nanoparticles with a particle size of 1-100 nm and transparent appearance Milk anticoccidiostats.

Embodiment 2

[0032] Embodiment 2 A kind of decoquinate nanoemulsion anticoccidial drug, its raw material ratio is as follows:

[0033] Decoxyquinate 0.5g

[0034] RH-40 8.0g

[0035] Absolute ethanol 3.5g

[0036] Triethanolamine 0.8g

[0037] Jojoba Oil 0.95g

[0038] Distilled water 16.0g

[0039] The drug concentration of the above-mentioned decoquinate nanoemulsion is 1.7%; its preparation method refers to Example 1, and the prepared decoquinate nanoemulsion anticoccidial drug has a uniform and transparent appearance and a particle size range of 1-100 nm.

Embodiment 3

[0040] Embodiment 3 A kind of decoquinate nanoemulsion anticoccidial drug, its raw material ratio is as follows:

[0041] Decoxyquinate 1.0g

[0042] Tween-80 7.5g

[0043] Isopropanol 3.0g

[0044] Triethanolamine 2.0g

[0045] IPM 1.4g

[0046] Distilled water 15.0g

[0047] The drug concentration of the above-mentioned decoquinate nanoemulsion is 3.3%; its preparation method refers to Example 1, and the prepared decoquinate nanoemulsion anticoccidial drug has a uniform and transparent appearance and a particle size range of 1-100 nm.

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Abstract

The invention relates to a decoquinate nanoemulsion coccidium-resisting drug. The particle size of the decoquinate nanoemulsion coccidium-resisting drug is 1-100nm, the decoquinate nanoemulsion coccidium-resisting drug consists of, by mass percentage, decoquinate 0.1-6.0%, surface active agent 20.0-35.0%, cosurfactant 0-22.0%, cosolvent 1.0-3.0%, oil 1.5-12.0% and the balance distilled water. The drug is light yellow, is clear and transparent liquid visually, has the advantages of being good in stability, low in viscosity, strong in dispersibility, rapid in absorption and the like, and further has slow releasing and targeting effects. The bioavailability of the drug can be improved, half-life period of the drug in the body can be prolonged, and curative effect is enhanced. The decoquinate nanoemulsion coccidium-resisting drug is simple in preparation process, low in energy consumption, small in toxicity and high in safety, and can be produced in a mass mode without requiring special equipment.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, and relates to a new dosage form of veterinary anticoccidial drugs, in particular to a decoquinate nanoemulsion anticoccidial drug and a preparation method thereof. Background technique [0002] Decoquinate (decoquinate) is a very effective quinolone anticoccidiostat for livestock and poultry. It mainly works by inhibiting the development of sporozoites in the early stage and killing early schizonts in the middle stage. The chemical name of Diludine is 2,6-dimethyl-3,5-diethylcarboxylate-1,4-decyloxyquinate, and the molecular formula is C 24 h 35 NO 5 , molecular weight 417.55, very slightly soluble in chloroform or ether, insoluble in water or ethanol; melting point 242-246°C, its chemical structure is as follows: [0003] [0004] As a new type of coccidial drug, decoquinate has been widely used. Practice has proved that decoquinate has excellent anti-coccidial effect and growth-prom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/47A61P33/02
Inventor 胡帅高义
Owner HENAN SOAR VETERINARY PHARMA
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