New use of galangin and derivative thereof

A technology of galangin and derivatives, applied in the direction of medical preparations containing active ingredients, applications, drug combinations, etc., can solve problems such as lack of effective prevention and treatment of coccidiosis

Inactive Publication Date: 2021-07-06
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Based on this, it is necessary to provide a new application of galangin and its derivatives in view of the lack of effective prevention and treatment of coccidiosis in clinical practice. Specifically, galangin and its derivatives are used to prepare anti-coccidiosis drugs or feed Uses in

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  • New use of galangin and derivative thereof
  • New use of galangin and derivative thereof
  • New use of galangin and derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1. Experimental materials

[0060] (1) Galangin and galangin-3-methyl ether were purchased from Bailingwei Technology Company, and sulfachlorpyrazine sodium was purchased from Merck Company.

[0061] (2) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0062] (3) Cells: MDBK cells (ie, bovine kidney cells), preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences.

[0063] 2. Experimental method:

[0064] The E.tenella MDBK cell culture model was used to evaluate the anti-coccidian effect, and the specific evaluation steps included:

[0065] (1) Digest the MDBK cells growing to a fusion state of more than 80% with 0.25% trypsin digestion solution, and use 4×10 5 Plate 12-well cell culture plates at the concentration of cells per well and place at 37°C with 5%...

Embodiment 2

[0093] 1. Experimental materials:

[0094] (1) Preparation of powder form:

[0095] Take 5g galangin (content not less than 80%) and 95g starch and mix respectively to prepare galangin powder;

[0096] Take 5 g of galangin-3-methyl ether and 95 g of starch and mix well to prepare galangin-3-methyl ether powder.

[0097] (2) Control drug: conventional anticoccidial drug Sanzi coccidian powder (30% sodium sulfachlorpyrazine), produced by Shanghai Novartis Animal Health Co., Ltd.

[0098] (3) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0099] (4) Chicks: Lingnan yellow broiler chickens, provided by the Institute of Animal Science, Guangdong Academy of Agricultural Sciences, were raised in a sterilized special animal room; the chicken cages and utensils were strictly sterilized, free to eat and d...

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Abstract

The invention relates to use of galangin and a derivative thereof in preparing a medicine or a feed for resisting coccidiosis. Compared with the prior art, the galangin and the derivative thereof have an obvious inhibiting effect on eimeria tenella. The inhibiting effect is reflected in that the galangin and the derivative thereof can effectively inhibit reproduction of eimeria tenella on a cell culture model of the eimeria tenella. Besides, the inhibiting effect is verified by an animal body test. Aiming at the discovery of the galangin and the derivative thereof, use fields of the galangin and the derivative thereof are widened, and a new scheme is provided for development of anticoccidial drugs.

Description

technical field [0001] The invention relates to the technical field of animal disease prevention and control, in particular to a new application of galangin and its derivatives. Background technique [0002] Galangin (Galangin), is a natural flavonoid alcohol compound extracted from galangal, aliased as galangin, 3,5,7-trihydroxyflavone, molecular formula is C 15 h 10 o 5 , the molecular weight is 270.24, the CAS number is 548-83-4, and the chemical structure is shown in the following formula: [0003] Existing studies have shown that galangin has antioxidant, analgesic, anti-inflammatory, antibacterial and antitumor effects. Galangin-3-methyl ether is a derivative of galangin, the molecular formula is C 16 h 12 o 5 , the molecular weight is 284.26, the CAS number is 6665-74-3, and the chemical structure is shown in the following formula: [0004] According to reports, galangin-3-methyl ether has antibacterial activity and can inhibit pancreatic lipase. [0005] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/14A61K9/08A61K9/50A61P33/02A23K20/121A23K50/75
CPCA61K9/08A61K9/14A61K9/50A61K31/352A23K20/121A23K50/75A61P33/02
Inventor 廖申权孙铭飞戚南山胡俊菁吕敏娜吴彩艳李娟蔡海明林栩慧肖文婉于林增张小慧张健騑谢明权
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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