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Dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis, pruritus or combinations of same

A technology for atopic dermatitis and composition, which is applied in the field of pharmaceutical composition, and can solve problems such as ineffectiveness against skin diseases and side effects

Inactive Publication Date: 2011-07-13
伊格纳西奥安贝尔特米列特
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, in dermatology, it seems to be considered that combinations of active ingredients are generally not effective against skin diseases
[0006] Therefore, in dermatology, preparations against inflammatory diseases are based on the highly effective action of anti-inflammatory agents, corticosteroids alone or in combination with e.g. doxepin (see e.g. CN1363276), however they also have side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1: Anti-inflammatory preparation family (psoriasis, vitiligo, alopecia areata)

[0071] A) Shared active ingredients (formulation backbone)

[0072] -Adrenocorticotropic hormone:

[0073] - Clobetasol Propionate...0.05% (high potency)

[0074] -Indomethacin...1-3% (anti-inflammatory)

[0075] - Pentoxifylline ... 1-3% (antiproliferative)

[0076] - Antioxidants (combination as follows):

[0077] -Lipoic acid...3-5%

[0078] - Quercetin ... 0.1-5%

[0079] -Green tea catechins...0.5%

[0080] - Curcumin ... 1%

[0081] - Ascorbyl palmitate ... 5%

[0082] - Coenzyme Q10...0.3%

[0083] - Resveratrol ... 1%

[0084] -Pycnogenol ...1%

[0085] -L-Carnosine...2%

[0086] - Taurine ... 0.5%

[0087] -Isoflavones...5%

[0088] - Lycopene ... 1%

[0089] -Papaya Extract...Q.s.

[0090] -Other antioxidants

[0091] - Excipient: Base Beeler 、Orabase , water-alcoholic solution

[0092] B) Additional Active Ingredients

[0093] - Emollients:

[00...

Embodiment 2

[0106] Embodiment 2: maintenance preparation family (psoriasis, vitiligo, alopecia areata)

[0107] A) Shared active ingredients (formulation backbone)

[0108] -Indomethacin...1-3% (anti-inflammatory)

[0109] - Pentoxifylline ... 1-3% (antiproliferative)

[0110] - Antioxidants (combination as follows):

[0111] -Lipoic acid...3-5%

[0112] - Quercetin ... 0.1-5%

[0113] -Green tea catechins...0.5%

[0114] - Curcumin ... 1%

[0115] - Ascorbyl palmitate ... 5%

[0116] - Coenzyme Q10...0.3%

[0117] - Resveratrol ... 1%

[0118] -Pycnogenol ...1%

[0119] -L-Carnosine...2%

[0120] - Taurine ... 0.5%

[0121] -Isoflavones...5%

[0122] - Lycopene ... 1%

[0123] -Other antioxidants

[0124] - Excipient: Base Beeper 、Orabase , water-alcoholic solution

[0125] B) Supplementary Active Ingredients

[0126] - Emollients:

[0127] - Glycerin...5-15%

[0128] -Aloe...5-15%

[0129] -Propylene glycol...5-20%

[0130] -Lactic acid...5-12%

[0131] -omega...

Embodiment 3

[0139] Example 3: Family of anti-inflammatory agents (atopic dermatitis or eczema)

[0140] A) Shared active ingredients (formulation backbone)

[0141] -Adrenocorticotropic hormone:

[0142] - Triamcinolone acetonide...0.1% (intermediate effect)

[0143] - Hydrocortisone ... 1% (low potency)

[0144] -Indomethacin...1-3% (anti-inflammatory)

[0145] - Pentoxifylline ... 1-3% (antiproliferative)

[0146] - Antioxidants (combination as follows):

[0147] -Lipoic acid...3-5%

[0148] - Quercetin ... 0.1-5%

[0149] -Green tea catechins...0.5%

[0150] - Curcumin ... 1%

[0151] - Ascorbyl palmitate ... 5%

[0152] - Coenzyme Q10...0.3%

[0153] - Resveratrol ... 1%

[0154] -Pycnogenol ...1%

[0155] -L-Carnosine...2%

[0156] - Taurine ... 0.5%

[0157] -Isoflavones...5%

[0158] - Lycopene ... 1%

[0159] -Vitamin E...1%

[0160] - Excipient: Base Beeper

[0161] B) Additional Active Ingredients

[0162] - Emollients:

[0163] - Glycerin...5-15%

[016...

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PUM

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Abstract

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a basic anti-inflammatory agent, such as indometacin; one or more optional active principles selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol TM , L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR- gamma) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF- alpha) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating skin inflammatory diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis, pruritus and combinations thereof, the pharmaceutical composition comprising at least one main antibody Inflammatory agents, such as indomethacin. Background technique [0002] In dermatology, there are many kinds of neurogenic inflammatory diseases that are common today. These diseases can be dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus, etc. According to immunological changes, gene activation, infection, the destruction of melanocytes and the destruction of hair follicle immune privilege mechanism (immunoprivilege) occur. [0003] A variety of medications are currently used to treat each of these conditions, relying primarily on the use of topical anti-inflammatory agents such as indomethacin, ibuprofen (albeit very photosensitive), ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P17/00
CPCA61K31/12A61K45/06A61K31/355A61K36/82A61K31/405A61K31/385A61K31/375A61K31/122A61P17/00A61P17/02A61P17/04A61P17/06A61P17/10A61P17/14A61P29/00A61P31/00A61P31/10A61P37/08A61P39/06A61P43/00A61K2300/00
Inventor 伊格纳西奥·安贝尔特·米列特
Owner 伊格纳西奥安贝尔特米列特
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