85 results about "Ceramide np" patented technology

The invention belongs to the technical field of cosmetics, and discloses skin-tightening and anti-wrinkle essence. The skin-tightening anti-wrinkle essence is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of acetyl hexapeptide-8, 2.0 to 3.0 percent of palmitoyl pentapeptide-4, 3.0 percent of hydroxypropyl tetrahydropyrantriol, 2.0 percent of lipidosome-coated vitamin C ethyl ether, 0.5 percent of resveratrol PLGA microspheres, 0.8 percent of ceramide NP, 1.2 percent of pachymaran, 5.0 percent of glyceryl polyether-26, 0.3 percent of sodium hyaluronate, 0.5 percent of p-hydroxyacetophenone and 1, 3-propanediol, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate and the balance of water. The 1, 2-hexanediol accounts for 0.6%, and the balance is deionized water. Multi-target anti-wrinkle, deep moisturizing and long-acting repairing are achieved by scientifically compounding active ingredients such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4 and combining a lipidosome wrapping technology and a nano-microsphere slow release technology, the preparation process comprises the steps of lipidosome homogenization, nano-microsphere multiple emulsion method and low-temperature emulsification, the ingredient stability and transdermal efficiency are ensured, and the skin care effect is good. Experiments prove that the essence can significantly improve skin elasticity and reduce wrinkles, and has a significant anti-aging effect.

The invention belongs to the technical field of stem cell biological preparations, and particularly relates to an anti-aging compound preparation based on stem cells and application of the anti-aging compound preparation in delaying skin aging. The composition is composed of an inner water phase, a middle oil phase and an outer water phase, wherein the inner water phase is prepared from the following components: stem cell exosomes, hyaluronic acid, nicotinamide ribose, trehalose, mannitol, glycine and a citric acid buffer solution; the medium oil phase is prepared from the following components: medium chain triglyceride, shea butter, vitamin E succinate, PEG (Polyethylene Glycol) modified ceramide NP and cholesterol succinic acid monoester; the external water phase is prepared from the following components: polydatin, cellulose nanocrystals and an emulsifying agent. On the basis of a W / O / W emulsion system, a multi-layer anti-aging mechanism is constructed by utilizing a three-dimensional delivery framework of an inner water phase, an oil phase and an outer water phase and space-time synergy of active ingredients, the exosome permeation efficiency is improved through microneedle introduction, and the anti-oxidation and barrier repair effects are achieved by using multiple ingredients.

The invention discloses a method for synthesizing ceramide NP through two-step enzyme catalysis, which comprises the following steps of: firstly, adding lipase into vegetable oil to catalyze and combine fatty acid to decompose into free fatty acid, and centrifuging to remove the lipase; a small amount of phytosphingosine is added into the hydrolyzed vegetable oil, the raw material vegetable oil is used as a solvent or a squalane system solvent for incubation, and then immobilized lipase is added for catalytic synthesis of ceramide. The invention establishes a two-enzyme method for efficiently synthesizing the ceramide NP compound, and the process is natural, environment-friendly and non-toxic. The reaction conditions are optimized through response surface analysis, meanwhile, the immobilized lipase shows excellent cycle performance, and the method is easy to operate, environmentally friendly, green and economical and has wide application prospects in the fields of cosmetics, health care products, biological medicine and the like.

The invention relates to an anti-wrinkle and anti-aging composition and application thereof. The anti-wrinkle and anti-aging composition is prepared from hydrolyzed rice protein, a bifidus yeast fermentation product lysate, dipeptide diaminobutyryl benzyl amide diacetate, adenosine, hydroxydecyl ubiquinone, ceramide NP, palmitoyl tripeptide-5, carnosine and acetyl hexapeptide-8. According to the present invention, the components achieve the synergistic effect, such that the fibroblast proliferation can be promoted, the cell metabolism can be improved, the generation of collagen, elastin and the like can be promoted, the excellent oxidation resistance can be provided, and the effects of expression line inhibition, existing wrinkle fading and long-term aging resistance can be combined.

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention belongs to the technical field of biological medicines, and particularly relates to a royal jelly acid derivative and a synthesis method, a pharmaceutical composition and application thereof. The royal jelly acid derivative is a compound shown as a formula (I), or an enantiomer, a diastereoisomer and a tautomer thereof, or a solvate or a pharmaceutically acceptable salt thereof. A series of royal jelly acid derivatives with novel structures are constructed by using a natural component royal jelly acid derived from royal jelly as an initial raw material, the royal jelly acid derivatives can play a role in resisting pulmonary fibrosis by inhibiting the activity of fibroblasts, the effect of the royal jelly acid derivatives is equivalent to that of pirfenidone, and the royal jelly acid derivatives are expected to be developed into candidate drugs for resisting pulmonary fibrosis. The ceramide NP has excellent effects in anti-inflammatory, anti-allergic and itching-relieving aspects, has a better effect than known ceramide NP, and can be used for preparing health care products, cosmetics and medicines. And # imgabs0 #.

The invention discloses a wet tissue liquid for improving hemorrhoid symptoms, a wet tissue, a production method and application, the wet tissue liquid comprises asiaticoside, a sophora flower charcoal extract, bisabolol, a honeysuckle flower extract, a rosemary extract, ceramide NP, D-panthenol, potassium cocoyl glycinate, citric acid, sodium citrate and purified water, and the wet tissue comprises spunlace non-woven fabric. The wet tissue liquid is loaded on a non-woven fabric, the production process of the wet tissue liquid comprises a pretreatment stage, a preparation stage and a filtering stage, and the produced wet tissue liquid is applied to hygienic products for improving hemorrhoid symptoms. The sophora flower charcoal extract is used for the haemorrhoids wet tissue liquid to achieve the effects of stopping bleeding, cleaning and mildly easing pain; double natural extracts are compounded to replace preservatives, traditional single symptom relief is upgraded to symptom treatment, mucous membrane repair and barrier protection, disease deterioration and recurrence risks are reduced, and the composition is free of chemical preservatives, free of irritant surface activity and suitable for being used by people with hemorrhoid symptoms.

The invention provides a liquid crystal bionic water-locking and oxygen-permeating nursing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The skin care product is prepared from components in percentage by weight as follows: 20%-40% of glycerin, 5%-10% of hydrogenated lecithin, 5%-10% of phytosterols, 0.1%-0.5% of sodium stearoyl glutamate, 0.01%-0.05% of sodium methyl stearoyl taurate, 0.1%-1% of ceramide NP, 1%-10% of caprylic / capric triglyceride, 1%-10% of squalane, 0.1%-1% of tocopheryl acetate, 0.01%-0.3% of DNA sodium, 0.001%-0.1% of fibronectin and the balance of water. 0.001-0.1% of soluble collagen and the balance of water. The liquid crystal bionic water-locking and oxygen-permeating nursing composition provided by the invention can better form a breathable protective film on the surface of skin, reduce water loss of the skin and help to repair a damaged skin barrier, so that the water-locking and oxygen-permeating nursing effect is achieved.

The invention belongs to the field of cosmetics, and particularly discloses a stable soothing anti-aging cosmetic composition as well as a preparation method and application thereof. The cosmetic composition comprises a phase A, a phase B, a phase C and a phase D, the phase A comprises an emollient and a powder dispersant; the phase B comprises an emollient and an active component; the phase C comprises a thickening agent, an emulsifying agent, an emollient, a film-forming agent and a skin feeling conditioning agent; the phase D comprises water, a humectant, an antioxidant, an anti-freezing agent and a thickening agent; the active ingredients comprise at least one of phytosphingosine, ceramide NP, batyl alcohol, a glycyrrhiza inflate extract and licochalcone A. The invention further discloses a preparation method of the pharmaceutical composition. The cosmetic composition is good in stability and good in moisturizing, soothing and anti-aging effects, and has an unexpected synergistic technical effect.

The application provides a formula system and a preparation method for improving the solubility and stability of ceramide NP, and belongs to the cosmetic field.The formula system comprises: an active ingredient, an emulsifier, a thickening agent and a solvent; the active ingredient is ceramide NP; the emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a non-ionic emulsifier and a phospholipid emulsifier; and the solvent comprises water, a polyhydric alcohol and an oil-soluble solvent.The formula system has an unexpected technical effect of greatly improving the stability of an oil-in-water cosmetic containing more ceramide NP by selecting suitable emulsifiers, thickening agents and solvents.

The invention discloses an anti-aging and anti-allergy spray suitable for pregnant women based on micro-ecology-barrier-immune synergistic repair and a preparation method of the anti-aging and anti-allergy spray. The spray is prepared from 2.00 percent to 4.00 percent of hydrolyzed quinoa protein, 1.00 percent to 5.00 percent of lactobacillus / soybean milk fermentation filtrate, 0.30 percent to 1.00 percent of radix stellariae extract, 0.20 percent to 1.50 percent of perilla leaf extract, 0.01 percent to 0.50 percent of three-layer liposome tetrahydrocurcumin, 1.00 percent to 10.00 percent of Tibetan plateau freeze-dried tricholoma matsutake extracting solution, an active peptide combination and a ceramide compound. According to a quadruple synergistic mechanism, (1) the pH value of the fermentation filtrate is adjusted to 5.3, and the fermentation filtrate and the hydrolyzed quinoa extract synergistically construct a micro-ecological foundation; (2) repairing the barrier by ceramide NP, cholesterol, phytosphingosine and the like; (3) multiple anti-allergy effects of radices stellariae dichotomae, purple perilla, asiaticoside and dipotassium glycyrrhizinate; and (4) liposome curcumin, glabridin liposome and active peptide cooperate to resist aging, and a'micro-ecological balance-barrier reconstruction-immunosuppression-targeted anti-aging 'quadruple synergistic effect system is constructed. The preparation method comprises the steps of A-phase / B-phase preparation, emulsification, active addition and sterile filling, and the skin requirements in the pregnancy period and the lactation period are met.

The invention discloses an efficient water-locking repair mask and a preparation method thereof, and belongs to the technical field of cosmetics, the efficient water-locking repair mask comprises the following components by mass: 0.5-2.0% of an astragalus membranacus extract fermentation broth, 0.1-0.5% of ceramide NP, 0.05-0.3% of a sodium hyaluronate composition, 0.1-0.3% of polyquaternium-51, 1-3% of a lactobacillus plantarum fermentation lysate, 1-5% of ethanol, and the balance of deionized water. The lactobacillus plantarum fermentation lysate comprises propionic acid and butyric acid. The Astragalus membranacus extract fermentation broth can remove allergic components and form a lipid-polysaccharide interpenetrating network with ceramide NP, and the Astragalus membranacus extract fermentation broth and ceramide NP synergistically simulate a natural barrier structure of skin, so that the order degree of cuticle lipid is improved, transdermal moisture loss is prevented, and the repairing and water locking functions are remarkably enhanced; butyric acid and propionic acid in the lactobacillus plantarum fermentation lysate promote penetration of ceramide NP by acidifying a cuticle microenvironment (pH 4.5), and the biological safety is high.

The application belongs to the technical field of anti-aging skin care product preparation, and discloses a composition containing a composite exosome-polypeptide, a preparation method thereof and application of the composition in cosmetics. The composition contains, in terms of mass fraction, 3.0%-7.0% of an exosome-polypeptide composite wrapped by a biomimetic liposome, 4%-9% of a plant active synergistic extract, 15%-20% of a temperature-sensitive moisturizing sustained-release system, 3%-6% of a lipid barrier repair agent, 0.3%-0.8% of an antioxidant stabilizer, and the rest is a basic base; the exosome is composed of membrane pod huangqi root exosome, salvia miltiorrhiza exosome and long life flower exosome; the polypeptide is composed of palmitoyl tripeptide-5 and acetyl hexapeptide-8; and the biomimetic liposome is composed of phosphatidylcholine, ceramide NP and phytosteryl oleate. The application is compounded by the composite exosome-polypeptide-multiple effect component, hierarchical synergy is achieved, multiple-dimensional aging targets are covered, the transdermal rate is improved, the activity is retained for a long time, the barrier repair and skin quality adaptation are considered, and the anti-aging performance is excellent.

The invention provides a whitening composition containing a jasmine extract as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The whitening composition is prepared from the following components in parts by weight: 1 to 10 parts of nicotinamide; 0.1 to 5 parts of taurine; 0.1 to 3 parts of lecithin; 0.01 to 2 parts of inositol; 0.01 to 1 part of ceramide NP; 0.1 to 3 parts of tranexamic acid; 0.01-2 parts of glutathione, 0.1-5 parts of a jasmine flower lactobacillus fermentation extract and 20-60 parts of water. By controlling the types and mass ratio of the specific components, especially the mass ratio of lecithin to tranexamic acid, inositol to glutathione, and nicotinamide to taurine to jasmine lactic acid bacteria fermentation extract, the obtained composition not only can inhibit melanin generation and transport, but also can promote permeation of effective components, so that the anti-aging effect of the composition is improved, and the anti-aging effect of the composition is improved. The content of effective components in the skin is increased, so that the absorption effect and the bioavailability of the product are improved.

The invention relates to the field of lipidosome technology and skin external preparations, in particular to bionic ceramide coated retinol lipidosome and a preparation method and application of the bionic ceramide coated retinol lipidosome. The liposome is prepared from the following raw materials in parts by weight: 1.0 to 3.0 weight percent of ceramide NP, 1.0 to 3.0 weight percent of ceramide AP, 0.05 to 0.5 weight percent of ceramide EOP, 1.0 to 3.0 weight percent of cholesterol, 0.50 to 2.0 weight percent of meadowfoam seed oil, 3.0 to 10.0 weight percent of hydrogenated lecithin, 1.0 to 3.0 weight percent of retinol, 0.50 to 2.50 weight percent of tocopheryl acetate, 15.0 to 45.0 weight percent of caprylic / capric triglyceride MCT, 1.0 to 5.0 weight percent of propylene glycol, 15.0 to 45.0 weight percent of glycerol and the balance of water, the bionic layered film is constructed by the multi-subtype ceramide, cholesterol and hydrogenated lecithin, the oil phase and an antioxidant system are cooperated, the stability of retinol under light, heat and oxygen is remarkably improved, slow release is achieved, meanwhile, skin tolerance is improved, and the bionic layered film can be widely applied to essence, emulsion, face cream, ampoule and other external skin care preparations.

The invention discloses an anti-allergy face cream containing a beta-sitosterol nano-composite and a preparation method of the anti-allergy face cream, and belongs to the technical field of cosmetics. Comprising the following components in percentage by mass: 3%-10% of a purified astragalus membranacus extract-beta-sitosterol nano complex, 1.65%-4.2% of a lipid complex, 0.5%-1% of bisabolol, 2%-4% of a natural emulsifier, 0.2% of a pH regulator, 6%-10% of grease and the balance of deionized water. The lipid complex comprises ceramide NP and cholesterol. The nano-complex is of a core-shell structure, the stability of beta-sitosterol can be improved, pH response type slow release of beta-sitosterol is achieved, systematic repair of sensitive skin can be achieved by regulating and controlling the inflammation-nerve dual-channel activity and optimizing the transdermal delivery mechanism, a dual-phase delivery system of the lipid complex and the nano-complex has a good application prospect, and the application prospect is wide. A compact physical repair barrier is formed, and a compact layered membrane structure is reconstructed to reduce trans-epidermal moisture loss.

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

The application belongs to the technical field of skin care product preparation, and discloses an alcohol-in-oil microcapsule bead and a method for preparing the same by using microfluidic technology and application of the same. The alcohol-in-oil microcapsule bead comprises a shell and a core material, the shell is formed by solidification of an oil phase solution, and the core material is composed of an alcohol phase solution; the oil phase solution is composed of an oil phase film material, an oil phase solvent and an oil phase active substance, the oil phase film material is composed of HDI / trimethylol hexyl lactone cross-linked polymer and castor oil / IPDI copolymer, the oil phase solvent is composed of squalane, white pool flower seed oil and diisostearyl malate, and the oil phase active substance is composed of ascorbic acid tetraisopalmitate, tocopherol and ceramide NP; the alcohol phase solution is composed of an alcohol phase solvent and an alcohol phase active substance, the alcohol phase solvent is butanediol, and the alcohol phase active substance is Ampelopsis aconitifolia extract.

This invention discloses a soothing and repairing composition and its application, comprising the following raw materials: phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, tocopherol, ceramide NP, triethanolamine, lactobacillus, macadamia seed oil, magnolia alcohol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, inulin root juice, arginine / lysine polypeptide, squalane, jojoba seed oil, scutellaria baicalensis root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylate / C10-30 alkanol acrylate crosspolymer, α-glucan oligosaccharide, 1,2-hexanediol, and water as the balance. Compared with the prior art, the soothing and repairing composition prepared by this invention has the effects of rapidly rebuilding the skin barrier, regulating skin immune function, improving skin microecology, synergistic effect, and rapid skin repair.

The invention discloses a composition with a skin barrier repairing effect as well as a preparation method and application thereof. The composition comprises carboxymethyl chitosan, ceramide and a centella asiatica extract, the mass ratio of the carboxymethyl chitosan to the ceramide to the centella asiatica extract is (0.01-5): (0.01-5): (0.01-5). The centella asiatica extract comprises one or a combination of more of madecassic acid, a centella asiatica root extract, asiaticoside and madecassoside, and the ceramide comprises one or a combination of more of ceramide NP, ceramide EOP, ceramide AS, ceramide AP, ceramide NS and ceramide NG. By implementing the invention, the skin barrier can be effectively repaired, the sensitivity can be relieved, and the moisturizing and nourishing effects can be realized.

Provided are a skin care active substance and a skin care product. The skin care active substance comprises, in parts by weight, at least two of 0.0001-12 parts of an antioxidant, 0.05-0.4 parts of a moisturizing and firming agent, 0.05-2 parts of a soothing and anti-irritant agent, and 0.1-15 parts of a moisturizing agent, wherein the antioxidant comprises at least one of ergothioneine, coenzyme Q10, a VC derivative, and a VE derivative; the moisturizing and firming agent comprises at least one of hydrolyzed lupine protein and type XVII collagen; the soothing and anti-irritant agent comprises a peony root extract; and the moisturizing agent comprises at least one of ceramide NP, hydrolyzed sodium hyaluronate, and sodium hyaluronate. By means of designing the described components and their ratios, the synergistically formed active substance improves the skin condition and exhibits high safety.

The invention relates to a light and thin moisturizing lip cream and a preparation method thereof, and belongs to the technical field of cosmetics. The light and thin moistening type lip cream is prepared from the following raw materials: meadowfoam seed oil, ceramide NP, lecithin, caprylic acid / capric triglyceride, a dendrobium officinale-tremella-glucan compound, tetrahydromethylpyrimidine carboxylic acid, 1, 3-propylene glycol, inulin, a cooling agent WS-23, vitamin E, capryloyl hydroximic acid, ethylhexylglycerin and deionized water. The prepared lip cream provides bionic barrier repair by virtue of ceramide NP wrapped by nano-liposome, has strong water locking effect of a dendrobium officinale-tremella-glucan compound, and is compounded with other components such as meadowfoam seed oil, so that multiple moisturizing repair is provided under the condition that the texture is kept light and thin.

This invention provides a liquid crystal biomimetic water-locking and oxygen-permeable skincare composition, its preparation method, and its application, belonging to the field of cosmetic technology. It comprises the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The liquid crystal biomimetic water-locking and oxygen-permeable skincare composition provided by this invention can better form a breathable protective film on the skin surface, reduce skin moisture loss, and help repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable skincare.

The invention relates to the technical field of cosmetics, in particular to a soothing composition as well as a preparation method and application thereof. The soothing composition is prepared from the following components in percentage by mass: 10 to 20 percent of polyglycerol-10 laurate and other emulsifiers, 10 to 20 percent of palmitamide MEA, 5 to 15 percent of acetamide MEA, 2 to 8 percent of stearyl glycyrrhetinate, 5 to 15 percent of squalane and 0.5 to 2 percent of ceramide NP. The invention also provides a preparation method of the soothing composition, and the soothing composition is quick and long-acting in soothing effect, and can synchronously improve the barrier, anti-inflammatory and moisturizing effects.

The utility model discloses a sampling observation device for ceramide NP preparation, and relates to the field of ceramide NP preparation. The sampling observation device comprises an extraction tube, one end of the extraction tube is provided with a first rubber ring, the inner wall of the first rubber ring is provided with an extraction head, and the inner wall of the extraction tube is provided with a transparent plate. According to the utility model, the connecting frame is arranged to play a connecting role on the magnifying lens, so that when the device is used, the arrangement operation process of the connecting frame and the magnifying lens is simple and convenient, an extract does not need to be transferred from the sampling device to a microscope, and the loss or pollution of a sample is avoided. When the device is used, magnified observation can be easily achieved, time and energy are saved, the quantitative sleeve is subjected to threaded adjustment through the arranged scalar rod, and when the device is used, the volume of sucked ceramide NP extract can be accurately controlled through the arrangement of the scalar rod and the quantitative sleeve. Therefore, the sampling quantity of each time is highly consistent, and the accuracy and repeatability of subsequent analysis and experiment results are ensured.

The invention belongs to the field of skin care materials, and provides a bionic cuticle moisturizing barrier composition and a preparation method thereof. Sodium pyrrolidone carboxylate, an amino acid compound, bimodal molecular weight sodium hyaluronate, trehalose and betaine are used as water-phase humectants, squalane, caprylic / capric triglyceride and phytosterol oleate are used as oil-phase carriers, and cholesterol, hydrogenated lecithin, octyldodecanol and ceramide NP are used as sebum-like barrier components. A layered liquid crystal and alpha gel double-network structure is constructed through a segmented phase inversion emulsification and microjet homogenization process, and a narrow distribution system with the emulsification drop diameter D50 being 0.3-5 microns and SPAN being not larger than 1.2 is achieved. The technical problems that a high-density barrier, ventilation and refreshing are difficult to obtain at the same time, rheological unbalance of a high-solid-content system is caused, and irritation and phase structure damage are caused by traditional high-energy homogenization are solved, and the application value in sensitive skin and barrier damaged skin care is achieved.

This invention discloses a repair composition containing multiple ceramides and its preparation method, belonging to the field of cosmetic technology. The repair composition, by mass parts, comprises ceramide AP, ceramide EOP, ceramide NP, phytosphingosine, Centella asiatica extract, Portulaca oleracea extract, Hydrangea macrophylla extract, ectoine, and tripeptide-1. This invention utilizes multiple ceramides and phytosphingosine to biomimetically replenish the lipids of the stratum corneum, combined with the synergistic effects of various plant active ingredients and active peptides, to effectively achieve multiple effects such as skin barrier repair, soothing and anti-inflammatory properties, and anti-allergy. This invention also provides a barrier repair serum containing this repair composition and its preparation method. The serum has stable physicochemical properties and, verified by in vitro cell experiments and human efficacy tests, can rapidly repair damaged skin barriers, improve sensitive symptoms such as redness and stinging, and is gentle and non-irritating, suitable for daily skincare use by people with sensitive skin and damaged skin barriers.

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

The invention discloses a method for synthesizing retinoic acid ceramide ester through enzyme catalysis and application of the retinoic acid ceramide ester, and belongs to the technical field of cosmetic raw material synthesis. According to the method, retinoic acid and ceramide NP serve as substrates, specific immobilized lipase serves as a catalyst, and in a non-aqueous phase organic solvent, the target product is efficiently synthesized through the steps of raw material preparation, anaerobic reaction system building, directional esterification reaction, aftertreatment and purification detection. The method solves the problems of low substrate solubility, more byproducts, difficulty in catalyst recovery and the like in the traditional process, has the advantages of mild reaction conditions, capability of retaining the activity of the raw materials, high product purity and anti-aging and barrier repair effects, and can be widely used for preparing raw materials of anti-wrinkle and repair cosmetics.

Provided are a skin care active substance and a skin care product. The skin care active substance comprises, in part by weight: 0.1-15 parts of a humectant and 0.05-2 parts of a soothing / antiallergic agent. The humectant comprises at least two of ceramide NP, hydrolyzed sodium hyaluronate, and sodium hyaluronate. The soothing / antiallergic agent comprises a paeonia root extract. By designing the above ingredients and the proportion thereof, the formed synergistic active substance can achieve moisturizing and soothing effects mildly and efficiently, protect the skin barrier effectively, and keep the health of the skin with good safety.