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Cetirizine pseudoephedrine sustained-release capsules

A technology of pseudoephedrine and cetirizine, which is applied in the field of new sustained-release capsule preparations and sustained-release capsule preparations, can solve the problems of complex process, high equipment requirements, and high cost of tablets, and achieves high finished product yield and low equipment requirements. , the effect of simple process

Inactive Publication Date: 2008-05-21
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation process of this double-layer tablet, the process is relatively complicated and the requirements for equipment are relatively high.
The preparation of double-layer tablets requires at least two compressions. In this case, the tablet has to be compressed twice, which may cause the tablet to be compressed too tightly and not easy to disintegrate and release. The molding yield in the preparation is relatively low, and the tablet is expensive more
Chinese patent CN1206991C discloses a cetirizine hydrochloride pseudoephedrine double-layer tablet, and its technical feature is that the pseudoephedrine hydrochloride is pressed into the inner layer core of the slow-release tablet and then the cetirizine quick-release outer layer tablet is pressed on the sustained-release tablet core , when this dosage form disintegrates, the disintegration of the inner sustained-release tablet is affected by the outer immediate-release tablet. When the outer immediate-release tablet disintegrates incompletely, the disintegration speed of the inner sustained-release tablet will inevitably Incomplete; and the disintegration process of the double-layer tablet with this technical feature is that the drug in the inner sustained-release tablet can be released slowly after the outer tablet disintegrates first, which cannot achieve the purpose of releasing the drug at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Preparation of Cetirizine Immediate Release Tablets

[0040] prescription

[0041] Cetirizine Hydrochloride 5g

[0042] Lactose 120g

[0043] Microcrystalline Cellulose 40g

[0044] Crospovidone 20g

[0045] Povidone 5g

[0046] Magnesium stearate 1.2g

[0047] Process: Mix cetirizine hydrochloride with prescription amount of lactose and microcrystalline cellulose evenly by equal-increasing method, pass through 80-100 mesh sieve, use 5% povidone ethanol as binder, and granulate , dried, granulated, then mixed evenly with crospovidone and magnesium stearate, and compressed into 1000 tablets with a diameter of 6 mm to obtain cetirizine immediate-release tablets;

[0048] (2) Preparation of Pseudoephedrine Sustained-release Tablets

[0049] prescription

[0050] Pseudoephedrine Hydrochloride 120g

[0051] Sodium Alginate 60g

[0052] Glyceryl Behenate 20g

[0053] Magnesium Stearate 2g

[0054] Process: Mix pseudoephedrine hydrochloride, sodium alginate, an...

Embodiment 2

[0058] (1) Preparation of Cetirizine Immediate Release Tablets

[0059] prescription

[0060] Cetirizine Hydrochloride 10g

[0061] Dextrin 100g

[0062] Microcrystalline Cellulose 50g

[0063] Sodium Carboxymethyl Cellulose 30g

[0064] Hypromellose 7g

[0065] Talc powder 1.5g

[0066] Process: Using the equal-increasing method, mix cetirizine hydrochloride with the prescribed amount of dextrin and microcrystalline cellulose evenly, pass through a 80-100 mesh sieve, and use 5% hypromellose ethanol as a binder , granulated, dried, granulated, then mixed evenly with sodium carboxymethyl cellulose and talcum powder, compressed into 1000 tablets with a diameter of 6mm, to obtain cetirizine immediate-release tablets;

[0067] (2) Preparation of Pseudoephedrine Sustained-release Tablets

[0068] Prescription mg / tablet

[0069] Pseudoephedrine Hydrochloride 160g

[0070] Hypromellose 60g

[0071] Ethyl cellulose 20g

[0072] Magnesium Stearate 2g

[0073] Process: Mix pse...

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PUM

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Abstract

The invention relates to a cetirizine pseudoephedrine sustained-release capsule preparation. The interior of the capsule is provided with two tablets with different drug releasing speeds, namely, the cetirizine hydrochloride immediate-release tablet and the pseudoephedrine hydrochloride sustained-release tablet. The preparation has simple preparation process, and the ordinary tablet press machine can complete the process by only one time of tablet pressing; when taken, the cetirizine hydrochloride and the pseudoephedrine hydrochloride can be released simultaneously, so as to better achieve the purpose of combined treatment.

Description

technical field [0001] The invention relates to a new sustained-release capsule preparation, which belongs to the field of pharmaceutical preparations, in particular to a sustained-release capsule preparation composed of cetirizine hydrochloride immediate-release tablets and pseudoephedrine hydrochloride sustained-release tablets. Background technique [0002] Cetirizine, loratadine, and fexofenadine are second-generation antihistamines, which are H1-receptor antagonists and have little sedative effect on the central nervous system. Diseases, such as acute and chronic hives, allergic dermatitis, eczema, allergic rhinitis, etc. At present, it has been widely used in Europe and America, and my country has imported it since the 1990s. Pseudoephedrine is an orally active sympathomimetic drug that has a similar effect to adrenaline. It is mainly used for upper respiratory tract infection diseases such as colds, colds, and allergic rhinitis. It can relieve nasal congestion caused...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/495A61K31/137A61P37/08
Inventor 张明张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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