Compound cetirizine hydrochloride gel

A technology of cetirizine hydrochloride and rizine gel, applied in the field of medicine, can solve the problem of no bactericidal or bacteriostatic effect, etc., and achieve the effects of good affinity, simple and convenient use, and delaying the onset time.

Inactive Publication Date: 2006-04-26
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two patents belong to external preparations, and both use cetirizine hydrochloride as the main ingredient. Cetirizine hydrochloride has strong anti-allergic activity, but has no bactericidal or bacteriostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0018] Specific embodiment one: the compound cetirizine hydrochloride gel of the present embodiment is made of following composition: every 1000g gel contains 100.0g cetirizine hydrochloride, 0.5~2g mupirocin, 5.0~ 10.0g matrix, 60-100ml glycerin or propylene glycol, 5.0-10.0g triethanolamine, add an appropriate amount of phosphoric acid-phosphate buffer solution, adjust the pH value to 6-7, add distilled water to 1000g. The matrix described in this embodiment is Carbomer 940, sodium hydroxymethylcellulose (CMC-Na), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), sodium polypropionate (SDB-L-400), Glycerin gelatin, starch glycerin or sodium alginate, among which carbomer 940 is preferred. The PBS in this embodiment is an abbreviation for phosphoric acid-phosphate buffered saline. PBS varies according to the proportion of ingredients therein, the preparation of the present embodiment: 16gNaCl, 5.65gNaCl 2 HPO 4 12H 2 O, 0.4gKH 2 PO 4, 0.4g KCl, add distilled water to...

specific Embodiment approach 2

[0021] Specific embodiment two: the compound cetirizine hydrochloride gel of the present embodiment is made of following composition: every 1000g gel contains 100.0g cetirizine hydrochloride, 1g mupirocin, 7.5g matrix, 60ml glycerin or propylene glycol, 7.5g triethanolamine, add appropriate amount of PBS, adjust the pH value to 6-7, add distilled water to 1000g.

specific Embodiment approach 3

[0022] Specific embodiment three: the compound cetirizine hydrochloride gel of the present embodiment is made of following composition: every 1000g gel contains 100.0g cetirizine hydrochloride, 0.5g mupirocin, 10.0g matrix , 100ml glycerin or propylene glycol, 10.0g triethanolamine, add appropriate amount of PBS, adjust the pH value to 6-7, add distilled water to 1000g.

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PUM

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Abstract

Disclosed is a cetirizine hydrochloride gelling agent, wherein each 1000g of the gelling agent comprises 100.0g of cetirizine hydrochloride, 0.5-2g of mupirocin, 5.0-10.0g of base, 60-100ml of glycerin propylene glycol, 5.0-10.0g of triethanolamine, right amount of PBS, and balancing distilled water.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antihistamine drug for treating allergic diseases. Background technique [0002] Allergic diseases are common diseases. With the development of modern industry, air pollution is becoming more and more serious, and external harmful substances such as various harmful gases, dust, allergenic microorganisms and allergens directly contact the skin, causing dermatological allergic diseases (especially Allergic skin diseases and urticaria) incidence rate increases year by year. At present, one-third of the world's population suffers from allergic diseases to varying degrees, and with the improvement of modernization, this proportion will increase rapidly. According to the report of the American Academy of Allergy, the incidence of allergic diseases is 20% to 40%, and it has become the sixth largest chronic disease in the United States. In other industrialized countries...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K9/00A61P37/08
Inventor 马满玲
Owner HARBIN MEDICAL UNIVERSITY
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