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Cetirizine hydrochloride tablet and preparation method thereof

A technology of cetirizine hydrochloride and rizine tablets, which can be applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve problems such as corrosion, inability to effectively solve equipment, and difficulty in drug packaging.

Inactive Publication Date: 2013-10-09
广东彼迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it was found in the experiment that due to the good water solubility of cetirizine hydrochloride and the coating material is water soluble, the drug is easy to migrate to the surface of the inclusion compound during the conventional preparation process, so it is almost difficult to wrap the drug completely on the surface of the inclusion compound. inside the material, resulting in the inability to effectively solve the problem of equipment corrosion

Method used

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  • Cetirizine hydrochloride tablet and preparation method thereof
  • Cetirizine hydrochloride tablet and preparation method thereof
  • Cetirizine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation Process:

[0023] (1) Dissolve cetirizine hydrochloride and hydroxypropyl cellulose in 50mL ethanol, add microcrystalline cellulose pellets, stir, dry to remove ethanol, hydroxypropyl cellulose is coated with cetirizine hydrochloride and adheres to the blank pellet surface;

[0024] (2) The drug-loaded pellets obtained in step (1) are uniformly mixed with lactose, sodium carboxymethyl starch and magnesium stearate, and directly compressed into tablets.

Embodiment 2

[0026]

[0027] Preparation Process:

[0028] (1) Dissolve cetirizine hydrochloride and hydroxypropyl cellulose in 120mL ethanol, add lactose pellets, stir, dry to remove ethanol, hydroxypropyl cellulose is coated with cetirizine hydrochloride and adheres to the surface of blank pellets;

[0029] (2) The drug-loaded pellets obtained in step (1) are uniformly mixed with microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate, and directly compressed into tablets.

Embodiment 3

[0031]

[0032] Preparation Process:

[0033] (1) Dissolve cetirizine hydrochloride and hydroxypropyl cellulose in 120mL ethanol, add microcrystalline cellulose pellets, stir, dry to remove ethanol, hydroxypropyl cellulose is coated with cetirizine hydrochloride and adheres to the blank pellet surface;

[0034] (2) The drug-loaded pellets obtained in step (1) are uniformly mixed with pregelatinized starch, crospovidone, and magnesium stearate, and directly compressed into tablets.

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Abstract

The invention discloses a cetirizine hydrochloride tablet and a preparation method thereof. The preparation method of the cetirizine hydrochloride tablet comprises the following steps of: dissolving hydroxy propyl cellulose and cetirizine hydrochloride in alcohol, adding blank pellets and slowly adhering the main drug which is coated by the hydroxy propyl cellulose on the surfaces of the pellets in a slow solvent removal process; and uniformly mixing the drug-carrying pellets and pharmaceutically acceptable auxiliary materials and directly tabletting the mixture to form the cetirizine hydrochloride tablet. According to the preparation method of the cetirizine hydrochloride tablet disclosed by the invention, the cetirizine hydrochloride can be prevented from directly contacting with the external environment, so that a preparation device corrosion problem caused by strong drug acidity during a preparation production process can be avoided.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical solid oral preparations, and in particular relates to a cetirizine hydrochloride tablet and a preparation method thereof. Background technique [0002] Levocetirizine hydrochloride tablet is a selective histamine H1 receptor antagonist preparation. As a new type of antihistamine, it is mainly used to relieve allergic symptoms of allergic diseases. It is clinically used to treat allergic rhinitis, urticaria, Skin and mucous membrane allergic diseases such as angioedema have many advantages such as rapid oral absorption, high receptor selectivity, strong clinical efficacy, small side effects, and good safety. It is the first choice for the treatment of allergic diseases. [0003] At present, there are many dosage forms of cetirizine hydrochloride, but mainly in tablets. However, cetirizine hydrochloride is highly acidic and often corrodes preparation equipment such as tablet machine turntabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K9/20A61K47/38A61P37/08A61P11/02A61P17/00
Inventor 司孝清杨容丽钟燕珍
Owner 广东彼迪药业有限公司
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