Cetirizine hydrochloride orally disintegrating tablets and preparation method thereof

Abstract

The invention discloses cetirizine hydrochloride orally disintegrating tablets, which comprise the main drug of cetirizine hydrochloride and the auxiliary materials of mannitol, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, sodium bicarbonate, citric acid, saccharin sodium, magnesium stearate, talcum powder and essence. The cetirizine hydrochloride orally disintegrating tablets have favorable curative effect on allergic rhinitis, allergen-induced urticaria and pruritus, are convenient to take, can disintegrate rapidly, and provide convenience for the old people, children or patients who suffer from medicine-taking disorders or cannot fetch water conveniently.

Description

Technical field: [0001] The invention relates to an oral pharmaceutical preparation for treating allergic rhinitis, urticaria and skin itching caused by allergens and a preparation method thereof, in particular to a cetirizine hydrochloride which can rapidly disintegrate, release and mask bad taste Orally disintegrating tablet and its preparation method. Background technique: [0002] In the prior art, clinical studies have shown that cetirizine hydrochloride is an antihistamine with high affinity and selectivity to the H1 receptor. Other antihistamines such as terfenadine and astemizole. [0003] At present, although cetirizine hydrochloride has various oral dosage forms, it is not very convenient to use for the elderly and children who have certain difficulties in swallowing, especially for field workers who are inconvenient to get water. For example: In the case of tablets and capsules commonly used as oral preparations, many elderly people and children with poor swallo...

AI Technical Summary

Problems solved by technology

[0003] At present, although cetirizine hydrochloride has various oral dosage forms, it is not very convenient for the elderly and children who have difficulty in swallowing, especially for field workers who are inconvenient to get water

For example: In the case of tablets and capsules commonly used as oral preparations, many elderly people and children with poor swallowing ability are reluctant to take these solid dosage forms, complaining of difficulty swallowing medicine or esophageal obstruction, while chewable tablets are also It is also not suitable for the elderly and children with weak chewing ability

As far as powders or granules are concerned, in addition to their difficulty in swallowing, they are also easy to stay in the mouth, resulting in an unpleasant feeling in the mouth. At the same time, drinking water is required when taking the above-mentioned oral preparations, especially for the elderly and children who need to take a large amount. Drinking enough water can overcome the problem of dysphagia, but drinking too much water will affect the night rest of the elderly and children

Syrups are considered an ideal dosage form for the elderly and children, but for many elderly and infirm patients who are still unable to administer liquid preparations into their own mouths, these dosage forms cannot be considered suitable for the elderly and children due to the difficulties in taking the medication. The most suitable dosage form

In addition, the bitter taste and bad smell of many oral medicines are often unacceptable, causing some patients to refuse treatment in order to avoid taking the medicine, delaying the best time for treatment

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