Leucogen oral disintegration tablet and its preparing method

An orally disintegrating tablet and blood-reducing technology, which is applied in the fields of blood diseases, pill delivery, extracellular fluid diseases, etc., can solve the problems of slow dissolution of oral dosage forms, low bioavailability, and difficulty in swallowing, and achieves no unpleasant taste, High bioavailability, enhanced function

Inactive Publication Date: 2005-01-12
CHENGDU SHENGNUO BIOTEC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of slow dissolution, low bioavailability and difficulty in swallowing of the above-mentioned oral dosage forms, and to provide a Lixuesheng orally disintegrating tablet capable of rapid disintegration, release and masking of bad taste and its preparation method, so as to achieve The purpose of improving the ease of use and convenience of Lixuesheng oral preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: prescription test

[0034] Lexogen 10.0g

[0035] Lactose 34.0g

[0036] Mannitol 20.0g

[0037] Microcrystalline Cellulose 26.0g

[0038] Low-substituted hydroxypropyl cellulose 2.5g

[0039] Cross-linked polyvinylpyrrolidone 2.5g

[0040] Magnesium Stearate 1.0g

[0041] Sodium bicarbonate 1.0g

[0042] Citric acid 1.0g

[0043] Aspartame 1.0g

[0044] Peppermint essence 1.0g

[0045] A total of 1000 tablets were produced

[0046] Preparation method: Take the above-mentioned components, pulverize them, pass through a 100-mesh sieve, weigh each component according to the above-mentioned prescription amount, mix them uniformly, send the powder into a conventional tablet machine, and perform tablet compression to obtain a tablet with a weight of 100 mg. Xuesheng orally disintegrating tablets.

[0047] Test result: Tablet hardness: 15~40N

[0048] Disintegration time limit: 20-50 seconds

[0049] Taste: No gritty and unpleasant taste, ...

Embodiment 2

[0050] Embodiment 2: prescription test

[0051] Lexogen 20.0g

[0052] Mannitol 60.0g

[0053] Sorbitol 33.0g

[0054] Microcrystalline Cellulose 47.0g

[0055] Low-substituted hydroxypropyl cellulose 10.0g

[0056] Cross-linked polyvinylpyrrolidone 20.0g

[0057] Magnesium Stearate 2.0g

[0058] Sodium bicarbonate 2.0g

[0059] Citric acid 2.0g

[0060] Sucralose 2.0g

[0061]Peppermint essence 2.0g

[0062] A total of 1000 tablets were produced

[0063] Preparation:

[0064] Step 1: Grind the leucogen and various auxiliary materials separately, pass through a 100-mesh sieve, and store them separately for later use;

[0065] Step 2: Weigh Lexusan, mannitol, and 75% of the prescribed amount of microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and cross-linked polyvinylpyrrolidone according to the prescribed amount, and fully mix them;

[0066] Step 3: Add an appropriate amount of absolute ethanol to the above-mentioned uniformly mixed components,...

Embodiment 3

[0072] Embodiment 3: prescription test

[0073] Lexogen 10.0g

[0074] Mannitol 70.0g

[0075] Sorbitol 33.0g

[0076] Microcrystalline Cellulose 47.0g

[0077] Low-substituted hydroxypropyl cellulose 10.0g

[0078] Cross-linked polyvinylpyrrolidone 20.0g

[0079] Magnesium Stearate 2.0g

[0080] Sodium bicarbonate 2.0g

[0081] Citric acid 2.0g

[0082] Sucralose 2.0g

[0083] Peppermint essence 2.0g

[0084] A total of 1000 tablets were produced

[0085] Preparation method: Weigh each component according to the above prescription amount, mix them evenly, pass through a 100-mesh sieve, send the powder into a conventional tablet press, and perform tablet compression to obtain Lixuesheng orally disintegrating tablets with a tablet weight of 200 mg.

[0086] Test result: Tablet hardness: 15~40N

[0087] Disintegration time limit: 20-50 seconds

[0088] Taste: No gritty and unpleasant taste, no foreign body feeling.

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Abstract

An oral disintegrating tablet of leucoson for improving hematopoietic function is prepared from leucoson, filler, disintegrant, effervescent agent, lubricant and flavouring through pulverizing, proportional mixing and tablet.

Description

Technical field: [0001] The present invention relates to a Lixuesheng orally disintegrating tablet that can rapidly disintegrate and release drugs in the oral cavity, has the function of enhancing the hematopoietic system, and is used for the treatment of leukopenia and aplastic anemia. The present invention also relates to the preparation of the preparation method. Background technique: [0002] The chemical name of Lexusan is 2-(α-phenyl-α-ethoxycarbonyl-methyl)thiazolidine-4-carboxylic acid, which is a typical thiazole carboxylic acid anti-cancer whitening drug, which has the effect on white blood cells. It can promote proliferation and can be widely used in the prevention and treatment of leukopenia caused by radiation exposure and chemical drugs; treatment of thrombocytopenia; aplastic anemia, etc. Especially in combination with radiotherapy or anticancer drugs, it has superior clinical effect and is welcomed by the majority of patients and medical staff. [0003] At ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/426A61P7/00A61P35/00
Inventor 谢期林
Owner CHENGDU SHENGNUO BIOTEC CO LTD
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